| Prospect Developments Limited | Administrative & support | 1984 |
| Prospectbase B2B Holdings Limited | Financial services | 2024 |
| Prospectbase UK Limited | Administrative & support | 2024 |
| Protego Air Conditioning and Ventilation Systems Limited | Construction | 2021 |
| Protego Fire & Security Limited | Administrative & support | 2014 |
| Proviro (UK) Ltd | Manufacturing | 2004 |
| Prowash Southwest Ltd | Administrative & support | 2025 |
| Proweld UK Limited | Wholesale & retail | 1991 |
| Proworx South West Limited | Construction | 2023 |
| Psychotherapy & Counselling Exeter Ltd | Real estate | 2021 |
| PT Land Devon Limited | Real estate | 2018 |
| PTR Lettings Ltd | Transport & logistics | 2004 |
| PUB & Nosebag Ltd. | Hospitality | 2018 |
| Pugco Ltd | Wholesale & retail | 2024 |
| Pullan Medical Ltd | Health & social care | 2020 |
| Puma Berry Ltd | Information & communication | 2015 |
| Pump Street Management Limited | Real estate | 2012 |
| Pureherbal Limited | Agriculture & fishing | 2024 |
| Puretrail UK Ltd | Arts & recreation | 2015 |
| Putsborough Sands Limited | Hospitality | 2005 |
| PV Georgiev Ltd | Health & social care | 2012 |
| PWD Interior Solutions Ltd | Construction | 2010 |
| PWS Accounting Ltd | Professional & scientific | 2018 |
| PYE END Developments Limited | Real estate | 1964 |
| Q-Ball Media Limited | Professional & scientific | 2006 |
| Q10 Limited | Professional & scientific | 2013 |
| QA Leads Limited | Administrative & support | 2023 |
| QFT Limited | Extraterritorial | 2013 |
| QG1FAMBR Ltd | Transport & logistics | 2023 |
| QG2FAMBR Ltd | Transport & logistics | 2023 |
| Quality Construction (South West) Limited | Construction | 2005 |
| Quality Hand Car Wash (SW) Ltd | Administrative & support | 2014 |
| Quantex Construction Consultancy (SW) Limited | Professional & scientific | 2026 |
| Quantitative Transformation AI Ltd | Information & communication | 2026 |
| Quantum Security Defence Limited | Information & communication | 2024 |
| Quasar Microwave Technology Ltd | Manufacturing | 2014 |
| Quasar Property Holdings Limited | Financial services | 2004 |
| Quay Confectionery Ltd | Wholesale & retail | 2021 |
| Quay Comps Ltd | Wholesale & retail | 2026 |
| Quay Developments Luxulyan Limited | Construction | 2009 |
| Quay Property Holdings South West Ltd | Financial services | 2025 |
| Quay Scaffolding Limited | Construction | 2012 |
| Quay Waste Limited | Water & waste | 2002 |
| Qube Accountants Limited | Professional & scientific | 2022 |
| Queenstone Estates Ltd | Real estate | 2026 |
| Quel BON Pays Limited | Professional & scientific | 2023 |
| Questo Eperlei Ltd | Real estate | 2009 |
| Quickbuild (U K) Limited | Professional & scientific | 2005 |
| Quickstore (UK) Ltd | Construction | 2019 |
| QUODITCH21 Ltd | Agriculture & fishing | 2015 |
| Quote and CUT Ltd | Information & communication | 2026 |
| R & G Installations (SW) Ltd | Construction | 2022 |
| R & L G Holdings Limited | Real estate | 2024 |
| R & S Distributors Limited | Wholesale & retail | 2008 |
| R a Decorators Ltd | Construction | 2023 |
| R J Everitt Coins Ltd | Professional & scientific | 2010 |
| R J Pascoe Limited | Construction | 2003 |
| R Jefferies Ltd | Wholesale & retail | 2024 |
| R S Inspection Limited | Transport & logistics | 2013 |
| R S Putman Limited | Transport & logistics | 2007 |
| R. Northcott Roofing Limited | Construction | 2016 |
| R.B. Leisure Limited | Construction | 2004 |
| R.C.G.M Limited | Wholesale & retail | 2013 |
| R.D. Johns Limited | Wholesale & retail | 1986 |
| R.F. Gliddon & Company (Plymouth) Limited | Other services | 1982 |
| R.J. Smith (Newton Abbot) Limited | Real estate | 1985 |
| R50 Marketing Limited | Wholesale & retail | 2022 |
| RAC Medical Limited | Health & social care | 2022 |
| Rachael Baker Limited | Other services | 2005 |
| Radford Builders Limited | Construction | 2016 |
| Radical Escapes Limited | Administrative & support | 1999 |
| Rafe Spall Limited | Arts & recreation | 2014 |
| Rafikis South West Limited | Hospitality | 2024 |
| Raging Woody Ltd | Construction | 2024 |
| Raithai Ltd | Real estate | 2025 |
| Ralhar Ltd | Transport & logistics | 2023 |
| Ralphmali Limited | Hospitality | 2021 |
| Randall Simmonds LLP | | 2009 |
| Rapid Response 24/7 Plumbing & Heating Ltd | Construction | 2025 |
| Ravem Group Ltd | Construction | 2021 |
| Raymond White Limited | Information & communication | 2016 |
| RB Projx Limited | Transport & logistics | 2015 |
| RB Tech (SW) Limited | Information & communication | 2017 |
| Rbvb Projx Limited | Transport & logistics | 2016 |
| Rbvblb Projx Limited | Transport & logistics | 2021 |
| Rbvblbyb Projx Limited | Transport & logistics | 2021 |
| RBVBLBYBHB1012 LLP | | 2012 |
| Rbvbyb Projx Limited | Transport & logistics | 2021 |
| RBW Homecare Limited | Health & social care | 2024 |
| RC 01 LLP | | 2026 |
| RC Services (SW) Limited | Financial services | 2020 |
| RC Stoneworks Ltd | Construction | 2022 |
| RCS Securities Limited | Financial services | 2004 |
| RD Trees & Landscapes Limited | Administrative & support | 2018 |
| Re-Tyred Ltd | Wholesale & retail | 2024 |
| Re-Zip Packaging Ltd | Transport & logistics | 2022 |
| Re:Fuel Southwest Ltd | Hospitality | 2019 |
| Realcoachrory Limited | Arts & recreation | 2019 |
| Really Awesome Technology Ltd | Education | 2019 |
| Really Helpful Club LLP | | 2013 |