| Elite Socials Ltd | Professional & scientific | 2021 |
| Elizabeth Mccormick Consulting Limited | Professional & scientific | 2018 |
| Elko Wellness Limited | Health & social care | 2026 |
| Elle Hair Ltd | Other services | 2015 |
| Ellickson Engineering Northern Ireland Limited | Professional & scientific | 2021 |
| Ellisholding Developments Limited | Real estate | 2019 |
| Ellisholding Properties Ltd | Real estate | 2023 |
| ELM Surgical Services Ltd | Health & social care | 2024 |
| Elmhall Developments Ltd | Construction | 2023 |
| Elmore Safety Services Ltd | Professional & scientific | 2025 |
| Elsieotter & Co Ltd | Professional & scientific | 2024 |
| Elta Utilities Limited | Construction | 2019 |
| Eltree Limited | Real estate | 1994 |
| Elvis Ents Limited | Administrative & support | 2026 |
| EM & SM Construction Ltd | Construction | 2011 |
| Emain Macha Limited | Financial services | 2021 |
| EMC Advisory Ltd | Information & communication | 2026 |
| EMD Consulting (IRE) Ltd | Construction | 2021 |
| Emerald Airlines UK Limited | Transport & logistics | 2021 |
| Emerald Asset Holdings Ltd | Real estate | 2024 |
| Emerald Farms Ltd | Wholesale & retail | 2023 |
| Emerald Freight Express UK Limited | Transport & logistics | 2018 |
| Emerald International Trading Limited | Wholesale & retail | 2019 |
| Emerald Isle Paints Ltd | Wholesale & retail | 2020 |
| EMG Contracts Ltd | Professional & scientific | 2025 |
| Eminence Corporation Limited | Wholesale & retail | 2022 |
| EMK Trading Limited | Wholesale & retail | 2017 |
| Emlagh Construction Ltd | Construction | 2012 |
| Emma Quinn Design Ltd | Wholesale & retail | 2021 |
| Emmex Developments Limited | Construction | 2025 |
| Emmex Plant Sales Ltd | Administrative & support | 2020 |
| Empire by Turgut Ltd | Other services | 2026 |
| Empire Retail & Trade Ltd | Wholesale & retail | 2025 |
| Empire Systems L.P. | | 2015 |
| Empyrean Fields Limited | Extraterritorial | 2024 |
| Emra Homes Limited | Real estate | 2018 |
| Emrale Law Ltd | Professional & scientific | 2023 |
| Enable Care Services | Education | 2006 |
| Enda Hughes Ltd | Agriculture & fishing | 2020 |
| Enda Rogers Ltd | Construction | 2025 |
| Endeavour Estate Planning Ltd | Professional & scientific | 2024 |
| Energair Ltd | Energy | 2011 |
| Energy Switchgear IRE Ltd | Manufacturing | 2019 |
| Enermass Limited | Energy | 2025 |
| Enfa Ltd | Water & waste | 2020 |
| Engineering & Construction Limited | Manufacturing | 2013 |
| Engineering Inspections (Ireland) Ltd | Professional & scientific | 2016 |
| Engraved Gifts Ltd | Wholesale & retail | 2018 |
| Enhanced Aesthetics and Skincare Clinic Ltd | Health & social care | 2020 |
| Enhanced Hair Studio Ltd | Other services | 2017 |
| Enola Private Clinic Ltd | Other services | 2021 |
| ENS Contracts Ltd | Construction | 2025 |
| Enterprise Imaging Systems UK Limited | Information & communication | 2020 |
| Enterwood L.P. | | 2017 |
| Enviro Farm Environmental Ltd | Water & waste | 2021 |
| Enviro Farm Fertilisers Ltd | Manufacturing | 2021 |
| Enviro Farm Group Ltd | Financial services | 2021 |
| Enviro Farm Ltd | Water & waste | 2013 |
| Enviro Fire Water & Air Limited | Energy | 2015 |
| Enviroform Solutions Ltd | Construction | 2010 |
| Envirogreen Polymers Limited | Water & waste | 2012 |
| Envirogreen Waste Solutions Ltd | Water & waste | 2020 |
| Environmental Products and Services Ltd | Manufacturing | 1998 |
| Enzo Performance Ltd | Education | 2024 |
| Enzo TDF | Professional & scientific | 2016 |
| Enzy IQ Limited | Professional & scientific | 2025 |
| Eoin Smith Limited | Extraterritorial | 2013 |
| EOS Elite Ltd | Wholesale & retail | 2024 |
| Eosb Ltd | Construction | 2016 |
| EP Developments (Ireland) Limited | Construction | 2022 |
| Epfon Limited | Wholesale & retail | 2024 |
| EPG Quantity Surveying Limited | Professional & scientific | 2012 |
| EPK Properties Limited | Real estate | 2026 |
| Epractice Ltd | Wholesale & retail | 2025 |
| Equestrian Competitions Ltd | Agriculture & fishing | 2020 |
| Equine Suppliments Ltd | Professional & scientific | 2026 |
| Equipment Service & Repairs Limited | Manufacturing | 2013 |
| Equireel Ltd | Information & communication | 2022 |
| Equisent Ltd | Public administration | 2025 |
| Equitrans Ltd | Transport & logistics | 2020 |
| Equus Innovation Ltd | Information & communication | 2021 |
| ER Hillcrest Limited | Agriculture & fishing | 2014 |
| Eric Trimble Limited | Agriculture & fishing | 2012 |
| Erin Construction Limited | | 2005 |
| Errigal Bay (NI) Ltd | Manufacturing | 2019 |
| ESD Ltd | Health & social care | 2024 |
| Eshwary Estates Ltd | Construction | 2026 |
| ESO Contracts Ltd | Construction | 2017 |
| Essexford UK Ltd | Manufacturing | 2023 |
| EST. 28 Ltd | Arts & recreation | 2021 |
| Esther Women Limited | Information & communication | 2018 |
| Etain Atelier & Co. Ltd | Manufacturing | 2023 |
| Eternal Glow Aesthetics Ltd | Other services | 2025 |
| Etharla Entertainments Ltd | Arts & recreation | 2025 |
| Ethos Envirotech Ltd | Professional & scientific | 2014 |
| Eton Products L.P. | | 2017 |
| Etoncrieve Ltd | Real estate | 2016 |
| Eudia Technologies UK Limited | Professional & scientific | 2025 |
| Eugene NG Limited | Health & social care | 2014 |
| Eugil Limited | Real estate | 2016 |