| SB Driverhire Ltd | Transport & logistics | 2013 |
| SBR BSL Community Interpreting Ltd | Professional & scientific | 2026 |
| Scaredy Dog Limited | Wholesale & retail | 2023 |
| Scargill Farm Limited | Agriculture & fishing | 2023 |
| Scomadi Scooter Centre Limited | Wholesale & retail | 2015 |
| Scotson Construction Limited | Construction | 2002 |
| SD Site Services Limited | Construction | 2023 |
| Seaborn Stores Ltd | Wholesale & retail | 2022 |
| Seacrest Hotel Limited | Hospitality | 2006 |
| Seaside Market Ltd | Wholesale & retail | 2025 |
| Seaview Chinese Takeaway Limited | Hospitality | 2008 |
| Secmore Ltd | Administrative & support | 2024 |
| Securelink Networks Ltd | Transport & logistics | 2023 |
| Securitec Limited | Administrative & support | 2000 |
| Security Services Westcoast Ltd | Administrative & support | 2018 |
| Sedgwick Enterprises Limited | Information & communication | 2023 |
| Seniorecaregroup Ltd | Health & social care | 2025 |
| Serendipity Accommodations Ltd | Hospitality | 2023 |
| Seven Maintenance Ltd | Administrative & support | 2022 |
| Seven Stars Barbershop Ltd | Other services | 2025 |
| SG MAN & Van Ltd | Transport & logistics | 2021 |
| SGR Holdings Ltd | Financial services | 2022 |
| SGR Properties & Letting Ltd | Real estate | 2019 |
| SGR Property Services Ltd | Administrative & support | 2022 |
| Shane Dale Plastering Limited | Construction | 2019 |
| Shanley Air Conditioning Services Limited | Construction | 2000 |
| SHC Sales Ltd | Wholesale & retail | 2018 |
| Shearsby Services Limited | Administrative & support | 2013 |
| Shengming Limited | Hospitality | 2026 |
| Shengs (Heysham) Limited | Hospitality | 2014 |
| Shermaynes Engineering Limited | Manufacturing | 1996 |
| Shijanan Ltd | Wholesale & retail | 2017 |
| Shijany Ltd | Real estate | 2013 |
| Shimcup Ltd | Wholesale & retail | 2022 |
| Shirwin Limited | Administrative & support | 2015 |
| Shore and Meadow Holiday Lets Ltd | Hospitality | 2026 |
| Shore Thing Bar Limited | Hospitality | 2023 |
| Shorehost Ltd | Real estate | 2024 |
| Shoreline, Health in Movement CIC | Other services | 2023 |
| Shorrocks Building Works Limited | Construction | 2014 |
| SHT Transport Ltd | Transport & logistics | 2018 |
| Signature Design & Build Limited | Construction | 2013 |
| Silverado Limited | Professional & scientific | 2018 |
| Simnos Consulting Ltd | Information & communication | 2025 |
| Simon James Taylor Limited | Extraterritorial | 2024 |
| Simply Clean (NW) Limited | Administrative & support | 2009 |
| Sing 888 Ltd | Hospitality | 2019 |
| SIP Sportswear Limited | Professional & scientific | 2021 |
| Site Safety Services (NW) Ltd | Professional & scientific | 2024 |
| SJF Bridal Ltd | Wholesale & retail | 2023 |
| SK Building Limited | Construction | 2026 |
| SKF Consultants Limited | Professional & scientific | 2003 |
| Sleep Inn Group Limited | Administrative & support | 2025 |
| Sleep Inn Lancaster Limited | Hospitality | 2014 |
| SM Grab Ltd | Construction | 2023 |
| Smalleys of Lancaster Limited | Wholesale & retail | 2002 |
| Smartsafe Traning Ltd | Health & social care | 2026 |
| Smcards Limited | Wholesale & retail | 2026 |
| SMD Consultants Ltd | Professional & scientific | 2021 |
| Smileyfish Limited | Hospitality | 2023 |
| Smiths Training Limited | Administrative & support | 2018 |
| Smithtronics Ltd | Construction | 2022 |
| Smudge Investments Limited | Real estate | 2024 |
| Snatchems Golden Ball Limited | Hospitality | 2025 |
| SND Save Store Ltd | Wholesale & retail | 2025 |
| SND Store Ltd | Wholesale & retail | 2017 |
| Snowbone Enterprises Limited | Manufacturing | 2012 |
| SNR Developments Ltd | Real estate | 2022 |
| Solarium Luiziana Ltd | Other services | 2016 |
| Sommerville Ltd | Real estate | 2025 |
| South Lakes Reclaimed Slates Ltd | Wholesale & retail | 2024 |
| Southern Housing Solutions Ltd | Real estate | 2024 |
| Southern Integrity Solutions Ltd | Professional & scientific | 2023 |
| Sowden's Spaces Limited | Real estate | 2025 |
| Spartan Driveways NW Ltd | Administrative & support | 2025 |
| Spartan Scaffolding NW Ltd | Construction | 2025 |
| Spdaviesgroundworks Ltd | Extraterritorial | 2023 |
| Special Tuning (UK) Limited | Wholesale & retail | 1986 |
| Special Tuning Racing Ltd | Extraterritorial | 2008 |
| Specialist Care Team Limited | Health & social care | 2010 |
| Spencer Security Services Ltd | Administrative & support | 2025 |
| Spice Room Morecombe Limited | Hospitality | 2025 |
| Spice Room Takeaway (Morecambe) Ltd | Hospitality | 2024 |
| Spirry Holdings Limited | Financial services | 2021 |
| Sport Supplies Ltd | Wholesale & retail | 2021 |
| Sprayed Concrete Solutions Limited | Construction | 2008 |
| Springfield Properties Morecambe Ltd | Real estate | 2002 |
| Spud Runners Ltd | Hospitality | 2026 |
| ST Andrews Bakery Limited | Hospitality | 2020 |
| ST David's Management Company Morecambe Limited | Households | 2002 |
| ST Mary's Cottages Shared Area Management Limited | Real estate | 2018 |
| ST. Winifred's Ltd | Hospitality | 2024 |
| Standens Hire Ltd | Wholesale & retail | 2023 |
| Standens of Lancaster Limited | Hospitality | 2025 |
| Standens of Morecambe Limited | Wholesale & retail | 2025 |
| Stangate Court Residents Association Ltd | Households | 2007 |
| Staunch Blinder Property Limited | Real estate | 2018 |
| Stebbing Contracting Services Limited | Construction | 2016 |
| Steedman Taxis Limited | Transport & logistics | 2003 |
| Stemma Mclean Properties Ltd | Households | 2026 |