| Brand Score Ltd | Information & communication | 2019 |
| Branded Communications Ltd | Professional & scientific | 2011 |
| Brandling Ventures Ltd | Financial services | 2022 |
| Brandon Access Ltd | Professional & scientific | 2025 |
| Breathe & Protect LLP | | 2020 |
| Brettsinclaire Limited | Professional & scientific | 2019 |
| Brightblue Studio Ltd | Hospitality | 2004 |
| Brighter Compliance Limited | Professional & scientific | 2021 |
| Broadband Satellite Services Limited | Information & communication | 2012 |
| Broadway ST. Ltd. | Hospitality | 2018 |
| Brones Ventures Ltd | Financial services | 2020 |
| Brood Play Cafe Ltd | Hospitality | 2024 |
| Brothers of Nahm Trading Ltd | Hospitality | 2025 |
| Brown Holliday & Clements Limited | Professional & scientific | 2025 |
| Brown Sugar Consultancy Ltd | Hospitality | 2010 |
| Brtechnical Solutions Limited | Professional & scientific | 2015 |
| BRZ Fleet Management Ltd | Professional & scientific | 2021 |
| BSM Plumbing Ltd | Construction | 2020 |
| Bts-Alb Limited | Wholesale & retail | 2024 |
| Buglass Investment Group Limited | Real estate | 2024 |
| Build North Limited | Construction | 2024 |
| Burns & Turner Ltd | Administrative & support | 2017 |
| Burns Waste Management Ltd | Water & waste | 2024 |
| Burton Collingwood Limited | Real estate | 2011 |
| Butler-Curnow Building Surveyors LLP | | 2020 |
| Buzztastic Limited | Professional & scientific | 2014 |
| BY Your Side NE Ltd | Administrative & support | 2022 |
| BYD Kitchen & Bathrooms Limited | Construction | 2024 |
| BYD Sofa, Beds and Mattress Limited | Wholesale & retail | 2023 |
| Bymadielin Ltd | Other services | 2025 |
| C a Servicing Ltd | Manufacturing | 2026 |
| C and H Lifting Ltd | Construction | 2026 |
| C Community Care Ltd | Health & social care | 2025 |
| C M Accountants Limited | Professional & scientific | 2010 |
| C N C Installations Ltd | Construction | 2019 |
| C W Gaming Limited | Professional & scientific | 2017 |
| C&D Quality Homes Ltd | Construction | 2020 |
| C&E Consulting Ltd | Professional & scientific | 2020 |
| C&G Care Consultancy LLP | | 2024 |
| C&J Shipping Limited | Wholesale & retail | 2024 |
| C&P Estates Limited | Real estate | 2018 |
| C3DT Ltd | Professional & scientific | 2015 |
| Caaba Holdings Ltd | Arts & recreation | 2026 |
| Cabin Solutions Limited | Hospitality | 2020 |
| Cafe Floriana Ltd | Hospitality | 2023 |
| Cafe LA Verne Limited | Hospitality | 2019 |
| Cafe Sambuca Blyth Limited | Hospitality | 2024 |
| Calathea Freddie Limited | Professional & scientific | 2024 |
| Calum Hall Hair Design Ltd | Other services | 2022 |
| Campaign Studio Limited | Other services | 2018 |
| CAMPERS4ALL Limited | Wholesale & retail | 2018 |
| Canatec Ltd | Manufacturing | 2015 |
| Candoprop Ltd | Real estate | 2023 |
| Cania Constructions Limited | Construction | 2025 |
| Canine Camp Limited | Other services | 2016 |
| Canny Coffees Limited | Hospitality | 2022 |
| Canny Local Vending Co Ltd | Wholesale & retail | 2023 |
| Canny Sound Ltd | Information & communication | 2023 |
| Capital Investing Solutions Ltd | Professional & scientific | 2023 |
| Captain Robinson Mews Limited | Households | 2013 |
| Car Tech (North Shields) Limited | Wholesale & retail | 2018 |
| Caravan Storage Ltd | Other services | 2011 |
| Carbongrind Ltd | Wholesale & retail | 2025 |
| Careerchatuk Limited | Information & communication | 2022 |
| Caremap Ltd | Professional & scientific | 2025 |
| Carespine Limited | Health & social care | 2016 |
| Cargo Creative Ltd | Administrative & support | 2009 |
| Carl Hedley Roofing & Building Ltd | Construction | 2023 |
| Carlton Club Whitley Bay Ltd | Hospitality | 2019 |
| Carnook Ltd | Wholesale & retail | 2025 |
| Carr Financial Planning Ltd | Financial services | 2023 |
| Carrera Computers Limited | Information & communication | 2010 |
| Cartec @ Vroom Limited | Wholesale & retail | 2009 |
| Cartec Motor Company Limited | Wholesale & retail | 2014 |
| Carter Drone Surveyors Ltd | Professional & scientific | 2022 |
| Casa Inganni Ltd | Real estate | 2026 |
| Casa Lory Ltd | Financial services | 2025 |
| Casc Developments Ltd | Real estate | 2010 |
| Cassia Gosforth Ltd | Hospitality | 2025 |
| Cassia Silverlink Ltd | Hospitality | 2020 |
| Castle Scaffold (Northern) Limited | Administrative & support | 1995 |
| Cat Propurrties Limited | Real estate | 2023 |
| Cath Brown Consultancy Ltd | Professional & scientific | 2017 |
| Cbailey Computing Limited | Information & communication | 2014 |
| CBL Data Recovery (Newcastle) Limited | Information & communication | 2014 |
| CD NE Scaffolding Ltd | Construction | 2025 |
| CDM Access Limited | Transport & logistics | 2024 |
| CE Domestic Cleaning Services Ltd | Administrative & support | 2022 |
| Celebration Nation Limited | Arts & recreation | 2005 |
| Celestial Roofing Ltd | Construction | 2016 |
| Central Motors North East Ltd | Wholesale & retail | 2010 |
| Central Supplies (Brierley Hill) Ltd | Wholesale & retail | 1993 |
| Ceramic Panda Ltd | Wholesale & retail | 2024 |
| CF Access Ltd | Manufacturing | 2022 |
| CG Brokerage Services Ltd | Wholesale & retail | 2020 |
| Chain Reaction NCL Ltd | Hospitality | 2022 |
| Chambers Property Development Limited | Real estate | 2024 |
| Charleston Events Ltd | Arts & recreation | 2025 |
| Chelle Limited | Manufacturing | 2004 |
| Cherish Care Services Ltd | Health & social care | 2026 |