| Two Little Monkeys Limited | Information & communication | 2005 |
| Two Pastures Limited | Real estate | 2025 |
| TWO22 Consulting Ltd | Information & communication | 2026 |
| Twoflatwhites Ltd | Hospitality | 2025 |
| Twoplustwo Commercial Services Limited | Administrative & support | 2007 |
| TWP Consultants Ltd | Professional & scientific | 2023 |
| Twri Research Limited | Information & communication | 2011 |
| TWS Hospitality Ltd | Hospitality | 2024 |
| Txtrax Ltd | Information & communication | 2004 |
| Txtwin Limited | Information & communication | 2003 |
| TY NET Solutions Limited | Wholesale & retail | 2023 |
| TY Veterinary Anaesthesia Ltd | Professional & scientific | 2023 |
| Tylaw Meadows Property Management Company Limited | Real estate | 2004 |
| Tyne & Tokyo Ltd | Manufacturing | 2025 |
| Tyne & Wear Foundation Limited | Health & social care | 2000 |
| Tyne & Wear Groundworks Ltd | Extraterritorial | 2025 |
| Tyne & Wear Investments Limited | Financial services | 2020 |
| Tyne & Wear Play Limited | Other services | 2015 |
| Tyne & Wear Security Limited | Administrative & support | 1990 |
| Tyne 1852 Limited | Hospitality | 2018 |
| Tyne and Wear (Stock 2) Limited | Construction | 2018 |
| Tyne and Wear Lettings Ltd | Real estate | 2022 |
| Tyne and Wear Property Management Ltd | Real estate | 2016 |
| Tyne and Wear Trading Limited | Wholesale & retail | 2020 |
| Tyne and Wear UK Ltd | Wholesale & retail | 2019 |
| Tyne Barber Ltd | Other services | 2026 |
| Tyne Beds Limited | Wholesale & retail | 2025 |
| Tyne Brew Ltd | Manufacturing | 2025 |
| Tyne Brickworks Ltd | Construction | 2026 |
| Tyne Bridging Limited | Financial services | 2019 |
| Tyne Carpets & Beds Limited | Wholesale & retail | 2020 |
| Tyne Cleaning Company Ltd | Administrative & support | 2024 |
| Tyne CUT & Core Limited | Construction | 2020 |
| Tyne Design & Print Ltd | Professional & scientific | 2026 |
| Tyne Ecology Limited | Professional & scientific | 2021 |
| Tyne Electro Diesel Limited | Manufacturing | 1990 |
| Tyne Energy Limited | Energy | 2022 |
| Tyne Enterprises Ltd | Wholesale & retail | 2013 |
| Tyne Estate Agents Ltd | Real estate | 2024 |
| Tyne Expert Trading Ltd | Wholesale & retail | 2016 |
| Tyne Gangway (Structures) Limited | Manufacturing | 2009 |
| Tyne Gangway Limited | Extraterritorial | 2009 |
| Tyne GAS Services Ltd | Construction | 2019 |
| Tyne Green Watersports Association | Arts & recreation | 2010 |
| Tyne Healthcare Connect Limited | Administrative & support | 2025 |
| Tyne Hotel Limited | Hospitality | 2022 |
| Tyne Land and Developments Ltd | Construction | 2023 |
| Tyne Lets Limited | Real estate | 2019 |
| Tyne Life-Boat Society(The) | Health & social care | 1905 |
| Tyne Machine Tool Services Ltd | Manufacturing | 2008 |
| Tyne Maritime Limited | Transport & logistics | 2025 |
| Tyne News 1 Limited | Wholesale & retail | 2020 |
| Tyne North Ltd | Construction | 2021 |
| Tyne Park Group Limited | Real estate | 2025 |
| Tyne Pressure Testing Limited | Professional & scientific | 2014 |
| Tyne Property Services Ltd | Real estate | 2022 |
| Tyne Region North Limited | Real estate | 1993 |
| Tyne Region North Properties Limited | Real estate | 2011 |
| Tyne River Properties Limited | Real estate | 2021 |
| Tyne Shield Security Ltd | Administrative & support | 2025 |
| Tyne Site Services Limited | Construction | 2015 |
| Tyne Spice Ltd | Wholesale & retail | 2025 |
| Tyne Taxis (Newcastle) Ltd | Transport & logistics | 2025 |
| Tyne Tees Inspection Services Ltd | Professional & scientific | 2019 |
| Tyne Tees Thermal Limited | Construction | 2006 |
| Tyne Thai Street Food Ltd | Wholesale & retail | 2025 |
| Tyne Theatre & Opera House Limited | Arts & recreation | 2014 |
| Tyne Theatre and Opera House Preservation Trust | Arts & recreation | 1999 |
| Tyne Therapy Ltd | Health & social care | 2023 |
| Tyne Threads Ltd | Manufacturing | 2024 |
| Tyne to Shine Limited | Administrative & support | 2025 |
| Tyne Tools Ltd | Wholesale & retail | 2025 |
| Tyne Trading LLP | | 2023 |
| Tyne Treats Limited | Hospitality | 2026 |
| Tyne Utilities Ltd | Professional & scientific | 2017 |
| Tyne Valley Electrical Ltd | Construction | 2025 |
| Tyne Valley Folk Train CIC | Arts & recreation | 2016 |
| Tyne Valley Holdings Limited | Administrative & support | 2019 |
| Tyne Valley Leisure Limited | Wholesale & retail | 2014 |
| Tyne Valley Nurseries Limited | Wholesale & retail | 1976 |
| Tyne Ventures Ltd | Real estate | 2020 |
| Tyne View Property Ltd | Real estate | 2024 |
| Tyne View Property Partnership Limited | Real estate | 2024 |
| Tyne View Sourcing Ltd | Real estate | 2025 |
| Tyne Water Family Company Ltd | Transport & logistics | 2020 |
| Tyne Wind Services Ltd | Professional & scientific | 2018 |
| Tynebridge Commercial Company Limited | Manufacturing | 2023 |
| Tynebridge Investments Limited | Real estate | 2004 |
| Tynedale Gardens Limited | Administrative & support | 2020 |
| Tynefast Holdings Ltd | Administrative & support | 2021 |
| Tynegate Estates Ltd | Real estate | 2026 |
| Tynegate Investments Limited | Real estate | 2022 |
| Tynegate Properties Ltd | Real estate | 2026 |
| Tynehead (Property) Limited | Real estate | 1907 |
| Tyneheart Limited | Real estate | 2002 |
| Tynelets Commercial Limited | Construction | 2019 |
| Tynelettings Ltd | Real estate | 2022 |
| Tynemouth CEC Limited | Wholesale & retail | 2022 |
| Tynemouth Gourmet Pies Ltd | Manufacturing | 2019 |
| Tynemouth Holdings (NE) Limited | Professional & scientific | 2023 |