| Cantina NCL Ltd | Hospitality | 2023 |
| Cantina Tequila Ltd | Hospitality | 2023 |
| Canton Delight (Redcar) Limited | Hospitality | 2012 |
| Canvas Beauty Bar Ltd | Other services | 2022 |
| Canvas Geeks Ltd | Manufacturing | 2012 |
| Cap-A-Pie Engagements | Arts & recreation | 2014 |
| Capa NE Ltd | Construction | 2026 |
| Capacity IT Ltd | Information & communication | 2026 |
| Capco Limited | Professional & scientific | 1991 |
| Cape Investment Group Ltd | Financial services | 2026 |
| Capital 4 Group Limited | Extraterritorial | 2012 |
| Capital 4 Holdings Limited | Extraterritorial | 2012 |
| Capital 4 Media Limited | Administrative & support | 2012 |
| Capital 4 Training Limited | Administrative & support | 2012 |
| Capital City Postering Ltd | Professional & scientific | 2025 |
| Capital Injection Ceramics Limited | Manufacturing | 2007 |
| Capital North East NO. 1 Limited Partnership | | 2002 |
| Capital Parent Limited | Professional & scientific | 2024 |
| Capital Properties Solutions Limited | Real estate | 2004 |
| Capitao-Smith Limited | Professional & scientific | 2016 |
| Capply Ltd | Information & communication | 2026 |
| Capquote Ltd | Information & communication | 2018 |
| Capra Construction Ltd | Construction | 2026 |
| Caprica Software Limited | Information & communication | 2007 |
| Capstaff Logistics Ltd | Transport & logistics | 2024 |
| Capstone Training Ltd | Professional & scientific | 2025 |
| Captain Brigade Ltd | Wholesale & retail | 2026 |
| Captain Pizza & Kebabs Ltd | Hospitality | 2022 |
| Captain Ted's Daycare Ltd | Health & social care | 2025 |
| Captain Teds Limited | Other services | 2010 |
| Capture Business Solutions Ltd | Information & communication | 2017 |
| Capture Interior Architecture Ltd | Professional & scientific | 2011 |
| Capture Stroke Limited | Information & communication | 2020 |
| Capture Your Vibe Ltd | Professional & scientific | 2025 |
| Capybara Imaging Limited | Health & social care | 2024 |
| Car Bazar Ltd | Wholesale & retail | 2023 |
| Car Cabin Ltd | Wholesale & retail | 2026 |
| Car Key Assist Ltd | Other services | 2022 |
| Car Keys NE Ltd | Wholesale & retail | 2025 |
| Car Repairs and Services (NE) Limited | Wholesale & retail | 2018 |
| Car Torque North East Limited | Manufacturing | 2014 |
| Carbon Costs Reduction Specialists Ltd | Professional & scientific | 2022 |
| Carbon Mania Ltd | Wholesale & retail | 2025 |
| Carbon Research Limited | Extraterritorial | 1982 |
| Carcraft Ltd | Wholesale & retail | 2026 |
| Card Consultant Services Limited | Financial services | 2025 |
| Card Station Limited | Wholesale & retail | 2018 |
| Cardiff Educational Endowment Trust | Administrative & support | 2008 |
| Cardiotrend Ltd | Health & social care | 2024 |
| Cards to Books Ltd | Wholesale & retail | 2025 |
| Care Abroad Ltd | Professional & scientific | 2026 |
| Care B&B Limited | Hospitality | 2024 |
| Care Management NE Limited | Health & social care | 2011 |
| Care Optics Limited | Wholesale & retail | 2003 |
| Care Staffing Services Limited | Administrative & support | 2023 |
| Careers.Plus Ltd | Information & communication | 2021 |
| Careline Group Holdings Limited | Financial services | 2025 |
| Careline Lifes LLP | | 2010 |
| Careline Lifestyles (UK) Ltd | Health & social care | 2006 |
| Carents Room CIC | Health & social care | 2025 |
| Caretap Ltd | Real estate | 2026 |
| Careview 360 Ltd | Information & communication | 2023 |
| Carew Dental Limited | Health & social care | 2021 |
| Carew Lettings Limited | Real estate | 2023 |
| Cargo Northeast Ltd | Transport & logistics | 2021 |
| Cargobay Ltd | Administrative & support | 2019 |
| Carigar Limited | Wholesale & retail | 2023 |
| Caring Technology Limited | Professional & scientific | 2007 |
| Carly FEE Funerals Ltd | Other services | 2023 |
| Carlyon Developments Ltd | Real estate | 2014 |
| Carm Digital Ltd | Wholesale & retail | 2025 |
| Carmania Ltd | Professional & scientific | 2009 |
| CARMELHOUSE17 Ltd | Hospitality | 2019 |
| Carms Illustrates Ltd | Wholesale & retail | 2024 |
| Carmy & Co Ltd | Real estate | 2025 |
| Carnage Entertainments Limited | Information & communication | 2023 |
| Carnation Homes Ltd | Real estate | 2025 |
| Carnegie Building Newcastle | Real estate | 2010 |
| Carnelian Place Limited | Wholesale & retail | 2022 |
| Carnelian Properties Ltd | Hospitality | 2024 |
| Carol a Hedland Associates Limited | Professional & scientific | 2017 |
| Carol Barwick Limited | Other services | 2014 |
| Carol Building Ltd | Construction | 2024 |
| Caroline Anderson IFA Ltd | Financial services | 2018 |
| Caroline Mews RTM Company Ltd | Real estate | 2010 |
| Carousel (NE) Limited | Wholesale & retail | 2016 |
| Carousel Buses Limited | Transport & logistics | 2000 |
| Carpet and Flooring (Newcastle) Ltd | Construction | 2021 |
| Carpet Discount Centre Limited | Wholesale & retail | 2011 |
| Carpet Studio (North East) Ltd | Wholesale & retail | 2016 |
| Carr Hill's Food Ltd | Hospitality | 2021 |
| Carr Trading International Limited | Wholesale & retail | 2024 |
| Carraway Finance Ltd | Financial services | 2000 |
| Carrey (Property & Investment) Co. | Real estate | 1960 |
| Carriage Jesmond Limited | Hospitality | 2018 |
| Carricks Corner Management Company Limited | Households | 2011 |
| Carrington James Limited | Administrative & support | 2020 |
| Carss Commercial Property Ltd | Real estate | 2024 |
| Carss Financial Partners Ltd | Financial services | 2017 |
| Carswell Academy Limited | Education | 2025 |