| Omega 4X4 Ltd | Construction | 2019 |
| Only Consultancy Ltd | Financial services | 2013 |
| Only-Business Group Limited | Financial services | 2004 |
| Onstrada Limited | Information & communication | 2008 |
| Open HR Consulting Ltd | Administrative & support | 2021 |
| Openround Ltd | Information & communication | 2023 |
| OQ Traders Ltd | Wholesale & retail | 2025 |
| Orbec Design Limited | Professional & scientific | 2024 |
| Ostbridge Developments Limited | Extraterritorial | 2014 |
| Oupia Investments Limited | Professional & scientific | 2026 |
| Ouse Valley Investments Limited | Financial services | 2018 |
| Ouse Valley PUB & Wine Co Limited | Hospitality | 2008 |
| Oval Automation Limited | Manufacturing | 1994 |
| Overton & SON Ltd | Transport & logistics | 2019 |
| P and Y Flooring Investments Ltd | Financial services | 2025 |
| P&M Brickwork Ltd | Construction | 2014 |
| P&M Property and Lettings Ltd | Real estate | 2016 |
| P.H. 2002 Sovereign Management Ltd | Households | 2002 |
| Padella Doro Ltd | Hospitality | 2026 |
| Palmiye Property Ltd | Real estate | 2024 |
| Park Drive, Denton Residents Association Limited | Real estate | 1977 |
| Pats in Haven Ltd | Hospitality | 2026 |
| Paul COX Sculpture Ltd | Manufacturing | 2019 |
| Pecksniffs Lifestyle Ltd | Wholesale & retail | 2019 |
| Pegasus Scaffolding Ltd | Construction | 2010 |
| Peppys General Cleaning Limited | Administrative & support | 2025 |
| Perception Media Products & Services Ltd. | Professional & scientific | 2012 |
| Peripatus Ltd | Information & communication | 2007 |
| PG Digital Service Ltd | Information & communication | 2026 |
| Phaedra Games Ltd | Information & communication | 2019 |
| Phoenix Trading House Ltd | Wholesale & retail | 2025 |
| Picture Book Films Ltd | Information & communication | 2013 |
| Pine Court RTM Company Limited | Real estate | 2014 |
| PJ Clubs Ltd | Arts & recreation | 2024 |
| Plasticbuildersworks Ltd | Manufacturing | 2025 |
| Platformer Ltd | Professional & scientific | 2020 |
| Platinum Boxing Club Ltd | Arts & recreation | 2025 |
| Platinum Health & Fitness (UK) Limited | Arts & recreation | 2013 |
| Play on CIC | Education | 2019 |
| Playwell Productions CIC | Arts & recreation | 2020 |
| Plus 8 Digital Ltd | Wholesale & retail | 2018 |
| Poets House RTM Company Limited | Households | 2023 |
| Polegate Roofing Limited | Construction | 2002 |
| Ponies and Pups Limited | Wholesale & retail | 2026 |
| Poppadots Ltd | Arts & recreation | 2025 |
| Portway Teynham Ltd | Construction | 2007 |
| Prediabeatit Ltd | Health & social care | 2026 |
| Premier Impressions Limited | Manufacturing | 1989 |
| Primo Bodywork Repairs Ltd | Wholesale & retail | 2025 |
| Proudlocks Competitions Ltd | Arts & recreation | 2026 |
| Proudlocks MOT and Service Centre Ltd | Wholesale & retail | 2021 |
| Pupqx AI Cloud Ltd | Information & communication | 2025 |
| Pybus Group LLP | | 2018 |
| Pybus Property Limited | Real estate | 2019 |
| QPH (Seaford) RTM Company Limited | Real estate | 2017 |
| Quayside Antiques Limited | Manufacturing | 2004 |
| Queens Park Villa Management Company Limited | Real estate | 2016 |
| Quintessential English Designs Limited | Professional & scientific | 1997 |
| R & D Management Consultants Limited | Professional & scientific | 2012 |
| R & M Accountancy Limited | Extraterritorial | 2014 |
| R Giggs Electrical Ltd | Construction | 2026 |
| R P Professional Telehandler Limited | Construction | 2017 |
| Railtech Solutions Ltd | Professional & scientific | 2024 |
| Ramo Property Ltd | Real estate | 2023 |
| Rampion Limited | Health & social care | 2011 |
| Rappo Healthcare Limited | Health & social care | 2023 |
| Rappor Ltd | Information & communication | 2025 |
| RCB Studio Ltd | Professional & scientific | 2026 |
| Real Empire Ltd | Wholesale & retail | 2015 |
| Red 05 Ltd | Professional & scientific | 2017 |
| Red 5 Processing Ltd | Manufacturing | 2025 |
| Redwood Studios Limited | Arts & recreation | 1977 |
| Reebo Developments Ltd | Construction | 2016 |
| Reebo Scaffolding Limited | Construction | 2003 |
| Regal Electrical Sussex Ltd | Construction | 2026 |
| Renewable Revolution Ltd | Professional & scientific | 2023 |
| Rideaway Travel Limited | Transport & logistics | 2014 |
| Rima Housing Ltd | Real estate | 2025 |
| RNC Refurbishment Limited | Construction | 2008 |
| Roam Retreats Ltd | Hospitality | 2021 |
| Rockhopper Developments Ltd | Construction | 2026 |
| Roger Westgate Transport Ltd. | Transport & logistics | 2020 |
| Rottingdean Beauty Limited | Other services | 2026 |
| Rushey Hill Limited | Financial services | 2020 |
| RW Reselling Ltd | Wholesale & retail | 2026 |
| S K R Construction Group Ltd | Real estate | 2026 |
| S M Process Limited | Public administration | 2023 |
| Saffrons Court (Eastbourne) Limited | Real estate | 1981 |
| Sage Herbal Medicine Ltd | Health & social care | 2025 |
| Sama South Coast Ltd | Arts & recreation | 2026 |
| Samy Homes Limited | Real estate | 2018 |
| Samy Solutions Ltd | Professional & scientific | 2023 |
| Sand and City Property Holdings Ltd | Construction | 2024 |
| Saxon Heating Services Ltd | Construction | 2022 |
| Scott Workshops Limited | Manufacturing | 2003 |
| Sculpting Masterclass Limited | Arts & recreation | 2020 |
| Sdjsfitgroup Ltd | Arts & recreation | 2025 |
| Seaford Town Football Club Ltd | Arts & recreation | 2019 |
| Seaford(Hamilton House)Managements Limited | Households | 1969 |
| Seagull Service Stations Ltd | Wholesale & retail | 1987 |