| Demystify Digital Limited | Information & communication | 2022 |
| Deni Trading UK Ltd | Construction | 2018 |
| Desi Fusion Nelson Limited | Hospitality | 2025 |
| Desi Scran Limited | Hospitality | 2026 |
| Desi Treats Limited | Wholesale & retail | 2025 |
| Design Scape Ltd | Administrative & support | 2023 |
| Devln Ltd | Information & communication | 2026 |
| Dewar French Polishers Limited | Other services | 2011 |
| Dexdyne Limited | Manufacturing | 1991 |
| Dezyre Ltd | Wholesale & retail | 2011 |
| DFK Holdings Limited | Professional & scientific | 2013 |
| DHS Transport Ltd | Transport & logistics | 2021 |
| Diamond Care (Nelson) Limited | Health & social care | 2023 |
| Diamond Cars Pendle Limited | Wholesale & retail | 2025 |
| Diamond Fresh Cleaning Ltd | Construction | 2025 |
| Diamond Homes Europe Ltd | Real estate | 2016 |
| Diamondback Express Ltd | Transport & logistics | 2025 |
| DIG & Play Landscape Services Limited | Construction | 2020 |
| Digital Picks Ltd | Wholesale & retail | 2024 |
| Digitery Business Centre Ltd | Professional & scientific | 2023 |
| Dignity Living Ltd | Health & social care | 2023 |
| Dimarian Ltd | Real estate | 1995 |
| Dinu Transport Ltd | Transport & logistics | 2025 |
| Dionight Group Limited | Hospitality | 2017 |
| Direct Real Estate Ltd | Real estate | 2023 |
| Direct Wallpapers (Retail) Limited | Wholesale & retail | 2007 |
| Discount Carpet Tiles Ltd | Construction | 2004 |
| Diversicare Limited | Health & social care | 2017 |
| Diversicare Supported Living Limited | Public administration | 2024 |
| Dixeychicken&Deserts Limited | Hospitality | 2023 |
| Dixy Pendle Ltd | Hospitality | 2025 |
| DJM Consulting Limited | Professional & scientific | 2022 |
| DK Properties (NW) Ltd | Real estate | 2022 |
| Dlonge Limited | Financial services | 2018 |
| DM Publishing Ltd | Information & communication | 2021 |
| DN Law Limited | Professional & scientific | 2012 |
| DOC4U Ltd | Health & social care | 2017 |
| Dockray Security Group Ltd | Administrative & support | 2026 |
| Dodge the Draft Ltd | Information & communication | 2013 |
| DOI Property Service Limited | Real estate | 2019 |
| Dolce Fleur Ltd | Wholesale & retail | 2026 |
| Dominion Woodworking Machinery Ltd | Professional & scientific | 2003 |
| Doncaster Gateway Ltd | Transport & logistics | 2025 |
| Dorchester Interiors Limited | Wholesale & retail | 2019 |
| Dosanjh Developments Limited | Health & social care | 2002 |
| DOT Rewards Ltd | Administrative & support | 2023 |
| DP Structures Ltd | Manufacturing | 2006 |
| Dpke Limited | Professional & scientific | 2023 |
| DR H T Manzur Ltd | Professional & scientific | 2014 |
| DR MHM Ltd | Health & social care | 2014 |
| Drcwelding Ltd | Professional & scientific | 2025 |
| Dream Interiors RV Ltd | Professional & scientific | 2024 |
| Dream Mart Limited | Wholesale & retail | 2026 |
| Dreamhub Beds & Furniture Ltd | Manufacturing | 2024 |
| Dreamy Delights Ltd | Wholesale & retail | 2025 |
| Driveaze Ltd | Education | 2025 |
| Drivecraft Ltd | Construction | 2020 |
| Driveline Cars & Vans Ltd | Wholesale & retail | 2026 |
| Drivelinecarsandvansltd Ltd | Wholesale & retail | 2026 |
| Driven Wealth Limited | Financial services | 2013 |
| DS Brothers Contractors Limited | Construction | 2008 |
| DUA Fatima Ltd | Real estate | 2024 |
| Dubai Shawarma Nelson Limited | Hospitality | 2026 |
| Durani Foods Lancashire Limited | Wholesale & retail | 2023 |
| Dustbegone Cleaning Services Limited | Administrative & support | 2025 |
| Dustix Ltd | Wholesale & retail | 2024 |
| Dutch Decor Ltd | Construction | 2025 |
| Dvcr Bolton Ltd | Health & social care | 2025 |
| Dvcr Franchising Limited | Health & social care | 2025 |
| DW Motor Sales Ltd | Wholesale & retail | 2022 |
| Dy-Tech Ltd | Manufacturing | 2004 |
| Dymond Ashworth Limited | Professional & scientific | 2002 |
| Dynamic Recruitment Ltd | Administrative & support | 2019 |
| E & D Hire Ltd | Administrative & support | 2021 |
| E Home Basics Ltd | Wholesale & retail | 2014 |
| E Salon Ltd | Other services | 2026 |
| E- REG Coatings Limited | Manufacturing | 1992 |
| E.D.T. Metal Works Ltd | Manufacturing | 2015 |
| E.M Upholstery Limited | Manufacturing | 2025 |
| E.T Upholstery Ltd | Manufacturing | 2022 |
| Eagle Gate Holdings Limited | Financial services | 2026 |
| Eamaar Properties Limited | Real estate | 2025 |
| EAN Letting Ltd | Real estate | 2024 |
| Earl HAU Limited | Wholesale & retail | 2020 |
| Easier to Limited | Wholesale & retail | 2012 |
| East Lancashire Pest Control Limited | Administrative & support | 2013 |
| East Lancashire Regeneration Ltd | Real estate | 2012 |
| Eastham & Partington Ltd | Construction | 2011 |
| Easy Leaf Distribution Ltd | Professional & scientific | 2017 |
| Easy Space Creative Building Components Limited | Manufacturing | 2015 |
| Eaton Adams Legal Limited | Professional & scientific | 2018 |
| Ebiz Designs & Web Solutions Ltd | Information & communication | 2022 |
| Ebor Way Property Consulting Limited | Real estate | 2016 |
| Echobloom Limited | Wholesale & retail | 2023 |
| Eco 365 Ltd | Other services | 2020 |
| Eco Energy Efficient Services Ltd | Construction | 2024 |
| Eco Renewables NW Ltd | Construction | 2025 |
| Eco-Logic Facilities Ltd | Other services | 2025 |
| Ecoworld Limited | Construction | 2024 |
| Eddies Bakers Ltd | Manufacturing | 2026 |