| THE Recovery London Ltd | Health & social care | 2019 |
| THE Reece Foundation | Administrative & support | 2007 |
| THE Regency Practice Melksham Limited | Health & social care | 2018 |
| THE Reinventory Company Ltd | Information & communication | 2018 |
| THE Render Cleaning Company Limited | Administrative & support | 2017 |
| THE Renters Loft Limited | Real estate | 2023 |
| THE Retreat Whickham Limited | Other services | 2023 |
| THE Revamp Room Ltd | Other services | 2025 |
| THE Right Staff Team Limited | Administrative & support | 2015 |
| THE Ripple Effect Ltd | Education | 2022 |
| THE Road to Recovery Trust | Health & social care | 2011 |
| THE Roaring Lion Newcastle Ltd. | Information & communication | 2012 |
| THE Robson Family (Trust) Limited | Professional & scientific | 2010 |
| THE Rocket Social Ltd | Professional & scientific | 2025 |
| THE Rookery Limited | Extraterritorial | 2015 |
| THE Royston Practice Limited | Health & social care | 2017 |
| THE Ryan Leslie Almond Trust Limited | Real estate | 2023 |
| THE Sage Group PLC. | Professional & scientific | 1988 |
| THE Salon Story by Cheryl Moss Ltd | Other services | 2023 |
| THE Samadhi Nest Ltd | Health & social care | 2024 |
| THE Sands Group U.K Ltd | Professional & scientific | 2013 |
| THE Sardinian Adventure Limited | Hospitality | 2019 |
| THE Sayers Newcastle Limited | Information & communication | 2016 |
| THE Second Hsbc UK Enterprise Fund for the North East | | 1999 |
| THE Send Club CIC | Information & communication | 2026 |
| THE Serendipity Foundation Limited | Health & social care | 2014 |
| THE Shiremoor Fish & Grill Ltd | Hospitality | 2020 |
| THE Slow Hub Community Interest Company | Health & social care | 2026 |
| THE Smart Prices Ltd. | Wholesale & retail | 2017 |
| THE Smile High Club Ltd | Health & social care | 2018 |
| THE Sneaker Cleanic NE Limited | Other services | 2021 |
| THE Snoring Centre Limited | Health & social care | 2012 |
| THE Social Market Limited | Hospitality | 2016 |
| THE Social Pubco Ltd | Hospitality | 2021 |
| THE Social Syndicate Limited | Professional & scientific | 2022 |
| THE Society of Company and Commercial Accountants Limited | Other services | 1929 |
| THE South African Cafe Limited | Hospitality | 2022 |
| THE Spicery Indian Cuisine Ltd | Hospitality | 2024 |
| THE Spicy Biker Limited | Hospitality | 2023 |
| THE Sponsor Hub Ltd | Professional & scientific | 2018 |
| THE Spring of Life Christian Centre Limited | Other services | 2010 |
| THE Square Management Company (Fulwell) Limited | Real estate | 2006 |
| THE ST. Julian's Management Company Limited | Water & waste | 2005 |
| THE ST. Mary Magdalene and Holy Jesus Trustee Limited | Hospitality | 2008 |
| THE Staiths (Phase 4) Management Company Limited | Real estate | 2008 |
| THE Star Blanket Company Limited | Wholesale & retail | 2025 |
| THE Station Hotel (Newcastle) Limited | Hospitality | 1985 |
| THE Staycation Guys Ltd | Hospitality | 2026 |
| THE Steadings (Greensfield) Management Company Limited | Real estate | 2025 |
| THE Steep Curve Limited | Education | 2026 |
| THE Stitch Emporium Limited | Other services | 2023 |
| THE Storyteller Consultancy Ltd | Administrative & support | 2019 |
| THE Strawberry PUB Company Limited | Hospitality | 2002 |
| THE Summers Group Gosforth Limited | Real estate | 2018 |
| THE Summers Group Northumberland Limited | Real estate | 2020 |
| THE Summers Group Properties Limited | Extraterritorial | 2018 |
| THE Sun Lounge 10 Limited | Other services | 2025 |
| THE Sweetest Tooth Ltd | Manufacturing | 2023 |
| THE Swordmaker Ltd | Wholesale & retail | 2019 |
| THE Sycamores (Birtley) Limited | Extraterritorial | 2014 |
| THE Sycamores (Stockton) Management Company Limited | Real estate | 2020 |
| THE Sydenham Art Materials Ltd | Wholesale & retail | 2007 |
| THE Table Project CIC | Hospitality | 2025 |
| THE Taggles Collective Ltd | Wholesale & retail | 2026 |
| THE Tattoo Merch Guys Ltd | Wholesale & retail | 2024 |
| THE Three Donkeys Heaton Ltd | Wholesale & retail | 2025 |
| THE Three Group Limited | Real estate | 2014 |
| THE Thrift Side Ltd | Wholesale & retail | 2025 |
| THE Tides Cloisters Care Limited | Health & social care | 2017 |
| THE Tides Craignair Care Limited | Health & social care | 2017 |
| THE Tiling Company (Northern) Limited | Construction | 2008 |
| THE Tiny Development Co. Ltd | Construction | 2024 |
| THE Tiny Lives Trust | Health & social care | 2012 |
| THE Tiny Property Co. Ltd | Construction | 2023 |
| THE Tipsy Horse Ltd | Hospitality | 2017 |
| THE TMS Global Network Limited | Professional & scientific | 2019 |
| THE Top Wave Limited | Wholesale & retail | 2026 |
| THE Torogoz Ltd | Hospitality | 2024 |
| THE Towers Property Company Limited | Construction | 2015 |
| THE Town Mouse Eldon Ltd | Hospitality | 2025 |
| THE Town Mouse Heaton Ltd | Hospitality | 2022 |
| THE Town Mouse Newcastle Ltd | Hospitality | 2016 |
| THE Town Mouse Whitley Bay Ltd | Hospitality | 2026 |
| THE Townhouse Hotel Gosforth Limited | Hospitality | 2014 |
| THE Traidcraft Exchange | Other services | 1995 |
| THE Transcenders Trainings & Consultancy Limited | Information & communication | 2018 |
| THE Travel Crew UK Limited | Transport & logistics | 2013 |
| THE Traveller and the Bear Ltd | Professional & scientific | 2019 |
| THE Tree Rooms Ltd | Wholesale & retail | 2021 |
| THE Trendsetting Group Holdings Limited | Professional & scientific | 2008 |
| THE Trendsetting Group Limited | Manufacturing | 1979 |
| THE Trent House Limited | Hospitality | 2018 |
| THE True Potential Discretionary Trustee 2009 Limited | Financial services | 2008 |
| THE Turkish EYE Ltd | Other services | 2018 |
| THE Turnbull Freehold Company Limited | Real estate | 2013 |
| THE Turnbull RTM Company Limited | Households | 2009 |
| THE Turners Workshop Limited | Wholesale & retail | 2016 |
| THE Twist Group Limited | Professional & scientific | 2017 |
| THE Tynesider Ltd | Hospitality | 2024 |
| THE UK Padel Tribe Limited | Arts & recreation | 2026 |