| WPS Advisory Ltd | Professional & scientific | 2014 |
| WPS Mechanical and Welded Engineering Ltd | Manufacturing | 2020 |
| WR Couriers Group Limited | Transport & logistics | 2025 |
| WR Properties NE Ltd | Real estate | 2024 |
| Wriggle Productions Limited | Information & communication | 2012 |
| Wright Brothers Limited | Real estate | 2022 |
| Wright Build NE Ltd | Construction | 2024 |
| Wright Event Services Ltd | Administrative & support | 2026 |
| Wright Fitness Coaching Limited | Other services | 2024 |
| Wright Hogg Eisen | | 1997 |
| Wright Street (Blyth) Management Company Limited | Real estate | 2005 |
| Wrights Technical Services Limited | Professional & scientific | 2012 |
| Wrighty's Ltd | Wholesale & retail | 2025 |
| Wrinton Limited | Real estate | 2011 |
| Write UP and Rise Ltd | Education | 2020 |
| WRITERS4U Ltd | Information & communication | 2016 |
| WS Healthcare Ltd | Professional & scientific | 2013 |
| WSN Properties Limited | Real estate | 2005 |
| WTC (North East) Limited | Wholesale & retail | 2011 |
| WTD Property Limited | Other services | 2015 |
| Wtdd Limited | Energy | 2026 |
| WTG Boxing Limited | Arts & recreation | 2026 |
| Wuff. UK Limited | Wholesale & retail | 2025 |
| Wujooh Clinic Ltd | Other services | 2025 |
| Wunderbar Festival C.I.C. | Arts & recreation | 2008 |
| WWN Pubs Limited | Hospitality | 2017 |
| Wwtr Ltd | Manufacturing | 2026 |
| Wyedale (Management) Limited | Real estate | 2007 |
| Wyepak (Holdings) Limited | Financial services | 2020 |
| Wylam Brewery Limited | Manufacturing | 2015 |
| Wylam Electrical Limited | Construction | 2019 |
| Wylam Manor (Wylam) Management Company Limited | Real estate | 2000 |
| Wyler Marketing Ltd | Professional & scientific | 2022 |
| Wynter Medical Ltd | Other services | 2025 |
| Wynyard Homes 2023 Limited | Construction | 2018 |
| Wynyard Homes Limited | Construction | 2011 |
| Wynyard Woods Management Limited | Real estate | 2002 |
| Wyre Music Ltd | Administrative & support | 2025 |
| X 92 Limited | Real estate | 2011 |
| X and L Tea Ltd | Hospitality | 2020 |
| X-Transport Management Solutions Ltd | Professional & scientific | 2024 |
| X7 Roofing Maintenance Ltd | Construction | 2016 |
| X92 Newcastle Limited | Hospitality | 2018 |
| XAL Kitchen Ltd | Hospitality | 2025 |
| Xander Property Limited | Real estate | 2018 |
| Xaptech Ltd | Information & communication | 2023 |
| Xbim Ltd. | Information & communication | 2016 |
| Xceda-Ai Ltd | Information & communication | 2021 |
| Xcel Technical Services Ltd | Construction | 2022 |
| Xclusiv Lounge and Restaurant Ltd | Hospitality | 2025 |
| Xcogai Ltd | Information & communication | 2025 |
| XDL Investment Ltd | Real estate | 2017 |
| Xeedo Ltd | Information & communication | 2025 |
| Xenex Food City Limited | Wholesale & retail | 2024 |
| Xenex Holdings Ltd | Wholesale & retail | 2019 |
| Xenex Properties Ltd | Real estate | 2025 |
| XG Express Limited | Hospitality | 2021 |
| Xian Biang Biang Noodle Ltd | Hospitality | 2026 |
| Xiang Ltd | Hospitality | 2017 |
| XIE and LIN Limited | Professional & scientific | 2011 |
| XIE JIN Limited | Hospitality | 2018 |
| Xinfluence Ltd | Information & communication | 2019 |
| XIS Wind Limited | Construction | 2025 |
| XJ Oncology & Insight Ltd | Professional & scientific | 2025 |
| Xkwizit Ltd | Construction | 2024 |
| Xoom Electronics Ltd | Other services | 2025 |
| XPE Eldon Square Merchants Association Limited | Wholesale & retail | 1978 |
| Xpert Web Studio Ltd | Information & communication | 2025 |
| Xplor Software (UK) Limited | Information & communication | 2000 |
| XR Ventures Ltd | Wholesale & retail | 2025 |
| XRB Engineering Consultants Ltd | Professional & scientific | 2026 |
| XRM Technical Limited | Professional & scientific | 2021 |
| Xsite Architecture LLP | | 2008 |
| Xsite Research Limited | Professional & scientific | 2019 |
| Xtras Security Networks Ltd | Administrative & support | 2019 |
| Xtravagant Limited | Real estate | 2001 |
| Xxx-Nutrition Ltd | Health & social care | 2011 |
| Y & H (NE) Ltd | Hospitality | 2021 |
| Y K Supermarket Limited | Wholesale & retail | 2022 |
| Y Mustafa Properties Ltd | Financial services | 2025 |
| Y NOT Productions Limited | Information & communication | 2021 |
| Y.A.P Bridal Ltd | Wholesale & retail | 2019 |
| Y3 Vehicles Ltd | Wholesale & retail | 2025 |
| Yadyfranks Medical Services Limited | Health & social care | 2023 |
| Yakeen Foods Ltd | Hospitality | 2026 |
| Yamas (NE) Ltd | Hospitality | 2015 |
| Yan-C Limited | Wholesale & retail | 2016 |
| Yana Ltd | Wholesale & retail | 2018 |
| Yang Yang UK Ltd | Wholesale & retail | 2013 |
| Yankee Food Trucks Limited | Extraterritorial | 2022 |
| Yardd Limited | Information & communication | 2023 |
| Yarm Management Company Limited | Real estate | 1994 |
| Yarm Mews Management Company Limited | Professional & scientific | 2007 |
| Yaro 55 Ltd | Other services | 2023 |
| Yaroo Limited | Other services | 2017 |
| Yashwantnvij Ltd | Transport & logistics | 2026 |
| Yasi's Cozy Home Ltd | Real estate | 2025 |
| Yasin Group Ltd | Hospitality | 2018 |
| Yasin.Ai Ltd | Information & communication | 2024 |
| Yasmina Café Ltd | Hospitality | 2023 |