| Deakin FX Limited | Financial services | 2025 |
| Delameer Limited | Real estate | 2013 |
| Delishous Ltd | Hospitality | 2021 |
| DEM Motorcycles Ltd | Wholesale & retail | 2025 |
| Demi Mccreadie Aesthetics Limited | Other services | 2019 |
| Denby Supplies Ltd | Manufacturing | 2017 |
| Dent Smart PDR Limited | Wholesale & retail | 2012 |
| Derelict Arts CIC | Arts & recreation | 2022 |
| Desert Hearts Limited | Extraterritorial | 2019 |
| Desiccant Dryair Systems Limited | Extraterritorial | 2006 |
| Deter IT Ltd | Administrative & support | 2023 |
| Development Trading Co., Ltd | Administrative & support | 2021 |
| Devonshire Court Management Company (Lancaster) Limited | Hospitality | 2007 |
| Dexland Limited | Hospitality | 1999 |
| DGC Paving Limited | Construction | 2020 |
| Dickie Developments (Garstang) Limited | Construction | 2026 |
| Dickie Developments (HB) Limited | Construction | 2026 |
| Dickson GAS Services Ltd | Construction | 2016 |
| Diplos Pizza Ltd | Wholesale & retail | 2022 |
| Direct to Beauty Ltd | Information & communication | 2023 |
| Diviny Livery Limited | Agriculture & fishing | 2008 |
| Dixon Heath Electrical Ltd | Construction | 2016 |
| DJC Paving Limited | Construction | 2012 |
| DJR Electrical Contractors Ltd | Construction | 2024 |
| DL Nails 68 Ltd | Other services | 2026 |
| Dmam Lancashire Limited | Financial services | 2024 |
| Dmct Investments Ltd | Financial services | 2026 |
| Dobson Marine Services Ltd | Manufacturing | 2020 |
| Donnelly Wood Estates Ltd | Real estate | 2026 |
| Dorysk Group Ltd | Administrative & support | 2025 |
| DR Contracting North West Limited | Construction | 2024 |
| Dragonfly Healing Limited | Health & social care | 2013 |
| Driveline and Hydraulic Engineering Limited | Manufacturing | 2005 |
| Driveline Properties Limited | Real estate | 2021 |
| DSP Building Company Limited | Construction | 2019 |
| DST Group Limited | Manufacturing | 1993 |
| DTM Engineering Limited | Manufacturing | 2017 |
| Dudman Tidbury HR Limited | Administrative & support | 2022 |
| Duffys PUB Hub Ltd | Hospitality | 2024 |
| Dusktodawn Ltd | Transport & logistics | 2024 |
| DW Builders Limited | Administrative & support | 2022 |
| E D K Truckage Ltd | Transport & logistics | 2015 |
| E Kolodziejski & Sons Investments Ltd | Real estate | 2025 |
| E.T.I.S Limited | Construction | 2016 |
| Eagle Ideas Ltd | Hospitality | 2020 |
| Ear-Buddy! Limited | Information & communication | 2022 |
| Earl Bar Company Ltd | Hospitality | 2022 |
| Eclipse Events Hire Morcambe Ltd | Administrative & support | 2026 |
| Eco by Design Limited | Construction | 2023 |
| Eco Clean Morecambe Ltd | Administrative & support | 2026 |
| Eco Cork Render Ltd | Construction | 2026 |
| Eco Renewable Sparks Ltd | Construction | 2023 |
| Ecoglobal Omniverse Ltd | Wholesale & retail | 2024 |
| Ecopac Green Energy Limited | Construction | 2010 |
| ECS Cash and Carry Ltd | Wholesale & retail | 2019 |
| Ecycle Goods | | 2010 |
| Eddie Wood Haulage Ltd | Transport & logistics | 2016 |
| Eden Autos (North West) Limited | Wholesale & retail | 2022 |
| Eden Bay Property Ltd | Construction | 2025 |
| Eden Breaks (Morecambe) Ltd | Hospitality | 2025 |
| Eden Cleaning Company Limited | Administrative & support | 2023 |
| Eden Escapes Morecambe Limited | Real estate | 2020 |
| Eden Home Help Ltd | Administrative & support | 2023 |
| Eden North Limited | Real estate | 2023 |
| Eden North Metal Recycling(Morecambe) Ltd | Wholesale & retail | 2023 |
| Eden Stay Ltd | Hospitality | 2023 |
| Eden View Retreat Ltd | Hospitality | 2023 |
| Eden-Nw Utilities Ltd | Construction | 2025 |
| Education Smart Limited | Education | 2011 |
| Eglin Kitchens Limited | Construction | 2024 |
| EJH Racing Ltd | Arts & recreation | 2024 |
| ELA & Tomi Limited | Wholesale & retail | 2010 |
| Elanis Ltd | Professional & scientific | 2026 |
| Elder Property Holdings Ltd | Real estate | 2024 |
| Electric Piñata Limited | Manufacturing | 2020 |
| Elite Escapes NW Ltd | Transport & logistics | 2023 |
| Elite Escapes Properties Ltd | Real estate | 2025 |
| Elite Scaffolds (NW) Ltd | Construction | 2021 |
| Elite Upvc Limited | Construction | 2017 |
| Elivie Estates Limited | Real estate | 2025 |
| Elixir Gym Ltd | Arts & recreation | 2024 |
| Elle Kitchen Ltd | Hospitality | 2025 |
| Ellison AC Limited | Wholesale & retail | 2007 |
| Ellison Engineering Services (UK) Limited | Extraterritorial | 2017 |
| Ellison Engineering Services (UK) Manufacturing Ltd | Manufacturing | 2026 |
| Ellison Global Air Solutions Ltd | Extraterritorial | 2023 |
| Ellys Extra Care Limited | Hospitality | 1989 |
| Elmsfield Consulting Limited | Professional & scientific | 2009 |
| Elmsfield Holdings Limited | Professional & scientific | 2008 |
| EMC Electrical Services Northwest Limited | Construction | 2021 |
| Empire Flooring Services Limited | Wholesale & retail | 2006 |
| Employer Solutions Limited | Professional & scientific | 2003 |
| Empowered Aspects Ltd | Manufacturing | 2023 |
| Empress Court (Marine Road East) Flat Management Company Limited | Real estate | 2002 |
| Enable Support Group C.I.C. | Health & social care | 2023 |
| Engineering Solutions Worldwide Limited | Extraterritorial | 2010 |
| Enhance Laser & Skin Clinic Ltd | Other services | 2023 |
| Enveloped Design Solutions Limited | Professional & scientific | 2015 |
| Enviro Metals Lancaster Ltd | Water & waste | 2012 |
| Envirotech Recycling UK Ltd | Water & waste | 2016 |