| Random Services Limited | Professional & scientific | 1990 |
| RDR Group Ltd | Real estate | 2022 |
| Real Cool Dairy Company Limited | Other services | 2017 |
| Rebel Squirrels Ltd | Construction | 2024 |
| Red Building Services Limited | Construction | 2016 |
| Red Target Ltd | Administrative & support | 2016 |
| Reedevelopments Limited | Construction | 2016 |
| Refit Pembrokeshire Limited | Real estate | 2002 |
| Revo Technologies Ltd | Information & communication | 2024 |
| RH Llewellyn & Sons Ltd | Hospitality | 2025 |
| Rhyal Engineering Limited | Manufacturing | 1998 |
| Rickard Consultancy Limited | Professional & scientific | 2026 |
| Rino Bespoke Tailoring Ltd | Manufacturing | 2020 |
| Ripon Takeaway Ltd | Hospitality | 2023 |
| RK Plumbing & Heating Ltd | Construction | 2010 |
| Rmnr Properties Limited | Real estate | 2024 |
| Roberts Fabrication Limited | Administrative & support | 2017 |
| Rocket Dog Limited | Real estate | 2011 |
| Rosemarket Spring Water Limited | Wholesale & retail | 2003 |
| Roxannes Hair Ltd | Other services | 2019 |
| RP Davis Consulting Limited | Administrative & support | 2010 |
| RTC Convenience Store Ltd | Wholesale & retail | 2019 |
| S & D Electrical Services Pembs Limited | Construction | 2020 |
| S & J.K Enterprises Limited | Wholesale & retail | 2005 |
| S & R Supplies Limited | Wholesale & retail | 2004 |
| S a Scaffolding Services Limited | Construction | 2023 |
| S&A Buddies Limited | Education | 2017 |
| S&D23 Limited | Financial services | 2023 |
| S&P Auto Centre Ltd | Wholesale & retail | 2025 |
| S.J.Sutton Construction Limited | Construction | 2013 |
| S5 North Europe Limited | Transport & logistics | 2008 |
| Safe & Secure Storage Limited | Administrative & support | 2007 |
| Sandrose Barbers Ltd | Other services | 2020 |
| Sandy Haven Caravan Site Limited | Hospitality | 1987 |
| Sarah Anahi Limited | Wholesale & retail | 2025 |
| Satellite Aerial Systems Limited | Information & communication | 2011 |
| SB Construction Consultants Ltd | Construction | 2024 |
| Scale Group Limited | Real estate | 2015 |
| Scent IT Fragrance Ltd | Wholesale & retail | 2025 |
| Scott Walters Limited | Construction | 2017 |
| Sea Sense Surveying Ltd | Professional & scientific | 2018 |
| Selm 1 Wealth Management Ltd | Professional & scientific | 2022 |
| Sentinel Sky Technologies Ltd | Professional & scientific | 2023 |
| Seren Capital Ltd | Wholesale & retail | 2018 |
| Seren David Ltd | Wholesale & retail | 2025 |
| Serenity Design International Limited | Professional & scientific | 2021 |
| SG Safety Services Ltd | Professional & scientific | 2016 |
| SG Vehicle Finance & Consulting Ltd | Wholesale & retail | 2023 |
| Shaik UK Limited | Wholesale & retail | 2013 |
| Shaka Spirits Limited | Wholesale & retail | 2023 |
| Silver Springs Support Limited | Health & social care | 2013 |
| Simmonds-Jones Consulting Ltd | Health & social care | 2021 |
| Simmonds-Jones Holdings Ltd | Real estate | 2026 |
| SJB Travel Limited | Administrative & support | 2024 |
| Skipper Live Limited | Education | 2015 |
| SLA Developments Pembs Ltd | Construction | 2019 |
| SME Growth Partners Limited | Professional & scientific | 2019 |
| Snippers Salon Limited | Other services | 2008 |
| Soas Safety Boats Limited | Other services | 2005 |
| Sorted Supplies Ltd | Wholesale & retail | 2026 |
| South Hook LNG Terminal Company Ltd. | Energy | 2003 |
| South Wales Stainless Ltd | Manufacturing | 2020 |
| South Wales Venetian Plastering Ltd | Construction | 2023 |
| South Wales Wrought Ironworks Ltd | Manufacturing | 2018 |
| Southern Pitts Dairy Ltd | Agriculture & fishing | 2014 |
| SPK Hakin Limited | Administrative & support | 2019 |
| SRH I&E Engineering Ltd | Professional & scientific | 2014 |
| SRS Pembs Limited | Construction | 2020 |
| SSC Invest UK Ltd | Financial services | 2017 |
| ST Davids Bunk Barns Ltd | Hospitality | 2016 |
| ST. Bride's Spa Hotel Limited | Hospitality | 1999 |
| St.Brides Bay Clothing Limited | Manufacturing | 2016 |
| Stable BOY Ltd | Wholesale & retail | 2026 |
| Stay West Ltd | Real estate | 2022 |
| Stedfast Limited | Manufacturing | 2012 |
| Steptoes Mechanical Services Ltd | Professional & scientific | 2023 |
| Steynton Wind Ltd | Energy | 2017 |
| Stockdale-Hughes Ltd. | Arts & recreation | 2010 |
| Store IT Pembs Ltd | Transport & logistics | 2020 |
| Street Shine Ltd | Administrative & support | 2024 |
| Strivewave Ltd | Wholesale & retail | 2025 |
| Stroke of Luck Mini Golf Ltd | Arts & recreation | 2026 |
| Sturley Operations Consultancy Limited | Administrative & support | 2017 |
| Sunbeam Holdings Ltd | Arts & recreation | 2025 |
| Sunset Sailing Ltd | Professional & scientific | 2025 |
| Switched on Solar Ltd | Construction | 2022 |
| Swizel & Co Ltd | Wholesale & retail | 2025 |
| Synapse Animal Health Consultancy Ltd | Professional & scientific | 2026 |
| T3115 Limited | Other services | 2014 |
| Tavik Ltd | Professional & scientific | 2025 |
| TBS Recycling Center Wales Ltd | Water & waste | 2022 |
| TBS Skip Hire & Recycling Ltd | Water & waste | 2022 |
| TC Pembs Ltd | Administrative & support | 2026 |
| Tclm Limited | Other services | 2022 |
| TEB Pembs Limited | Wholesale & retail | 2015 |
| Terry's Tiles Ltd | Wholesale & retail | 2010 |
| THE Avondale Ltd | Hospitality | 2024 |
| THE BIN Lady and Family Ltd | Water & waste | 2026 |
| THE Business Advice Bureau Ltd | Professional & scientific | 2018 |
| THE Car GUY Pembs Ltd | Wholesale & retail | 2026 |