| Enbridge House Limited | Health & social care | 2025 |
| Endeavor Management Limited | Professional & scientific | 2008 |
| Endovia Ltd | Wholesale & retail | 2025 |
| Energis Communications Limited | Information & communication | 1991 |
| Energis Squared Limited | Information & communication | 1995 |
| Energy Geoservices Ltd | Mining & quarrying | 2022 |
| Energy Investment Spectrum Limited | Construction | 2016 |
| Energy Saving Experts Limited | Professional & scientific | 2007 |
| Enevoldsen Ltd | Professional & scientific | 2022 |
| Engage Global Solutions Limited | Administrative & support | 2012 |
| Engin Mobile Hairdresser Ltd | Other services | 2025 |
| Enola Holdings Limited | Information & communication | 2025 |
| Enola Midco Limited | Information & communication | 2025 |
| Ensco 1322 Limited | Professional & scientific | 2018 |
| Enso Circle Solutions Limited | Wholesale & retail | 2025 |
| Ensueno Limited | Construction | 1995 |
| Entegra Solutions Limited | Professional & scientific | 2014 |
| Enterprisers Nextlevels & Wellness Marketing Company Ltd | Administrative & support | 2022 |
| Eogrande 2017 Limited | Information & communication | 1998 |
| Eoservices Ltd | Information & communication | 2014 |
| EP Golf Media Ltd | Information & communication | 2023 |
| EPH System Limited | Construction | 2012 |
| Epitome Building & Renovation Ltd | Construction | 2021 |
| Epsera Ltd | Wholesale & retail | 2025 |
| Equestrian Marketplace Ltd | Wholesale & retail | 2024 |
| Equilance Ltd | Wholesale & retail | 2011 |
| Equine Hydrotherapy Association Limited | Administrative & support | 2019 |
| Equiperformance Limited | Administrative & support | 2016 |
| Equus Bloodstock Services Limited | Arts & recreation | 2013 |
| Erika Properties Ltd | Real estate | 2022 |
| Erom Homes Ltd | Real estate | 2021 |
| Erom Solutions Ltd | Information & communication | 2023 |
| ERW PUB Co Ltd | Hospitality | 2020 |
| Escaway Limited | Professional & scientific | 1971 |
| ESI UK Limited | Administrative & support | 2001 |
| Esox Homes Ltd | Construction | 2015 |
| Espinar Equine Associates Limited | Professional & scientific | 2018 |
| Essense Beauty Limited | Administrative & support | 2010 |
| Essential Wealth Advice Limited | Professional & scientific | 2013 |
| Essential Wealth Management and Advice Limited | Professional & scientific | 2000 |
| Essential Wealth Management Limited | Professional & scientific | 2013 |
| Estlea Creative Limited | Other services | 2021 |
| Ethorix Limited | Wholesale & retail | 2025 |
| Eton Blue Racing Limited | Professional & scientific | 2013 |
| ETS Events Ltd | Arts & recreation | 2020 |
| Euls Ltd | Construction | 2013 |
| Eunice IT Services Limited | Information & communication | 2021 |
| Eurasian Energy Ventures Limited | Professional & scientific | 2008 |
| Eurocarb Limited | Wholesale & retail | 2000 |
| European Embalming Products Company Limited | Wholesale & retail | 2009 |
| European Lamp Group Limited | Extraterritorial | 1998 |
| European Roll Supplies Ltd | Professional & scientific | 2010 |
| European School of Embalming Skills Limited | Education | 2013 |
| EV Risk Ltd | Information & communication | 2024 |
| EV Risk Ratings Limited | Information & communication | 2019 |
| Evalue Ltd | Information & communication | 2010 |
| Evening Group Holdings Ltd | Financial services | 2025 |
| Evening Investment Group Limited | Financial services | 2022 |
| Evening Studio Ltd. | Information & communication | 2025 |
| Evening UK Investment Limited | Financial services | 2022 |
| Event FX Limited | Arts & recreation | 2009 |
| Eventrex UK Ltd | Arts & recreation | 2016 |
| Evergreen Newbury Ltd | Hospitality | 2020 |
| Evolo Medica Limited | Professional & scientific | 2009 |
| Evolve House and Grounds Limited | Construction | 2013 |
| Ewemove (Newbury) Limited | Real estate | 2015 |
| EWI Tutoring Limited | Education | 2021 |
| Exacta Analytics Ltd | Professional & scientific | 2026 |
| Excel Executive Chauffeurs Limited | Transport & logistics | 2005 |
| Excelya Clinical Research Limited | Professional & scientific | 2021 |
| Excelya UK Limited | Professional & scientific | 2004 |
| Exceptional Motion Pictures Ltd | Information & communication | 2019 |
| Execbiz Limited | Professional & scientific | 2020 |
| Executives on Demand Ltd. | Administrative & support | 1994 |
| Exit Timeshare NOW Limited | Administrative & support | 2020 |
| Exony Limited | Information & communication | 1999 |
| Experience Awaits Ltd | Administrative & support | 2024 |
| Experienced Associates Limited | Professional & scientific | 2024 |
| Experimental Films Ltd | Information & communication | 2019 |
| Export Solutions (International) Limited | Wholesale & retail | 2000 |
| Express DK Ltd | Transport & logistics | 2025 |
| Express Global Education Limited | Education | 2015 |
| Express Publishing Limited | Information & communication | 1998 |
| Expressive Films Ltd | Information & communication | 2019 |
| Exterior Lighting Solutions (UK) Ltd | Extraterritorial | 2005 |
| Exterior Lighting Solutions Holding Ltd | Financial services | 2020 |
| Extremis Limited | Professional & scientific | 2011 |
| EZO17 Ltd | Hospitality | 2024 |
| F.A. Moss Ltd | Professional & scientific | 2005 |
| F.R.X. Limited | Manufacturing | 2000 |
| F1 Impact Limited | Professional & scientific | 2011 |
| F4J UK Ltd | Other services | 2020 |
| Facility and Property Resource Limited | Professional & scientific | 2004 |
| Factor X Energy Ltd | Professional & scientific | 2023 |
| Faded Urban Grooming Lounge Ltd | Other services | 2018 |
| Fair Salinia Limited | Agriculture & fishing | 1986 |
| Fairhurst Estates Properties Limited | Real estate | 1985 |
| Fairview Cottages Limited | Households | 2004 |
| Fairview Thoroughbreds Limited | Arts & recreation | 2019 |
| Faithfull Consulting Limited | Professional & scientific | 2016 |