| Soul and SEE Ltd | Health & social care | 2021 |
| Soul Arch Living Academy Ltd | Arts & recreation | 2024 |
| Soul Food Kitchen Newquay CIC | Hospitality | 2019 |
| Soul Gardening Newquay Ltd. | Administrative & support | 2020 |
| Soundworx Limited | Construction | 2003 |
| Source Nine Strategic Insights Ltd | Professional & scientific | 2021 |
| South West Backpackers Limited | Hospitality | 2002 |
| South West Eco Solutions Ltd | Construction | 2023 |
| Southern Star Electrical Ltd | Construction | 2025 |
| Southwestinns Limited | Hospitality | 2023 |
| Sowena Construction Ltd | Construction | 2022 |
| SP Capital Partners Limited | Wholesale & retail | 2026 |
| Specialist Plant South West Ltd | Manufacturing | 2016 |
| Specialized Exterior Cleaning Services Ltd | Administrative & support | 2021 |
| Spinnakers Management Company Limited | Households | 2004 |
| Splinters Limited | Construction | 2002 |
| Split Base Ltd | Hospitality | 2023 |
| Sportalingo Ltd | Education | 2026 |
| Spray Commercial Ltd | Construction | 2021 |
| Sprout Architectural LLP | | 2024 |
| Sprout Developments Limited | Construction | 2017 |
| SPS (Cornwall) Limited | Wholesale & retail | 2013 |
| Spud HUT NQY Ltd | Hospitality | 2025 |
| Squance & Co Limited | Other services | 2006 |
| ST 888 Limited | Hospitality | 2025 |
| ST Helieng Ltd | Manufacturing | 2024 |
| ST Mawgan Rally & Events CIC | Arts & recreation | 2023 |
| ST Michael's Gate Limited | Administrative & support | 2019 |
| ST Pirans of Crantock Ltd | Households | 2020 |
| ST. UNY Apartments (Carbis Bay) Management Company Limited | Extraterritorial | 2021 |
| Starancella Limited | Administrative & support | 2012 |
| Station Road (Cornwall) Management Company Limited | Households | 2008 |
| Steadfast Marine Limited | Transport & logistics | 2013 |
| Steele Securities Ltd | Real estate | 2021 |
| Steer Fishing (SW) Ltd | Agriculture & fishing | 2018 |
| Stellar Cleaning Services Ltd | Administrative & support | 2024 |
| Stepwynd Limited | Real estate | 2003 |
| Steren Mgmt Limited | Professional & scientific | 2022 |
| Sterncastle Hydrographic Ltd | Professional & scientific | 2021 |
| Steven Brown Financial Services Limited | Financial services | 2014 |
| Story Maker Events Ltd | Professional & scientific | 2018 |
| Strahand Property and Consulting Ltd | Real estate | 2023 |
| Strandline Ltd | Manufacturing | 2023 |
| Strawberry Yacht Management Limited | Administrative & support | 2011 |
| Street Wish Ltd | Wholesale & retail | 2021 |
| Streetwise Property UK Limited | Real estate | 2021 |
| Stuart Elliott Decorators Limited | Construction | 2016 |
| Studio 1218 Limited | Arts & recreation | 2019 |
| Subterandt Limited | Professional & scientific | 2012 |
| Sumart UK Limited | Wholesale & retail | 2025 |
| Summer Salt Cornwall Ltd | Manufacturing | 2026 |
| Summercourt MOT & Repair Centre Limited | Wholesale & retail | 2025 |
| Summercourt Scrap Yard Limited | Water & waste | 2012 |
| Summercourt Storage Limited | Transport & logistics | 2015 |
| Summerhill Property Lettings Ltd | Real estate | 2022 |
| Summers & Summers Limited | Other services | 2007 |
| Sun Circle Meadows Ltd | Hospitality | 2023 |
| Sunny and Beau Ltd | Wholesale & retail | 2023 |
| Sunnyside Park Limited | Real estate | 2018 |
| Sunpower Solar Limited | Energy | 2014 |
| Sunscreen Social Limited | Professional & scientific | 2025 |
| Sunset Apartments Limited | Households | 2008 |
| Sunset Surf Co Ltd | Wholesale & retail | 2024 |
| Supermoo Ltd | Information & communication | 2025 |
| Surf Communications Limited | Information & communication | 2009 |
| Surf Fit Ltd | Education | 2018 |
| Surf Media CIC | Education | 2024 |
| Surf View Limited | Households | 1999 |
| Surf View Newquay Ltd | Real estate | 2024 |
| Surfboards UK Limited | Manufacturing | 2018 |
| Surgassists Ltd | Information & communication | 2024 |
| Swan Court Management Truro Ltd | Households | 2014 |
| Swanky Seafood Limited | Hospitality | 2025 |
| Swanson Geophysical Services Limited | Professional & scientific | 1997 |
| Swbroadband Ltd | Information & communication | 2014 |
| Swis Distribution Ltd | Professional & scientific | 2012 |
| Swis Holdings Limited | Financial services | 2018 |
| Sycamore Gardens Management Limited | Water & waste | 2006 |
| Synctec Limited | Information & communication | 2016 |
| T F Resources Limited | Transport & logistics | 2013 |
| T Hall Quantity Surveyors Ltd | Professional & scientific | 2020 |
| T K Developments (Cornwall) Limited | Hospitality | 2013 |
| T&J Masonry Ltd | Construction | 2025 |
| Taggart Legal Services Limited | Professional & scientific | 2010 |
| Taggart Property Services Limited | Hospitality | 2023 |
| Talent 27 Ltd | Administrative & support | 2023 |
| Talkmanor Limited | Wholesale & retail | 2009 |
| Tangerine Leaves Ltd | Information & communication | 2023 |
| TANGO3 Ltd | Professional & scientific | 2020 |
| Tank Lettings Ltd | Real estate | 2024 |
| Tannin and Tide Ltd | Agriculture & fishing | 2025 |
| Tartan Tasty Limited | Hospitality | 2023 |
| Taygo Limited | Information & communication | 2019 |
| Taylor & Croft Contracting Ltd | Construction | 2025 |
| Taylor & Croft Scaffolding Ltd | Construction | 2026 |
| Taylor Made Tempura Ltd | Hospitality | 2020 |
| TCS Newquay Ltd | Other services | 2024 |
| Tea & Therapy Ltd | Manufacturing | 2018 |
| Team Maintenance Services Limited | Administrative & support | 2005 |
| Techichef Ltd | Information & communication | 2024 |