| ES Locums Ltd | Health & social care | 2024 |
| Esadaqah.Org | Other services | 2019 |
| Escape to the North Limited | Real estate | 2023 |
| Escobar Vape Shop Ltd | Wholesale & retail | 2025 |
| Escucha Limited | Education | 2021 |
| ESE Welding Systems Limited | Manufacturing | 2019 |
| Esenler Ltd | Hospitality | 2019 |
| Esensi Skincare Ltd | Manufacturing | 2017 |
| ESK Valley Coaches Limited | Transport & logistics | 2002 |
| Eskdale Investments Northern Limited | Extraterritorial | 2024 |
| Eskdale Mansions Maintenance Limited | Households | 1975 |
| Eslington Spirits Limited | Manufacturing | 2021 |
| Eslington Technical Consultancy Limited | Information & communication | 1992 |
| ESP Management Limited | Professional & scientific | 1981 |
| ESP Media Limited | Information & communication | 2012 |
| Espresso Park Ltd | Hospitality | 2018 |
| Esprit Energy Ltd | Other services | 2018 |
| Esptr Limited | Wholesale & retail | 2024 |
| ESSAY91 Limited | Wholesale & retail | 2023 |
| Essence Healthcare Services Ltd | Health & social care | 2023 |
| Essendene Residential Management Company Limited | Real estate | 2018 |
| Essential Cremation Limited | Other services | 2025 |
| Essential DJS Limited | Arts & recreation | 2013 |
| Essential Funerals Northumberland Limited | Other services | 2025 |
| Essential Plumbing & Heating NE Limited | Construction | 2026 |
| Essential Services & Spiritual Enterprise Limited | Health & social care | 2013 |
| Esskay Group Limited | Financial services | 2026 |
| Estate Management 88 Limited | Real estate | 2000 |
| Estate Tea Merchants (Wholesale) Ltd | Wholesale & retail | 2024 |
| Estate Wills Limited | Professional & scientific | 2016 |
| Estates and Avenues Ltd | Real estate | 2018 |
| Esthétique by Noreen Ltd | Other services | 2025 |
| Esthétique Ltd. | Education | 2025 |
| Estudie MAS Limited | Administrative & support | 2022 |
| ET Business Funding Limited | Other services | 2012 |
| ET Investments Limited | Financial services | 2013 |
| ET Portfolio Company | Administrative & support | 2014 |
| Etaa Specific Limited | Wholesale & retail | 2024 |
| Eternal Web Ltd | Information & communication | 2022 |
| Ethelrise Ventures Ltd | Wholesale & retail | 2023 |
| Etheria Medical Ltd | Health & social care | 2020 |
| Etheridge Construction Ltd | Construction | 2018 |
| Ethica Construction Limited | Construction | 2021 |
| Ethical Healthcare Trustees Limited | Information & communication | 2022 |
| Ethical Human Resources Ltd | Professional & scientific | 2012 |
| Ethical Lets Limited | Real estate | 2021 |
| Ethos Health & Fitness Limited | Arts & recreation | 2005 |
| Ethosdent Exeter Limited | Health & social care | 2016 |
| Etjm Healthcare Ltd | Health & social care | 2025 |
| ETL Electrical Solutions Ltd | Construction | 2014 |
| Etle Ltd | Wholesale & retail | 2026 |
| Etrader Stores Limited | Information & communication | 2006 |
| Etro Developments Limited | Real estate | 2015 |
| Etro Group Ltd | Financial services | 2013 |
| Etro Investments Limited | Real estate | 2012 |
| Etro Lettings Limited | Real estate | 2023 |
| Etro Properties (Gosforth) Limited | Real estate | 2021 |
| Etro Properties (London) Limited | Real estate | 2018 |
| Etro Properties Limited | Real estate | 2011 |
| Ettleman Group Ltd | Information & communication | 2025 |
| Ettrick Lodge RTM Company Limited | Households | 2019 |
| Euclase Group Limited | Wholesale & retail | 2023 |
| Eudia Limited | Information & communication | 2025 |
| Eunice Wilkes Care Ltd | Administrative & support | 2021 |
| Euro Epos Ltd | Information & communication | 2016 |
| Euro Shop NE Ltd | Wholesale & retail | 2023 |
| Euro-Fin Partners Ltd | Other services | 2014 |
| Euro-Pfp Insight & Coaching (by Chris Fyfe) Ltd | Professional & scientific | 2026 |
| Euroconstruct Limited | Construction | 2022 |
| Euroelso Associates | Health & social care | 2012 |
| Euroelso Associates Enterprise Limited | Administrative & support | 2014 |
| Europa Roofing Services Limited | Wholesale & retail | 1985 |
| Europa Xpress Ltd | Transport & logistics | 2024 |
| European & Market Yellow Limited | Wholesale & retail | 2025 |
| European & Shop Limited | Wholesale & retail | 2025 |
| European Centre Human Rights Protection Roma Nation Ltd | Health & social care | 2026 |
| European Device Solutions Ltd | Professional & scientific | 2024 |
| European Social Franchising Network Ukeig | | 2008 |
| Europegate Food Ltd | Wholesale & retail | 2021 |
| Europlan Engineering UK Limited | Professional & scientific | 2022 |
| Europland Limited | Other services | 1997 |
| Eurospotter Ltd. | Other services | 2015 |
| Eurydice Games Ltd | Information & communication | 2018 |
| EVA Estates Ltd | Real estate | 2021 |
| EVA Ibbotson Estates Ltd | Information & communication | 2011 |
| Evaaraa Limited | Wholesale & retail | 2026 |
| Evangelical Holdings Ltd | Construction | 2024 |
| Evanwear Christian Clothing Ltd | Wholesale & retail | 2017 |
| Event Horizon Software Limited | Information & communication | 2025 |
| Event Legacies Limited | Professional & scientific | 2023 |
| Eventful Production Services Ltd | Professional & scientific | 2021 |
| Eventsheality Ltd | Professional & scientific | 2023 |
| Eventyx Ltd | Wholesale & retail | 2023 |
| Ever 1209 Limited | Extraterritorial | 1999 |
| Ever Trip Limited | Administrative & support | 2017 |
| Everbest Properties Ltd | Real estate | 2019 |
| Evergreen Care Residence Limited | Health & social care | 2025 |
| Evergreen Tattoo Studio Ltd | Other services | 2023 |
| Everslate Ltd | Wholesale & retail | 2026 |
| Everunity: Families Together Community Interest Company | Health & social care | 2025 |