| Tynemouth Amateur Swimming Club | Arts & recreation | 2000 |
| Tynemouth Brewing Company Limited | Manufacturing | 2020 |
| Tynemouth Coast Limited | Hospitality | 2020 |
| Tynemouth Coffee Company Ltd | Wholesale & retail | 2011 |
| Tynemouth Cricket Club Limited | Arts & recreation | 2016 |
| Tynemouth Cricket Trading Company Limited | Arts & recreation | 2016 |
| Tynemouth Decorators Limited | Construction | 2010 |
| Tynemouth Hand Car Wash Ltd | Administrative & support | 2017 |
| Tynemouth Motor Company Select Limited | Wholesale & retail | 1999 |
| Tynemouth Motor Company Specialist Cars Limited | Wholesale & retail | 1999 |
| Tynemouth Nursery Group Limited | Education | 1999 |
| Tynemouth Precision Paving Ltd | Construction | 2024 |
| Tynemouth Priory Theatre | Arts & recreation | 1997 |
| Tynemouth Residential Limited | Real estate | 2013 |
| Tynemouth Sailing Club | Arts & recreation | 2018 |
| Tynemouth Squash Rackets Club Limited | Arts & recreation | 1977 |
| Tynemouth SUP Boarder Ltd | Wholesale & retail | 2022 |
| Tynemouth Trade Limited | Wholesale & retail | 2021 |
| Tynemouth Traders Limited | Wholesale & retail | 2022 |
| Tyneside Components Ltd | Wholesale & retail | 2017 |
| Tyneside Fire Sprinklers Ltd | Professional & scientific | 2022 |
| Tyneside Marketing Ltd | Professional & scientific | 2023 |
| Tyneside Property Holdings Ltd | Real estate | 2007 |
| Tyneside Ventures Ltd | Financial services | 2023 |
| Tynesidedelivery Ltd | Transport & logistics | 2025 |
| Tynesidespirits&Beverages Ltd | Wholesale & retail | 2025 |
| Tynetech Electrical Services Ltd | Construction | 2015 |
| Tyneview Road Construction Limited | Construction | 1998 |
| Typex (U.K) Limited | Information & communication | 1986 |
| Tyre Stop (North East) Limited | Wholesale & retail | 2012 |
| Tyrp Ltd | Arts & recreation | 2019 |
| U CAN TAN Ltd | Other services | 2023 |
| U.Well Ltd | Wholesale & retail | 2016 |
| Uber Limited | Real estate | 2004 |
| Ubique Rugby Ltd | Wholesale & retail | 2024 |
| UK Complement Research and Education Limited | Education | 2024 |
| UK Motorhome Hire Company Limited | Administrative & support | 2009 |
| Uk/Ldn Goods Ltd | Wholesale & retail | 2021 |
| Ultimate Competitions Ltd | Arts & recreation | 2025 |
| Ultracool Air Conditioning NE Ltd | Construction | 2022 |
| Uncommon Souls Ltd | Hospitality | 2023 |
| Undefined Ltd. | Arts & recreation | 2014 |
| Underplay Limited | Administrative & support | 2001 |
| Undiscovered Destinations Limited | Administrative & support | 2004 |
| Union Quay Holding Company Ltd | Financial services | 2024 |
| Union Quay Ltd | Health & social care | 2024 |
| Uniprise Technologies Ltd | Information & communication | 2026 |
| Unique Theatre Limited | Arts & recreation | 2026 |
| Unknown Projects Events Limited | Other services | 2025 |
| Unknown Projects Ltd | Hospitality | 2023 |
| Urban Design Works Limited | Professional & scientific | 2026 |
| Uroprep Limited | Education | 2025 |
| Usher Family Law Limited | Professional & scientific | 2017 |
| V Finance Inc. Ltd | Wholesale & retail | 2025 |
| V.P.M. One Trading Limited | Real estate | 2022 |
| VAA Engineering Ltd | Professional & scientific | 2023 |
| Validus Investments Limited | Real estate | 2015 |
| Valkyrie Ventures Ltd | Professional & scientific | 2024 |
| Valley Gardens Childrens Club Limited | Education | 2012 |
| Valour Logistics Ltd | Transport & logistics | 2025 |
| Varcoemedia Ltd | Professional & scientific | 2020 |
| Vaughan Access Limited | Administrative & support | 2026 |
| Vega Crypto Strategies Ltd | Information & communication | 2025 |
| Vellossa Ltd | Professional & scientific | 2015 |
| Velvétis Clinic Ltd | Other services | 2024 |
| Venderoo Ltd | Construction | 2020 |
| Venture Zero North East Community Interest Company | Professional & scientific | 2021 |
| Ventus Energy Holdings Limited | Financial services | 2020 |
| Ventus Energy Limited | Construction | 2003 |
| Venue 29 Ltd | Arts & recreation | 2024 |
| Viba Homes Limited | Real estate | 2022 |
| Vibrant Hearing Ltd | Health & social care | 2022 |
| Vibrant Hearing Services Ltd | Health & social care | 2014 |
| Vibrissa Pet Services Ltd | Other services | 2026 |
| Victoria Tessa Ltd | Arts & recreation | 2014 |
| Vida Creative Ltd | Information & communication | 2016 |
| Video Enhanced Observation Ltd | Education | 2015 |
| Video Wall Hire Ltd | Information & communication | 2018 |
| Vineyard 72 Cocktails Limited | Hospitality | 2024 |
| Vineyard 72 Events Limited | Hospitality | 2024 |
| Vinyl Systems Research Ltd | Manufacturing | 2022 |
| Viperio Ltd | Arts & recreation | 2017 |
| Visibly Tech Limited | Information & communication | 2021 |
| Vision Accountants Ltd | Professional & scientific | 2020 |
| Vistel Property Holdings Ltd | Real estate | 2023 |
| Vivus Care & Support Ltd | Construction | 2022 |
| VLM Therapy Limited | Health & social care | 2024 |
| VM Consultancy Limited | Professional & scientific | 2015 |
| Void of Course Ltd | Information & communication | 2023 |
| Vorsdatter Limited | Information & communication | 2017 |
| Vyve Health CIC | Health & social care | 2025 |
| W @ H Safety Solutions Ltd | Professional & scientific | 2020 |
| W Eves & Co (Service Stations) Limited | Real estate | 2000 |
| W Eves Holdings AB Ltd | Financial services | 2026 |
| W Eves Holdings AD Ltd | Financial services | 2026 |
| W Eves Holdings KW Ltd | Financial services | 2026 |
| Wairo Ltd | Professional & scientific | 2025 |
| Wakkamu ACT Ltd | Health & social care | 2022 |
| Waldridge Developments Limited | Construction | 1981 |
| Walker Maintenance Limited | Administrative & support | 2015 |