| Darter Development Limited | Construction | 2025 |
| DAS Services Limited | Other services | 2024 |
| Databench MR Ltd | Information & communication | 2017 |
| Datako Ltd | Professional & scientific | 2022 |
| Dave Ronin Ltd | Extraterritorial | 2014 |
| Daveco Exports Limited | Real estate | 1979 |
| Davies Bookkeeping Limited | Professional & scientific | 2011 |
| DAW Advisory Services Limited | Other services | 2014 |
| Dawoo Design Limited | Professional & scientific | 2015 |
| Dawoo Development Ltd | Real estate | 2023 |
| Day and Nite Services Ltd | Health & social care | 2011 |
| Daysmore Limited | Professional & scientific | 2022 |
| DBL MAX Holdings Limited | Financial services | 2024 |
| DD Mall Limited | Wholesale & retail | 2022 |
| Ddll Global Ltd | Financial services | 2026 |
| Ddta Ltd | Professional & scientific | 2018 |
| DE Luca Vian Importers Limited | Wholesale & retail | 2011 |
| De-Lalji Properties Ltd | Real estate | 2025 |
| Deag Consulting Group Ltd | Wholesale & retail | 2018 |
| Dean Whiting Photography Limited | Professional & scientific | 2012 |
| Deanhill Court Freehold 1 Limited | Real estate | 2014 |
| Decisive Media Group Limited | Professional & scientific | 2009 |
| Decisive Media Innovations Limited | Information & communication | 2009 |
| Decisive Media Limited | Information & communication | 2001 |
| Declarative Solutions Limited | Information & communication | 2014 |
| Decodhr Limited | Professional & scientific | 2024 |
| Decopark UK Ltd | Construction | 2014 |
| Deep Nest Ltd | Construction | 2023 |
| Deepa Panch Limited | Health & social care | 2015 |
| Deer Park Freehold Limited | Households | 1999 |
| Deevorah Limited | Wholesale & retail | 2025 |
| DEL Giudice Ltd | Health & social care | 2023 |
| Delfix Limited | Information & communication | 2008 |
| Delight Hair Studio Ltd | Other services | 2021 |
| Delphus Clinic & Space Ltd | Professional & scientific | 2021 |
| Delta Profloor UK Ltd | Construction | 2019 |
| Demarjo Ltd | Information & communication | 2016 |
| Demir Islington Limited | Other services | 2019 |
| Demolition Management Consulting Ltd | Professional & scientific | 2025 |
| Denarii Capital Limited | Financial services | 2016 |
| Denmark Avenue RTM Company Limited | Households | 2006 |
| Desveen's Bakery&Cafe Ltd | Hospitality | 2025 |
| Development 7 Ltd | Construction | 2018 |
| Development 8 Ltd | Construction | 2021 |
| Development 9 Ltd | Construction | 2021 |
| Development.Net Limited | Information & communication | 2009 |
| Devilliers Holdings Ltd | Financial services | 2021 |
| Devyn Investment Services Limited | Professional & scientific | 2005 |
| Dexo Ltd | Energy | 2026 |
| Dgardens Group Ltd | Other services | 2019 |
| Dhelve Limited | Real estate | 2013 |
| Diamond J Limited | Manufacturing | 2024 |
| Dias Associates Ltd | Real estate | 2012 |
| Dift Services Limited | Professional & scientific | 2005 |
| Digimedica Ltd | Information & communication | 2025 |
| Digital Content Labs Ltd | Professional & scientific | 2024 |
| Dikora Ltd | Manufacturing | 2025 |
| DIN Bros Construction Ltd | Construction | 2016 |
| DIN Bros Group Ltd | Construction | 2016 |
| DIN Brothers Construction Ltd | Construction | 2016 |
| Dingov Limited | Construction | 2012 |
| District Group Services Ltd | Construction | 2023 |
| Django Consulting Ltd | Information & communication | 2021 |
| DJR Coaching Ltd | Arts & recreation | 2021 |
| DK Entertainment Ltd | Transport & logistics | 2020 |
| DLC Purified Water Limited | Wholesale & retail | 2022 |
| DNC Innovation Ltd | Wholesale & retail | 2015 |
| DNL Properties London Ltd | Real estate | 2026 |
| Doan Real Estate Ltd | Real estate | 2024 |
| Dodo London Ltd | Wholesale & retail | 2018 |
| Doinj UK Ltd | Hospitality | 2023 |
| Dolago Associates Ltd | Professional & scientific | 2023 |
| Dongeruzi Legacy Ltd | Health & social care | 2019 |
| Donnamu Ltd | Hospitality | 2022 |
| Dooboo Yiyagi Limited | Manufacturing | 2009 |
| Double B Associates Ltd | Professional & scientific | 2025 |
| Double H Cleaning Limited | Households | 2014 |
| Double Rainbows 2024 Ltd | Real estate | 2024 |
| Doum C&A Ltd | Administrative & support | 2025 |
| Down in the Woods Limited | Administrative & support | 2012 |
| DR Al-Abdullah Ltd | Health & social care | 2024 |
| DR Dharanish Javaregowda Limited | Health & social care | 2013 |
| DR LM West Ltd | Health & social care | 2019 |
| DR. a Paul Limited | Health & social care | 2011 |
| DR. a. Kanagasivam Ltd | Health & social care | 2025 |
| Drakes Services Ltd | Construction | 2019 |
| Draw Talent Ltd | Professional & scientific | 2011 |
| Drbrito Solutions Ltd | Construction | 2025 |
| Dream Enterprise UK Ltd | Hospitality | 2023 |
| Dream House Extension Ltd | Construction | 2018 |
| Dreamland Trading Limited | Professional & scientific | 2017 |
| Dreamnara Ltd | Hospitality | 2016 |
| Driftlife Ltd | Extraterritorial | 2020 |
| Drivewise Dealership Ltd | Wholesale & retail | 2024 |
| Drum Resourcing Limited | Professional & scientific | 2011 |
| Drwd Ltd | Health & social care | 2025 |
| DS Byron Ltd | Real estate | 2021 |
| Dssc Europe Limited | Information & communication | 2010 |
| Duagr Limited | Real estate | 2013 |
| Dual Sport Europe Ltd | Wholesale & retail | 2023 |