| Prize Solutions Limited | Administrative & support | 2005 |
| Proactive Mental Health Ltd | Information & communication | 2025 |
| Process Engineering Facilities Ltd | Professional & scientific | 2017 |
| Protech Direct Limited | Extraterritorial | 2003 |
| Proud Zebra Limited | Real estate | 2020 |
| PST Capital Investments Ltd | Financial services | 2015 |
| Psyphr Limited | Information & communication | 2017 |
| Pulse Accountants & Tax Advisers Limited | Professional & scientific | 2020 |
| Pulse Technology Advisory Limited | Information & communication | 2025 |
| Purdoms Development Ltd | Construction | 2015 |
| Purdoms Sporting Ltd | Other services | 2017 |
| Purdoms Training Ltd | Other services | 2015 |
| Pure Platinum Steel Buildings Ltd | Construction | 2018 |
| PWS Distributors Limited | Wholesale & retail | 1988 |
| QDS Holdings Ltd | Financial services | 2019 |
| Quality Hospital Solutions Limited | Professional & scientific | 2007 |
| Quay Diving Services Ltd | Administrative & support | 2011 |
| Quayle Earthworks Limited | Construction | 2022 |
| R.S Global Group Ltd | Transport & logistics | 2026 |
| Radac UK Limited | Financial services | 2024 |
| Radiographic Accessories Limited | Manufacturing | 1994 |
| Raisco Limited | Manufacturing | 2007 |
| Raisway Limited | Extraterritorial | 2023 |
| Ramsey's Campervans Ltd | Administrative & support | 2018 |
| Ramsey's Limited | Wholesale & retail | 1993 |
| Raoeo Ltd | Financial services | 2008 |
| Rareprime Limited | Professional & scientific | 2008 |
| Ravenstonedale Limited | Real estate | 1983 |
| RCC NDT Limited | Construction | 2024 |
| RDJ Inspection Services Ltd | Professional & scientific | 2013 |
| Recoverycorp (NE) Ltd | Wholesale & retail | 2022 |
| Red Square Furniture Limited | Wholesale & retail | 2022 |
| Redline Prestige Cars Ltd | Wholesale & retail | 2015 |
| Redworth Caledonian Associates Limited | Financial services | 2005 |
| Redworth Estate Properties Ltd | Real estate | 2020 |
| Rentagenie Ltd | Real estate | 2022 |
| Restore Group Limited | Manufacturing | 2014 |
| REV Care Limited | Construction | 2015 |
| RH Engineering and Surveying Limited | Professional & scientific | 2016 |
| Rifleworks Limited | Wholesale & retail | 2011 |
| Riversmount Services Limited | Real estate | 2017 |
| RJD Express Ltd | Transport & logistics | 2025 |
| RJS Holdings (Northern) Limited | Financial services | 2024 |
| RJS Laser Limited | Manufacturing | 2004 |
| RK Cladding Limited | Construction | 2017 |
| Rkayxbl Ltd | Arts & recreation | 2026 |
| RMB Transport Services (NE) Ltd | Transport & logistics | 2017 |
| Robert Quinn Construction Ltd | Construction | 2018 |
| Robinson Engineering Limited | Manufacturing | 2000 |
| Robinson Holding Group Limited | Financial services | 2025 |
| Robinson-Raine Joinery Limited | Construction | 2019 |
| Robinsons Ground & Garden Services Ltd | Administrative & support | 2025 |
| Robotrol Limited | Manufacturing | 2006 |
| ROC Family Time Limited | Health & social care | 2001 |
| ROC Group Limited | Health & social care | 2005 |
| ROC Home Limited | Health & social care | 2018 |
| ROC Housing Management Limited | Households | 2008 |
| ROC Solid | Administrative & support | 2007 |
| ROC Support Limited | Health & social care | 2009 |
| ROC Transitions Limited | Health & social care | 2023 |
| Rocket Healthcare Limited | Information & communication | 2026 |
| Rocket House Investments Limited | Real estate | 2017 |
| Rocket Recruitment Ltd | Information & communication | 2020 |
| Rockline Buildings (International) Limited | Wholesale & retail | 1978 |
| Rodgers Plant & Equipment Limited | Construction | 2017 |
| Rogsen Ltd | Administrative & support | 2019 |
| Roker 1898 Ltd | Professional & scientific | 2023 |
| Roman Limited | Manufacturing | 1987 |
| Rooftrust Limited | Construction | 2019 |
| Root Investors Ltd | Real estate | 2025 |
| Rope Moor Limited | Financial services | 1996 |
| Rpmr Healthcare Limited | Real estate | 2017 |
| RSG Joinery Limited | Construction | 2019 |
| Rtbey Orerl Ltd | Wholesale & retail | 2025 |
| Ruff 'N' Tumble Adventure World Limited | Arts & recreation | 2003 |
| Runnymede Limited | Real estate | 2022 |
| RW Boxing Ltd | Education | 2026 |
| Ryder Geotechnical Limited | Professional & scientific | 2016 |
| S & T PUB Company Limited | Hospitality | 2024 |
| S a F Transport Ltd | Transport & logistics | 2014 |
| S-Dam Trans Ltd | Other services | 2014 |
| S-Worx MEP Ltd | Construction | 2024 |
| S.C.H. Site Services Ltd | Manufacturing | 2005 |
| S.Melvin Tiling Contractors Ltd | Construction | 2014 |
| S.S.H Architectural Installations Ltd | Construction | 2024 |
| S.W. Durham Training Limited | Education | 1967 |
| Sabre Rail Holdings Limited | Financial services | 2025 |
| Sabre Rail Services Limited | Manufacturing | 1987 |
| Safewear (Teesside) Ltd | Wholesale & retail | 1958 |
| Sara & Simon Limited | Professional & scientific | 2008 |
| Sash Hardware (Northern) Limited | Wholesale & retail | 2012 |
| Sauki Auto Services and Recovery Ltd | Wholesale & retail | 2026 |
| Save OUR Reds CIC | Extraterritorial | 2026 |
| Savvy FS Ltd | Financial services | 2025 |
| SB Holdings (Teesside) Limited | Financial services | 2024 |
| SBL Executive Management Services Ltd | Professional & scientific | 2023 |
| Scafell Organics Limited | Manufacturing | 2003 |
| Scene Agency Limited | Administrative & support | 2026 |
| Scpr Ltd | Hospitality | 2024 |
| Seatsmart Limited | Information & communication | 2026 |