| Shine on Exterior Cleaning Ltd | Administrative & support | 2024 |
| Shire House Solutions Ltd | Administrative & support | 2014 |
| Shiva Nursing Home Limited | Health & social care | 1998 |
| Shivom Enterprise Ltd | Wholesale & retail | 2014 |
| Shoboraj Properties Limited | Hospitality | 2019 |
| Shoc! Clothing Limited | Wholesale & retail | 2025 |
| Shoeobsession Ltd | Wholesale & retail | 2021 |
| Shola Peacemotors Ltd | Wholesale & retail | 2020 |
| Shompurno Ltd | Wholesale & retail | 2025 |
| Shop 4 Shoes Limited | Wholesale & retail | 2010 |
| Shop With Enny Ltd | Wholesale & retail | 2025 |
| SHOP2HOUSES Group Ltd | Wholesale & retail | 2026 |
| Shopezyy Limited | Wholesale & retail | 2025 |
| Shopping at Fitzalan Limited | Wholesale & retail | 2017 |
| Short's Scaffolding Services Ltd | Construction | 2025 |
| Shorwell Pubs Limited | Hospitality | 2022 |
| Shrh Properties Ltd | Real estate | 2026 |
| Shri Shyamji Limited | Wholesale & retail | 2025 |
| Shropshire Autohaus Ltd | Wholesale & retail | 2025 |
| Shropshire Engineering Supplies Ltd | Wholesale & retail | 2012 |
| Shropshire Farm Services Ltd | Agriculture & fishing | 2025 |
| Shropshire Heating & Renewables Ltd | Construction | 2022 |
| Shropshire Lock & Safe Ltd | Manufacturing | 2010 |
| Shropshire Petals Limited | Agriculture & fishing | 2011 |
| Shropshire Taverns Limited | Hospitality | 2017 |
| Shropshire Wills Ltd | Professional & scientific | 2019 |
| Shropshire Woodchip Limited | Wholesale & retail | 2017 |
| SHS Global Ecommerce Ltd | Wholesale & retail | 2025 |
| Shubh Developments Ltd | Real estate | 2025 |
| Shutt & Mansell Limited | Agriculture & fishing | 2012 |
| Shuzavi Limited | Wholesale & retail | 2026 |
| Shylia Limited | Financial services | 2025 |
| Sibli AI Limited | Administrative & support | 2024 |
| Sideas Limited | Administrative & support | 2008 |
| Sideastech Limited | Professional & scientific | 2021 |
| Sidrive Limited | Hospitality | 2015 |
| Siemens Architecture Ltd | Professional & scientific | 2023 |
| Sight-Innovation Ltd | Information & communication | 2025 |
| Signal Flow Ltd | Construction | 2018 |
| Signatura Limited | Other services | 1996 |
| Signature Kitchens (IW) Ltd | Wholesale & retail | 2016 |
| Signature Roofing International Ltd | Construction | 2025 |
| Signature Strength Ltd | Arts & recreation | 2013 |
| Signature Upgrade Ltd | Wholesale & retail | 2026 |
| Signcore Limited | Households | 1990 |
| Signposted Cymru Ltd | Health & social care | 2021 |
| Sihha.Health Ltd | Wholesale & retail | 2024 |
| Sikka Investments Ltd | Financial services | 2016 |
| Silicon Digital Group Ltd | Information & communication | 2019 |
| Siloc Healthcare Limited | Health & social care | 2014 |
| Silurian Hotel Trading Ltd | Hospitality | 2023 |
| Silurian Ltd | Construction | 2026 |
| Silurian WAR Games Limited | Wholesale & retail | 2008 |
| Silvaria Ltd | Information & communication | 2025 |
| Silver Brook Health Ltd | Wholesale & retail | 2026 |
| Silver Control Ltd | Professional & scientific | 2023 |
| Silver Mountain Accountancy Limited | Professional & scientific | 2016 |
| Silvercrest Solutions Limited | Administrative & support | 2025 |
| Silverkey Property Investment Ltd | Real estate | 2025 |
| SIM Cards UK Ltd | Wholesale & retail | 2023 |
| SIM U Golf Ltd | Wholesale & retail | 2024 |
| SIM U Rentals Limited | Administrative & support | 2024 |
| Sim&Mid Properties Ltd | Real estate | 2025 |
| Simark Ltd. | Real estate | 2007 |
| Simbig (MEP Quantity Surveying) Ltd | Professional & scientific | 2024 |
| Simbolt Electrical Ltd | Construction | 2022 |
| Simec Energy Holdings 1 Ltd | Energy | 2016 |
| Simec Energy Holdings 2 Ltd | Energy | 2016 |
| Simec Energy Holdings 3 Ltd | Energy | 2016 |
| Simec Energy Holdings 4 Ltd | Energy | 2016 |
| Simec Energy Holdings 5 Ltd | Energy | 2017 |
| Simec Energy Solutions Limited | Energy | 2015 |
| Simec International (UK) Limited | Wholesale & retail | 2011 |
| Simec Ports (UK) Limited | Transport & logistics | 1995 |
| Simec Power 1 Limited | Energy | 2016 |
| Simec Power 2 Limited | Energy | 2016 |
| Simec Power 3 Limited | Energy | 2016 |
| Simec Power 4 Limited | Energy | 2016 |
| Simec Power 6 Limited | Energy | 2016 |
| Simec Shipping UK Ltd | Transport & logistics | 2017 |
| Simec Transport Limited | Transport & logistics | 1948 |
| Simec Wind One Ltd | Energy | 2016 |
| Simga Coaching Limited | Arts & recreation | 2025 |
| Simi's Kitchen Limited | Hospitality | 2024 |
| Simian Gait Limited | Information & communication | 2024 |
| Simmonds Motor Vehicle Repairs Limited | Wholesale & retail | 2015 |
| Simo Build Limited | Construction | 2021 |
| Simon Danaher CGI Ltd | Professional & scientific | 2012 |
| Simon Davies Machinery Repairs Limited | Manufacturing | 2015 |
| Simon Denness Architecture Limited | Professional & scientific | 2015 |
| Simon Evans Holdings Limited | Financial services | 2025 |
| Simon Gregory Ltd | Extraterritorial | 2022 |
| Simon Matthew Gregory Ltd | Extraterritorial | 2022 |
| Simon Rogers GAS Plumbing & Heating Services Ltd | Construction | 2023 |
| Simon Thomas Chinese Art Ltd | Wholesale & retail | 2023 |
| Simpacove Ltd | Wholesale & retail | 2025 |
| Simplebutclassic Limited | Transport & logistics | 2023 |
| Simply Bulk Limited | Transport & logistics | 2020 |
| Simply Lettings (S.W) Ltd | Real estate | 2026 |
| Simply Natural Aesthetics Ltd | Health & social care | 2022 |