| Coach House Whitchurch Ltd | Administrative & support | 2024 |
| Coax Creative Limited | Information & communication | 2018 |
| Coco & Gizmo Ltd | Wholesale & retail | 2017 |
| Coco Beach Nail Bar Ltd | Other services | 2024 |
| Cocoa Gardens Management Limited | Hospitality | 1995 |
| Coderra Ltd. | Information & communication | 2012 |
| Coffee & Tea Lounge Limited | Hospitality | 2026 |
| COG 7 Training and Conference Centre | | 2009 |
| Coher Ltd | Professional & scientific | 2024 |
| Coherent Solutions Limited | Information & communication | 2008 |
| Colclough Infra Consulting Ltd | Construction | 2026 |
| Coleridge Court (Crewe) Limited | Real estate | 2016 |
| Collaborative Conveyancing Limited | Professional & scientific | 2021 |
| Collings Construction Management Limited | Professional & scientific | 2010 |
| Collings Letting Services Limited | Real estate | 2017 |
| Colour Plastic Cards Limited | Manufacturing | 2006 |
| Commercial Funding (UK) Ltd | Financial services | 2011 |
| Commercial Vehicle Services Limited | Wholesale & retail | 2003 |
| Communique-Online Limited | Professional & scientific | 2003 |
| Company Jinks Ltd | Arts & recreation | 2019 |
| Compass Design Studio Limited | Professional & scientific | 2021 |
| Concrete Floors Ltd | Professional & scientific | 2018 |
| Concrete Technology Limited | Wholesale & retail | 2006 |
| Confidence Sales Training Ltd | Other services | 2025 |
| Conker Living Limited | Manufacturing | 2017 |
| Connect Design Solutions Limited | Professional & scientific | 2025 |
| Connect Education Solutions Ltd | Education | 2018 |
| Connect Training Solutions Ltd | Education | 2018 |
| Consols Oils Limited | Wholesale & retail | 1993 |
| Constructo 7 Limited | Water & waste | 2024 |
| Constructo Fleet Hire Limited | Administrative & support | 2024 |
| Consulcode Limited | Information & communication | 2018 |
| Consulting One Ltd | Households | 2024 |
| Cooks PIT Management Company Limited | Households | 2021 |
| Coole Acres Fishery & Leisure Park Ltd | Hospitality | 2023 |
| Cooper Moulton Estates Ltd | Wholesale & retail | 2025 |
| Coordinate IT Limited | Information & communication | 2008 |
| Cope Prees Limited | Agriculture & fishing | 2018 |
| Copper OWL Limited | Wholesale & retail | 2023 |
| Coral Reef Takeaway Ltd | Hospitality | 2020 |
| Corchange Limited | Administrative & support | 2014 |
| Corefitnessuk Limited | Professional & scientific | 2024 |
| Corner House (Granville) Ltd | Hospitality | 1995 |
| Cornes & Co Ltd | Agriculture & fishing | 2020 |
| Coronation Gardens (Management Company) Limited | Real estate | 1998 |
| Coronet Green Management Limited | Real estate | 2017 |
| Corporate Wellbeing Solutions Ltd | Administrative & support | 2022 |
| Cosycornerhouses Limited | Real estate | 2025 |
| Cotton Wolf Communications Ltd | Professional & scientific | 2024 |
| County Bedrooms Limited | Construction | 2012 |
| Courtline LLP | | 2013 |
| Covent Garden Trading Ltd | Manufacturing | 2020 |
| COX Rail Consulting Limited | Professional & scientific | 2017 |
| CPW Limited | Professional & scientific | 2019 |
| Creamery Industrial Estate Maintenance Company Limited | Administrative & support | 1990 |
| Creatif Digital Limited | Information & communication | 2022 |
| Creative Capital Solutions Ltd | Financial services | 2018 |
| Crewe & Nantwich Funeral Services Limited | Extraterritorial | 2017 |
| Crewe & Nantwich Rugby Union Football Club Limited | Arts & recreation | 2016 |
| Crewe and Nantwich GAS Training Centre Limited | Administrative & support | 2006 |
| Crewe Arms Motor Co Limited (the) | Other services | 1927 |
| Crewe Business Park Management Limited | Real estate | 2008 |
| Crewe Engineering Group Holdings Limited | Professional & scientific | 2009 |
| Crewe Precision Engineering Limited | Manufacturing | 1984 |
| Crewe Town Football Club CIC | Arts & recreation | 2021 |
| Crewe Trade Park Limited | Real estate | 2024 |
| Crighton Marketing Ltd | Professional & scientific | 2017 |
| Crimsonbase IT Limited | Information & communication | 2011 |
| Criona Ltd | Professional & scientific | 2024 |
| Croft Home Developments Limited | Real estate | 2006 |
| Crown Hotel (Nantwich) Ltd | Hospitality | 2013 |
| Crowngrand Ltd | Information & communication | 2025 |
| Crownhall Limited | Real estate | 1983 |
| Crumleigh Heath Limited | Agriculture & fishing | 2005 |
| Crystal Clean South Cheshire Limited | Other services | 2015 |
| Crystal Management Holdings Limited | Financial services | 2018 |
| CS Management Solutions Limited | Professional & scientific | 2009 |
| CT Education and Skills Consultants Ltd | Education | 2018 |
| CTM Agricultural Contractors Limited | Professional & scientific | 2018 |
| CTP Driver Training Ltd | Education | 2025 |
| Cuddlywoof Ltd | Administrative & support | 2019 |
| Cummings Consulting Ltd | Information & communication | 2024 |
| Cureton Dewhurst Limited | Professional & scientific | 2010 |
| Curtainsider Engineering Limited | Wholesale & retail | 2006 |
| Custom Maintenance Services Limited | Manufacturing | 2021 |
| CW5 Gadgets Limited | Wholesale & retail | 2012 |
| Cyberco Ltd | Information & communication | 1996 |
| D & B Remediation Limited | Water & waste | 2011 |
| D & D Tyres Limited | Wholesale & retail | 1980 |
| D 7 to Trent Locksmith Ltd | Professional & scientific | 2022 |
| D B Groundwork Services Limited | Construction | 2010 |
| D Hargreaves Ltd | Construction | 2019 |
| D Harris Farm Supplies Limited | Agriculture & fishing | 2011 |
| D I Pickering Limited | Wholesale & retail | 2023 |
| D J Lowe and Partners Limited | Agriculture & fishing | 2008 |
| D T Fitness Limited | Arts & recreation | 2016 |
| D.Archer Homes Limited | Real estate | 2018 |
| D.H.Grocott Limited | Professional & scientific | 1963 |
| D.K. Printmasters Limited | Manufacturing | 2003 |
| D19GAL Ltd | Professional & scientific | 2015 |