| RMD Nails Ltd | Other services | 2026 |
| RML Inspection Services Limited | Professional & scientific | 2011 |
| RMM Bloodstock Ltd | Agriculture & fishing | 2026 |
| Rnapoleon Ltd | Hospitality | 2024 |
| Roamicoffee Ltd | Hospitality | 2026 |
| ROB Wright Mechanical Limited | Construction | 2010 |
| Robert Adams & Co Limited | Extraterritorial | 1985 |
| Robert Eddery Racing Limited | Arts & recreation | 2018 |
| Robert Hayes Ltd | Financial services | 2026 |
| Robinson Bloodstock Limited | Professional & scientific | 2016 |
| Rocc Building Company Limited | Construction | 2022 |
| Rokita M Ltd | Transport & logistics | 2021 |
| Romedine Limited | Professional & scientific | 2003 |
| Ronext Ltd | Transport & logistics | 2026 |
| Roof Solar Panels Limited | Manufacturing | 2025 |
| Rooh Ltd | Other services | 2026 |
| Rookery Golden Limited | Hospitality | 2023 |
| Roots for Life (Norfolk) Ltd | Professional & scientific | 2016 |
| Rose & Jacobs Consultancy’S Ltd | Construction | 2019 |
| Rose Hill Foot Health Ltd | Health & social care | 2023 |
| Roseboy Ltd | Administrative & support | 2017 |
| Rosehill Healthcare Limited | Health & social care | 2023 |
| Rosiebay Limited | Hospitality | 2023 |
| Rothwells Cleaning Services Ltd | Administrative & support | 2010 |
| Rowlands Engineers Limited | Extraterritorial | 1964 |
| Royale Homecare Limited | Health & social care | 2026 |
| RP Ltd | Extraterritorial | 2009 |
| RQ Limited | Extraterritorial | 2008 |
| RR Home&Garden Improvement Ltd | Construction | 2023 |
| RR Ltd | Extraterritorial | 2009 |
| Rsdj Property Ltd. | Real estate | 2018 |
| RTJ Management Limited | Professional & scientific | 2025 |
| Runham's Properties Ltd | Real estate | 2024 |
| RUNWAY23 Limited | Information & communication | 2014 |
| Rural Retreats Limited | Professional & scientific | 2012 |
| Rutland Hideaways Limited | Extraterritorial | 2024 |
| RV Limited | Extraterritorial | 2007 |
| RW Testing Ltd | Construction | 2023 |
| RWS Building & Landscapes Ltd | Construction | 2019 |
| S & a Property Development Limited | Households | 2024 |
| S & D K Agricultural Services Limited | Other services | 2003 |
| S & J Contracts Ltd | Real estate | 2003 |
| S Awbery Services Limited | Health & social care | 2022 |
| S Cowing Decorating Services Limited | Construction | 2022 |
| S Davis Plumbing and Heating Ltd | Construction | 2022 |
| S H Waste Management Limited | | 2012 |
| Saaten-Union (UK) Limited | Professional & scientific | 1997 |
| Sabro's Independent Food Limited | Hospitality | 2020 |
| Safain Labs Ltd | Information & communication | 2026 |
| Safety Release Limited | Wholesale & retail | 2011 |
| Sally Budd Limited | Professional & scientific | 2004 |
| Salt & Pepper Mortgages Limited | Financial services | 2024 |
| Saltwater Escapes Ltd | Administrative & support | 2021 |
| Sandalwood Group Ltd | Information & communication | 2021 |
| Sandra Byatt Hair & Beauty Ltd | Other services | 2025 |
| Sandy Lane (Cambridge) Limited | Real estate | 2015 |
| Santair Services Limited | Transport & logistics | 2017 |
| Sarah Oakley Lactation Limited | Health & social care | 2014 |
| Sarbri Limited | Wholesale & retail | 2020 |
| Sarteka Ltd | Transport & logistics | 2019 |
| Sata UK Limited | Wholesale & retail | 2006 |
| Saturday Ltd | Extraterritorial | 2021 |
| Savvy Property Buyer Ltd | Financial services | 2021 |
| SB Landscapes and Maintenance Ltd | Administrative & support | 2022 |
| SB Ltd | Extraterritorial | 2009 |
| SBM Life Science Ltd | Wholesale & retail | 2016 |
| SBR Tree & Landscape Contractors Ltd | Administrative & support | 2021 |
| Schmol Enterprises Ltd | Real estate | 2021 |
| Scimcon Limited | Administrative & support | 2003 |
| Scorcher Idea Limited | Manufacturing | 2002 |
| Scotch Curry Ltd | Hospitality | 2016 |
| Scotch Indian Ltd | Hospitality | 2023 |
| Scotto DI Carlo Ltd | Hospitality | 2025 |
| Scotts Eyecare Limited | Wholesale & retail | 2015 |
| SCT Property Limited | Real estate | 2021 |
| Scuderia LA Tesa Limited | Arts & recreation | 2021 |
| SD Ltd | Extraterritorial | 2009 |
| SDE Event Hire Limited | Hospitality | 2025 |
| SDM (Newmarket) Ltd | Construction | 2012 |
| SDS Construction & Tiling Limited | Construction | 2019 |
| Seasonal Spender Ltd | Information & communication | 2023 |
| Sebastian Brickwork Limited | Construction | 2015 |
| Sebastian Properties Limited | Real estate | 2020 |
| Secret Equine Ltd | Agriculture & fishing | 2024 |
| Secure Schools Ltd | Information & communication | 2018 |
| SEE Results Limited | Professional & scientific | 2012 |
| Select Assets Limited | Wholesale & retail | 2023 |
| Select Investments (London) Limited | Extraterritorial | 1987 |
| Select Outdoors Limited | Wholesale & retail | 2020 |
| Self Cater Cornwall Holidays Limited | Administrative & support | 2006 |
| Self Catered Meribel Ltd | Administrative & support | 2025 |
| Senyou Ltd | Information & communication | 2026 |
| SEP Shipping Consultancy Limited | Professional & scientific | 2025 |
| Serendipity Endeavours Limited | Hospitality | 2009 |
| Serendipity Herbals Ltd | Wholesale & retail | 2000 |
| Serv-Fix Ltd | Construction | 2023 |
| Several Estates Limited | Households | 2022 |
| SH Ltd | Extraterritorial | 2009 |
| Shadowlink Limited | Wholesale & retail | 2025 |
| Shankara (Newmarket) Limited | Administrative & support | 2021 |