| Newcastle Science Central Holdings Limited | Professional & scientific | 2006 |
| Newcastle Short Lets Ltd | Real estate | 2021 |
| Newcastle Short Stays Ltd | Hospitality | 2021 |
| Newcastle Shutter Company Limited | Wholesale & retail | 2021 |
| Newcastle Smoke Box Ltd | Wholesale & retail | 2020 |
| Newcastle Special Schools Trust | Education | 2013 |
| Newcastle Sports HIP Limited | Financial services | 2017 |
| Newcastle Sports Medicine Limited | Extraterritorial | 2015 |
| Newcastle Stays Ltd | Hospitality | 2026 |
| Newcastle Stephenson Works Holdings Limited | Financial services | 2020 |
| Newcastle Student Houses Limited | Real estate | 2013 |
| Newcastle Surface Cleaning Ltd | Administrative & support | 2016 |
| Newcastle Sweets (NE) Ltd | Hospitality | 2025 |
| Newcastle Swim Team | Arts & recreation | 2023 |
| Newcastle Taxis Limited | Transport & logistics | 2017 |
| Newcastle Theatre Royal Trust Limited | Arts & recreation | 1975 |
| Newcastle Thunder Ltd | Arts & recreation | 2023 |
| Newcastle Tiles and Adhesives Ltd | Wholesale & retail | 2014 |
| Newcastle Tiling Contractors Limited | Construction | 2018 |
| Newcastle Transport Ltd | Transport & logistics | 2024 |
| Newcastle Travel and Tours Ltd | Administrative & support | 2014 |
| Newcastle Turkish Centre CIC | Health & social care | 2017 |
| Newcastle Tyres NO 1 Ltd | Wholesale & retail | 2018 |
| Newcastle United Football Club Projects Limited | Construction | 2022 |
| Newcastle United Foundation | Administrative & support | 2007 |
| Newcastle United Foundation Projects Limited | Construction | 2016 |
| Newcastle United Sportswear Limited | Professional & scientific | 1996 |
| Newcastle United Supporters Club 2023 Ltd | Arts & recreation | 2023 |
| Newcastle United Women's Football Club Limited | Arts & recreation | 2018 |
| Newcastle Unity Group Limited | Professional & scientific | 2024 |
| Newcastle University Construction Company Limited | Construction | 2007 |
| Newcastle University Developments Limited | Other services | 1987 |
| Newcastle University Holdings Limited | Professional & scientific | 1995 |
| Newcastle University Pension Trustee (1971) Limited | Administrative & support | 2002 |
| Newcastle University Students' Union | Education | 2009 |
| Newcastle University Ventures Limited | Professional & scientific | 1988 |
| Newcastle Upon Tyne Chamber Music Society Limited | Arts & recreation | 1997 |
| Newcastle Upon Tyne Law Society | Other services | 1871 |
| Newcastle Upon Tyne Y.M.C.A. | Other services | 1998 |
| Newcastle Ventilation Services Limited | Wholesale & retail | 1973 |
| Newcastle Ventures Ltd | Wholesale & retail | 2023 |
| Newcastle Video Company Limited | Administrative & support | 2017 |
| Newcastle Wardrobe Company Ltd | Manufacturing | 2023 |
| Newcastle Weightlifting CIC | Other services | 2026 |
| Newcastle Wood Recycling Community Interest Company | Water & waste | 2013 |
| Newcastle Yoga School Limited | Education | 2019 |
| Newcastle-Upon-Tyne & District Property & Investment Co Limited(The) | Real estate | 1928 |
| Newcastlebuildingconstruction Limited | Construction | 2023 |
| Newcastlecare Ltd | Administrative & support | 2025 |
| Newcastlegatesheadproperties Ltd | Real estate | 2026 |
| Newex Group Limited | Arts & recreation | 2025 |
| Newford Estates Ltd | Real estate | 2003 |
| Newjeav Ltd | Construction | 2018 |
| Newland Electronics Limited | Wholesale & retail | 1985 |
| Newland Lettings & Maintenance Ltd | Real estate | 2020 |
| Newlands Services NE Ltd | Wholesale & retail | 2024 |
| Newmanite Consulting Ltd | Information & communication | 2024 |
| Newmarket Pre-Training Limited | Agriculture & fishing | 2015 |
| Newminster Place (Management Company) Limited | Real estate | 2003 |
| Newquay Holiday Parks Limited | Professional & scientific | 1978 |
| News Express Ltd | Wholesale & retail | 2022 |
| News Express Newcastle Ltd | Wholesale & retail | 2023 |
| News Transport Limited | Transport & logistics | 2002 |
| Newtec Security Solutions Limited | Administrative & support | 2012 |
| Newton Barns (Alnwick) Management Limited | Real estate | 2005 |
| Newton Cantonese Chop Suey House Ltd | Hospitality | 2019 |
| Newton Capital Consultants Ltd | Professional & scientific | 2024 |
| Newton Hall (Northumberland) Limited | Hospitality | 2006 |
| Newton Moor Construction Limited | Wholesale & retail | 1974 |
| Newton SS Ltd | Wholesale & retail | 2026 |
| Newtons Ladder Ltd | Arts & recreation | 2023 |
| Nexa FM Limited | Professional & scientific | 2026 |
| Nexahome Management Ltd | Real estate | 2025 |
| Nexewave Ltd | Information & communication | 2026 |
| Nexgen Coaching Ltd | Education | 2025 |
| Nexify Digital Ltd | Wholesale & retail | 2025 |
| Nexlley Limited | Wholesale & retail | 2026 |
| Nexoro Ltd | Wholesale & retail | 2023 |
| Next GEN Sport and Education Ltd | Education | 2025 |
| Next GEN Sports Camps Ltd | Education | 2016 |
| Next Level Developments Limited | Real estate | 1982 |
| Next Move Properties Limited | Real estate | 2007 |
| Next Opportunity Limited | Administrative & support | 2014 |
| NEXT2ME Ltd | Information & communication | 2024 |
| Nextedgeinfotech Ltd | Information & communication | 2026 |
| Nextgen Group Limited | Real estate | 2015 |
| Nexus Node Systems Ltd | Wholesale & retail | 2024 |
| Nexus Rise Ltd | Manufacturing | 2026 |
| Neztech Properties Ltd | Real estate | 2023 |
| Neztech Solutions Ltd | Information & communication | 2021 |
| NF Food Plus Limited | Wholesale & retail | 2015 |
| NFC (Beds) Ltd | Wholesale & retail | 2021 |
| NG Electric Limited | Construction | 2018 |
| NG Holding Group Limited | Financial services | 2022 |
| Ngai PE Ltd | Wholesale & retail | 2021 |
| NGI Solutions Limited | Professional & scientific | 2014 |
| NGP Management Company (Cell a) Limited | Real estate | 2019 |
| NGP Management Company (Cell D) Limited | Real estate | 2017 |
| NGP Management Company (Cell E) Limited | Real estate | 2016 |
| NGP Management Company (Cell F) Limited | Real estate | 2007 |