| Qualitrans Consulting Limited | Transport & logistics | 2023 |
| Quality Personal Development Training Ltd | Arts & recreation | 2007 |
| R. Kendall Holdings Limited | Professional & scientific | 2025 |
| R. Kendall Investments Limited | Professional & scientific | 2025 |
| R. Kendall Limited | Agriculture & fishing | 2016 |
| R. Spivey and SON Limited | Water & waste | 1980 |
| Rain Media Limited | Professional & scientific | 2023 |
| Rainham Insulation Services Limited | Construction | 2005 |
| Rashsash Limited | Professional & scientific | 2023 |
| RC Plant Services Limited | Administrative & support | 2005 |
| RCI Property Solutions Ltd | Real estate | 2023 |
| Red Leisure Limited | Hospitality | 2019 |
| Regisbourne Limited | Construction | 1977 |
| Reldene Estates Limited | Construction | 1943 |
| Reldene Investments Limited | Construction | 1962 |
| Richard Swinburne TC Ltd | Administrative & support | 2022 |
| River Business Services Limited | Financial services | 2022 |
| River Energy & Renewables Limited | Other services | 2022 |
| River Equity Limited | Financial services | 2025 |
| River Lodge Consultants Limited | Professional & scientific | 2021 |
| River Telecommunications Limited | Administrative & support | 2013 |
| Riverline Electrical Contractors Limited | Construction | 2007 |
| Riverview Developers UK Ltd | Construction | 2025 |
| Riverview Properties Hull Ltd | Real estate | 2024 |
| RMT (East Riding) Limited | Real estate | 1982 |
| Robert Avery Residential Limited | Real estate | 1995 |
| Rowland Ventures Limited | Hospitality | 2013 |
| RS Specialist Cars Limited | Wholesale & retail | 1996 |
| Rubitec Engineering Limited | Manufacturing | 2008 |
| Rudstone Residential Ltd | Real estate | 2000 |
| RWD Academy Limited | Other services | 2022 |
| Rybell Limited | Financial services | 2020 |
| S F Controls Limited | Information & communication | 2014 |
| S J Thompson Electrical Ltd | Construction | 2017 |
| S T Carter Limited | Information & communication | 2016 |
| S.A.Q. Leisure Ltd | Extraterritorial | 2016 |
| SAC Developments (Hull) Limited | Real estate | 2025 |
| SAL AGC Limited | Arts & recreation | 2012 |
| SAM Co (Yorkshire) Ltd | Financial services | 2024 |
| Samantha Hillerby Limited | Administrative & support | 2012 |
| Samantha Towle Writes Limited | Arts & recreation | 2012 |
| SAN SAN MS Limited | Real estate | 2025 |
| Sands UK Projects Ltd | Real estate | 2026 |
| Sarcs Symposium Ltd | Extraterritorial | 2023 |
| SAS Lining Services Limited | Other services | 2004 |
| Savannah Dreams C.I.C. | Real estate | 2022 |
| Scarytree Limited | Information & communication | 2006 |
| Schmaltz Brew Co. Limited | Manufacturing | 2025 |
| Science Bible Ltd | Information & communication | 2026 |
| Scope Technologies UK Limited | Information & communication | 2022 |
| SD Training Services Limited | Education | 2025 |
| Seaport Logistics Services Limited | Transport & logistics | 2002 |
| Second on the Left Ltd | Professional & scientific | 2015 |
| Sekhri & Associates Ltd | Health & social care | 2022 |
| Sema Facilities Management Limited | Extraterritorial | 2009 |
| Sercom Oils UK Limited | Professional & scientific | 2013 |
| Servicare Ltd | Other services | 2024 |
| Seven Seas Healthcare Limited | Manufacturing | 2016 |
| Shard Stone Limited | Professional & scientific | 2011 |
| Sharrock Building Design Limited | Professional & scientific | 2010 |
| Shiva Manjula Limited | Health & social care | 2021 |
| Shop Tea Time Ltd | Wholesale & retail | 2026 |
| Shree Properties and Rentals Ltd | Real estate | 2022 |
| Shri Vinayak Ltd | Real estate | 2026 |
| Simon Cook Holdings Limited | Real estate | 2016 |
| Sioux Property Limited | Real estate | 2020 |
| Sips Panel Technologies (UK) Limited | Manufacturing | 2019 |
| Skyy Logistics Ltd | Transport & logistics | 2025 |
| Smile Energy Limited | Households | 2025 |
| Smile Property Ltd | Real estate | 2025 |
| SMJ Electrical Services Limited | Construction | 2009 |
| Smooth Swinger Golf Ltd | Manufacturing | 2024 |
| Smsg Private Limited | Health & social care | 2019 |
| SOS Stationery Office Supplies Limited | Wholesale & retail | 2007 |
| Soto Furniture Ltd | Wholesale & retail | 2021 |
| Southgate Estates & Rentals Limited | Real estate | 2024 |
| SP Transport (Lincs) Ltd | Transport & logistics | 2020 |
| Sparc Sports Limited | Arts & recreation | 2025 |
| Sparkleuk Ltd | Administrative & support | 2026 |
| Ss&S Properties 2023 Limited | Real estate | 2023 |
| ST. James Court Management (Hull) Limited | Real estate | 1985 |
| Starmed Consult Ltd | Professional & scientific | 2016 |
| Starmed Properties Ltd | Real estate | 2021 |
| Start 2 Finish Building UK Ltd | Construction | 2020 |
| Station Investments Limited | Construction | 2014 |
| Stay Static Limited | Hospitality | 2016 |
| Stoneferry Estates 2 Limited | Construction | 2024 |
| Stoneferry Estates Limited | Real estate | 2024 |
| Stoneferry Properties Ltd | Real estate | 2021 |
| Street PR UK Limited | Administrative & support | 2012 |
| Summit Vans Limited | Administrative & support | 2022 |
| Sumrise Ltd | Information & communication | 2022 |
| Sunset Partners Limited | Administrative & support | 2021 |
| Sustainable Ferriby Community Interest Company | Professional & scientific | 2025 |
| SVS Medical Services Limited | Health & social care | 2013 |
| Swanedge Limited | Manufacturing | 2024 |
| Swanland Aesthetics Ltd | Other services | 2020 |
| Swanland Education Africa Trust | Administrative & support | 2010 |
| Swanland Village OUT of School Club Limited | Other services | 2022 |
| Swanland Vintage Clothing Company Limited | Wholesale & retail | 2025 |