| Bruce Delfosse Interpreter Training Limited | Professional & scientific | 2018 |
| Bruno Lifts Limited | Wholesale & retail | 2008 |
| Bryan CT Limited | Households | 2025 |
| Burtons Kitchen & Events Limited | Hospitality | 2023 |
| Business & Leadership Excellence Ltd | Professional & scientific | 2026 |
| BW Consultancy and Leadership Ltd | Professional & scientific | 2020 |
| Calderstones Group Limited | Other services | 2025 |
| Campbell Holdings Limited | Real estate | 2001 |
| Capacity Assessment Solutions Ltd | Health & social care | 2025 |
| Castle JET Wash Ltd | Administrative & support | 2021 |
| Catherine Smith Associates Ltd | Professional & scientific | 2019 |
| Cavendish Court (Neston) Management Limited | Households | 2016 |
| CBG Properties Limited | Real estate | 2016 |
| CDA PS Ltd | Construction | 2017 |
| CDS Chefs Ltd | Hospitality | 2026 |
| Ceecee’S Ltd | Hospitality | 2020 |
| Centre D'Accueil Europeen Trust Limited | Education | 1984 |
| Chapel Construction Wirral Limited | Construction | 2007 |
| Chapter X Ltd | Professional & scientific | 2023 |
| Charles Antony Homes Ltd | Construction | 2021 |
| Charles PC Taylor Limited | Administrative & support | 2025 |
| Chat Noir Productions Ltd | Information & communication | 2003 |
| Cheftom Limited | Hospitality | 2016 |
| Cherry Inheritance LLP | | 2024 |
| Cheshire Airbrake Ltd | Manufacturing | 2016 |
| Cheshire Spas & Pools Limited | Construction | 1996 |
| Cheshire Spas & Swimming Pools Ltd | Extraterritorial | 2008 |
| Cheshire Wedding Entertainment Limited | Arts & recreation | 2024 |
| Chester Consultancy Services Ltd | Professional & scientific | 2019 |
| Chevalier Aviation Limited | Other services | 2015 |
| Childs Fabrication Ltd | Construction | 2016 |
| Church Farm Enterprises Limited | Wholesale & retail | 2011 |
| CJ Founds Associates Ltd | Professional & scientific | 2016 |
| CJS Properties (Wirral) Limited | Real estate | 2015 |
| CJT Installations Ltd | Construction | 2011 |
| Clarity Investment Capital Ltd | Information & communication | 2026 |
| Clarstra Ltd | Administrative & support | 2025 |
| Clasx Ltd | Wholesale & retail | 2020 |
| Cleandesign Ltd | Wholesale & retail | 2020 |
| Clear Commercial Clean Ltd | Administrative & support | 2025 |
| Clear Escapes Limited | Administrative & support | 2021 |
| Cliden Consultants Limited | Professional & scientific | 2008 |
| Clth Hub CIC | Education | 2024 |
| Clydesdale Timber Products Limited | Manufacturing | 1997 |
| COL Studio Limited | Wholesale & retail | 2021 |
| Colour Coordinate BP Limited | Administrative & support | 2009 |
| Concept Carpet Warehouse Limited | Wholesale & retail | 2003 |
| Consolidated Irish Whiskey Limited | Manufacturing | 2024 |
| Constables Cheshire Limited | Real estate | 2019 |
| Constables Holdings Limited | Financial services | 2023 |
| Contigal Limited | Health & social care | 2020 |
| Cordata Financial Solutions Ltd | Professional & scientific | 2013 |
| Corveth Commerce Ltd | Wholesale & retail | 2026 |
| Countryside Conservation Ltd | Administrative & support | 2003 |
| County Inns Ltd | Hospitality | 2008 |
| Cover Story Weddings & Events Ltd | Administrative & support | 2023 |
| COZ Trans Ltd | Transport & logistics | 2018 |
| CPH Management & NED Ltd | Professional & scientific | 2023 |
| Cranston Inspection Limited | Professional & scientific | 2010 |
| Creatineade Ltd | Wholesale & retail | 2022 |
| Creativeaf Ltd | Information & communication | 2020 |
| Ctech Europe Ltd | Manufacturing | 1996 |
| CWT Building Consultants Ltd | Construction | 2022 |
| Cwtch Hamilton Projects Ltd | Real estate | 2018 |
| D B R Engineering Solutions Limited | Professional & scientific | 2007 |
| D Owen Property Ltd | Real estate | 2022 |
| D Shaw Joinery Limited | Construction | 2016 |
| D&R Property Holdings Ltd | Real estate | 2025 |
| D13 Inc Ltd | Financial services | 2022 |
| Daniru Ltd | Agriculture & fishing | 2023 |
| Darlington Property Ltd | Real estate | 2011 |
| Datomic Services Limited | Water & waste | 2015 |
| David Chin Audio Ltd | Arts & recreation | 2024 |
| David F Ellis Ltd | Professional & scientific | 2017 |
| David I Roberts (Engineering Services) Limited | Construction | 1998 |
| Davies Cabinetry Limited | Professional & scientific | 2021 |
| Davies Motorsport Ltd | Wholesale & retail | 2018 |
| Dawstone Construction Ltd | Construction | 2024 |
| DBB Ltd | Transport & logistics | 2026 |
| Deepclean NW Ltd | Administrative & support | 2022 |
| Denna Group Ltd | Wholesale & retail | 2011 |
| Dermasense Limited | Professional & scientific | 2022 |
| DG Construction Wirral Limited | Construction | 2020 |
| Dgck Ltd | Information & communication | 2010 |
| DIA Loirez Ltd | Wholesale & retail | 2024 |
| Digitel Business Communications Limited | Information & communication | 1998 |
| DJ Small & Sons Builders Ltd | Construction | 2022 |
| DMA Services U.K. Ltd | Administrative & support | 2025 |
| DMS Business Consultancy Limited | Professional & scientific | 2020 |
| Dolpharma Consult Ltd | Professional & scientific | 2012 |
| Doughpamine Events Company Ltd | Extraterritorial | 2023 |
| DP Build Wirral Ltd | Construction | 2025 |
| Dragonfly Renovations Limited | Construction | 2020 |
| Drew Financial Planning Ltd | Financial services | 2022 |
| Drift Deliveries Ltd | Transport & logistics | 2025 |
| DT Mountain Guiding Ltd | Administrative & support | 2023 |
| Dunstan Legal Limited | Professional & scientific | 2022 |
| DW Computer Services NW Ltd | Information & communication | 2020 |
| Dynamize Productions Limited | Administrative & support | 2021 |
| E 4 G Limited | Professional & scientific | 2015 |