| Franklin Commercial Finance Ltd | Financial services | 2018 |
| Franklin Holiday Lets Ltd | Real estate | 2024 |
| Fraser Analytics Ltd | Information & communication | 2026 |
| Fraser Electrical Solutions Limited | Construction | 2020 |
| Fraser for Fencing Ltd | Administrative & support | 2022 |
| Fraser Grant Estates Limited | Construction | 1983 |
| Fraser Meats(Ne) Ltd | Wholesale & retail | 2021 |
| Fratellanza Property Ltd | Real estate | 2022 |
| Frayed Clothing Limited | Manufacturing | 2025 |
| Frazer Sexton Hair Ltd | Other services | 2025 |
| Frecker Limited | Wholesale & retail | 1995 |
| Fred Smith & Sons (Newcastle) Ltd | Transport & logistics | 2015 |
| Freebird Solutions Limited | Information & communication | 2010 |
| Freelance Trader Limited | Wholesale & retail | 2024 |
| Freeman Homes (NE) Ltd | Construction | 2020 |
| Freeman King Limited | Manufacturing | 1996 |
| Freeman's Choice Ltd | Administrative & support | 2020 |
| Freeman,Morrison Limited | | 1946 |
| Freemanpharma Ltd | Health & social care | 2025 |
| Freemans Solicitors LLP | | 2018 |
| Freeway Properties Ltd | Real estate | 1998 |
| Freight Broker Services Limited | Transport & logistics | 2004 |
| Freightair Limited | Transport & logistics | 1985 |
| Freightline Carriers Holdings Ltd | Financial services | 2026 |
| Frelo CIC | Wholesale & retail | 2025 |
| French & Brown Ltd | Wholesale & retail | 2015 |
| French Court Management Company Limited | Households | 2001 |
| French Engineering (NE) Ltd | Real estate | 2018 |
| Frequasense Limited | Professional & scientific | 2020 |
| Fresco Enterprises Ltd | Wholesale & retail | 2024 |
| Fresh Artisan Bread Company Limited | Manufacturing | 2017 |
| Fresh Beauty Academy Ltd | Education | 2019 |
| Fresh Element Limited | Hospitality | 2004 |
| Fresh Element Management Limited | Hospitality | 2016 |
| Fresh Element Sill Limited | Hospitality | 2017 |
| Fresh Eyes Engineering Ltd | Professional & scientific | 2020 |
| Fresh Fruit&Veg Foresthall Ltd | Agriculture & fishing | 2025 |
| Fresh N Chips Ltd | Manufacturing | 2025 |
| Fresh Sky Ltd | Hospitality | 2021 |
| FRESH25 Ltd | Wholesale & retail | 2025 |
| Freshh Creative Limited | Professional & scientific | 2004 |
| Freshly Prepped Ltd | Manufacturing | 2018 |
| Frew Pain & Partners Limited | Real estate | 2010 |
| Freyr MAX Limited | Information & communication | 2025 |
| Friars House Management Limited | Real estate | 2026 |
| Friarstone Ltd | Real estate | 2026 |
| Friendly Assist Accountancy Ltd | Professional & scientific | 2024 |
| Friendoscopy Ltd | Health & social care | 2021 |
| Friends of Jesmond Library | Arts & recreation | 2013 |
| Friends of Wansbeck Road Shops CIC | Other services | 2025 |
| Friends Upholstery Ltd | Other services | 2019 |
| Friez&Burgz Byker Ltd | Hospitality | 2022 |
| Friez&Burgz CLS Limited | Hospitality | 2025 |
| Friez&Burgz Cowgate Ltd | Hospitality | 2022 |
| Friez&Burgz Express Ltd | Manufacturing | 2023 |
| Friez&Burgz Forest Hall Ltd | Hospitality | 2022 |
| Frincon Holdings 1986 Limited | Construction | 1986 |
| Fritzy | Households | 2019 |
| Froberg and Ogilvie Ltd | Professional & scientific | 2010 |
| Frodingham Coaches Limited | Extraterritorial | 1987 |
| Frogjam Motorsport Ltd | Manufacturing | 2023 |
| Front ROW Butchery Ltd | Manufacturing | 2025 |
| Frontier NCL Ltd | Hospitality | 2019 |
| Frontline Collections Ltd | Administrative & support | 2024 |
| Frontline Homecare Ltd | Health & social care | 2025 |
| Frontline Medical & Training Ltd | Health & social care | 2016 |
| Frontline Medical Ambulance Service Ltd | Health & social care | 2018 |
| Frost Carpets Ltd | Wholesale & retail | 2008 |
| Frost Commercials (Trade Sales) Limited | Wholesale & retail | 1997 |
| Frost Services (NE) Ltd | Other services | 2022 |
| Frost Van Centre Limited | Extraterritorial | 2016 |
| Frosty's NE Limited | Hospitality | 2026 |
| Frozeon Refrigeration Ltd | Manufacturing | 2024 |
| Fry's NE Ltd | Hospitality | 2025 |
| FS Props Ltd | Construction | 2026 |
| FS7 Limited | Information & communication | 2026 |
| Fscn Ltd | Administrative & support | 2024 |
| FSG (Hartlepool) Limited | Wholesale & retail | 2020 |
| Fsne Medical Limited | Transport & logistics | 2019 |
| Fswy Ltd | Administrative & support | 2024 |
| FT Flooring Solutions Ltd | Construction | 2019 |
| FT Garage Limited | Wholesale & retail | 2023 |
| FTM Enterprises Ltd | Manufacturing | 2011 |
| FTN Consultancy Ltd | Professional & scientific | 2022 |
| FTS BIO Limited | Wholesale & retail | 2013 |
| FTT Constructions Limited | Construction | 2023 |
| FTW Academy Community Interest Company | Education | 2019 |
| Fuel Research Ltd | Professional & scientific | 2024 |
| Fueledge Ltd | Wholesale & retail | 2025 |
| Fuelwise 1 Ltd | Wholesale & retail | 2025 |
| Fulani African Food Distributor Ltd | Wholesale & retail | 2025 |
| Full Blown Metals Ltd | Arts & recreation | 2013 |
| Full Forge Limited | Information & communication | 2020 |
| Full House Carpets Ltd | Wholesale & retail | 2025 |
| Full House Financial Limited | Financial services | 2021 |
| Full Square Networks Limited | Manufacturing | 2020 |
| Fully Accessible Breaks Ltd | Hospitality | 2022 |
| Fully Loaded Pictures Limited | Information & communication | 2024 |
| FUN Fit Adventure Ltd | Wholesale & retail | 2018 |
| FUN Flies Ltd | Wholesale & retail | 2022 |