| Emee Investments Limited | Real estate | 2024 |
| Emerald Gallery Ltd | Arts & recreation | 2022 |
| Emerald House 1 Limited | Real estate | 2017 |
| Emerald House 2 Limited | Real estate | 2017 |
| Emerald House 3 Limited | Real estate | 2017 |
| Emerald Moon Limited | Health & social care | 2016 |
| EMERALD4 Freight Limited | Health & social care | 2012 |
| Emeraldrx Limited | Wholesale & retail | 2024 |
| Emergency Electrician 247 Limited | Construction | 2023 |
| Emergency Plumber/Gas 24/7 Ltd | Construction | 2023 |
| Emergency Plumbing and Drainage Services Ltd | Construction | 2025 |
| Emfit UK Ltd | Extraterritorial | 2013 |
| EMG IT Services Limited | Information & communication | 2014 |
| Emgineering Limited | Professional & scientific | 2016 |
| Emily Scullion Architects Ltd | Professional & scientific | 2024 |
| Emily Sweetman Limited | Professional & scientific | 2011 |
| Emin Remzi Logistics Limited | Transport & logistics | 2026 |
| EMK GAS / Plumbing Services Ltd | Construction | 2020 |
| Emkare Ltd | Wholesale & retail | 2022 |
| Emkit Technologies Ltd | Professional & scientific | 2024 |
| Emma Nelson Events Limited | Administrative & support | 2024 |
| Emmanuel Oluwafemi Global Services Limited | Hospitality | 2023 |
| Emoola Ltd | Information & communication | 2015 |
| Emotional Logic Limited | Professional & scientific | 2007 |
| Empentis Limited | Professional & scientific | 2017 |
| Emperion Scientific EU Ltd. | Manufacturing | 2017 |
| Empire Estate Property Development Ltd | Real estate | 2025 |
| Empire Security NE Ltd | Administrative & support | 2019 |
| Empire Security North Ltd | Administrative & support | 2026 |
| Empires at WAR Ltd | Manufacturing | 2014 |
| Empirica Services LP | | 2017 |
| Emporium Flooring Ltd | Construction | 2023 |
| Emporium Leisure Group Limited | Hospitality | 2024 |
| Emporium Leisure Newcastle Limited | Real estate | 2025 |
| Emporium Leisure Newcastle Trading Limited | Hospitality | 2026 |
| Empower NE C.I.C. | Administrative & support | 2024 |
| Empowering Business Limited | Professional & scientific | 2019 |
| EMR Electrical Ltd | Construction | 2015 |
| EMS Performance Limited | Professional & scientific | 2016 |
| EMS Realisations Limited | Information & communication | 2005 |
| Emsp Ltd | Wholesale & retail | 2013 |
| Emvigr Limited | Information & communication | 2012 |
| EN KA 1 Ltd | Hospitality | 2025 |
| EN Route Foods Ltd | Wholesale & retail | 2017 |
| En-Akkore Health Solutions Ltd | Administrative & support | 2025 |
| En-Chan-Ted Foods Ltd | Hospitality | 2025 |
| Enablerry Solutions Ltd | Information & communication | 2024 |
| Enanchored Ltd | Other services | 2024 |
| Enayat Homestore Ltd | Wholesale & retail | 2022 |
| Enchanted Creations by Angel Limited | Manufacturing | 2021 |
| Enchanted Isles Limited | Information & communication | 2020 |
| Encompass Expert Services Ltd | Professional & scientific | 2023 |
| Encompass Technology Ltd | Manufacturing | 2013 |
| Encourage Coaching Ltd | Administrative & support | 2021 |
| Endeavour Investco Holdings Limited | Financial services | 2019 |
| Endeavour Investco Limited | Real estate | 2019 |
| Endeavour Management Solutions Limited | Professional & scientific | 2014 |
| Endeavour Retail Training Limited | Administrative & support | 2016 |
| Endeavours NCL Limited | Health & social care | 2023 |
| Endless 1 Limited | Hospitality | 2022 |
| Endless Crucible Ltd | Information & communication | 2026 |
| Endless Newcastle Limited | Hospitality | 2026 |
| Endless Stretch Limited | Real estate | 2014 |
| Endoxa Learning Ltd | Information & communication | 2018 |
| Endura Flat Roofing Limited | Construction | 2015 |
| Endura Roses GA Ltd | Wholesale & retail | 2019 |
| Endurance Automotive Services Limited | Wholesale & retail | 2025 |
| Endz OP3N Ltd | Wholesale & retail | 2023 |
| Energize GAS & Power Ltd | Administrative & support | 2023 |
| Energy Assistance Solutions Limited | Professional & scientific | 2018 |
| Energy BIZ Management Ltd | Professional & scientific | 2023 |
| Energy Claims Limited | Professional & scientific | 2020 |
| Energy Daddy Ltd | Construction | 2023 |
| Energy Kick Fitness Ltd | Extraterritorial | 2021 |
| Energy Link GAS Connections Limited | Energy | 2011 |
| Energy Professionals Centre Ltd | Extraterritorial | 2015 |
| Energy Solicitors Limited | Professional & scientific | 2022 |
| Energyworks Commercial Ltd | Other services | 2018 |
| Enerza Limited | Administrative & support | 2026 |
| Enes Demolation & Cleaning Ltd | Construction | 2020 |
| Enfinity Lifestyle Limited | Wholesale & retail | 2018 |
| ENG Consultancy Ltd | Professional & scientific | 2022 |
| Engage Education North East Ltd | Education | 2023 |
| Engenera Heating Limited | Construction | 2015 |
| Engine and Gearbox Exchange Limited | Transport & logistics | 1982 |
| Engineered Insulated Products (EIP) Ltd. | Manufacturing | 2013 |
| Engineered Solutions (Projects) Limited | Administrative & support | 2008 |
| Engineering and Consultancy Group Ltd | Construction | 2023 |
| Engineering Assessment Solutions Ltd | Professional & scientific | 2022 |
| Engineering Creatives Limited | Information & communication | 2013 |
| Engineering Property Services Limited | Manufacturing | 2010 |
| Engineering Subsea Ltd | Professional & scientific | 2019 |
| Engineeronics Limited | Professional & scientific | 2023 |
| English Partnerships (LP) Limited | Administrative & support | 2001 |
| Enguc Ltd | Information & communication | 2021 |
| Enhance by Anya Ltd | Other services | 2025 |
| Enhance Conservatories, Windows and Doors Limited | Construction | 2017 |
| Enhance NE Ltd | Professional & scientific | 2018 |
| Enhancial Digital Services Ltd | Information & communication | 2025 |
| Enigma Interactive Limited | Information & communication | 1997 |