| S&S EC Services LLP | | 2021 |
| S&S.Webshopping Ltd | Wholesale & retail | 2025 |
| S&T Hold Co Limited | Financial services | 2023 |
| S&T Seller Ltd | Wholesale & retail | 2025 |
| S-D-Consultants-Sdc Ltd. | Information & communication | 2023 |
| S. Bilgrami Consulting Ltd | Professional & scientific | 2016 |
| S.Walter Ltd | Real estate | 2025 |
| SAB Partners Limited | Real estate | 2026 |
| Saber Holdings Limited | Professional & scientific | 2025 |
| Sabia Solutions Ltd | Administrative & support | 2024 |
| Sable Platforms UK Ltd | Information & communication | 2025 |
| Sackman Property Investments Ltd | Real estate | 2023 |
| Sacred by SAM Ltd | Wholesale & retail | 2025 |
| Sacred Sounds Collective CIC | Health & social care | 2026 |
| SAD Entertainment Limited | Wholesale & retail | 2026 |
| Sadc Recruitment Consultants LLP | | 2026 |
| Sael Hub Ltd | Information & communication | 2026 |
| Safarico LLP | | 2023 |
| Safe Step Support CIC | Hospitality | 2026 |
| Safeplicity Ltd | Information & communication | 2007 |
| Safeppe Ltd | Wholesale & retail | 2025 |
| Safestyledeal Ltd | Manufacturing | 2025 |
| Safety Devices International Limited | Manufacturing | 2005 |
| Safety Devices Limited | Extraterritorial | 2010 |
| Saffron Marketing Ltd | Professional & scientific | 2024 |
| Safqore LLP | | 2024 |
| Sage Smith Property Ltd | Professional & scientific | 2024 |
| Sagely Creative Ltd | Manufacturing | 2022 |
| Saigon Sky Media Ltd | Wholesale & retail | 2025 |
| Sail and Swell Travel Ltd | Administrative & support | 2025 |
| Sailacre Ltd | Financial services | 2019 |
| Sair Limited | Transport & logistics | 2016 |
| Sakaye Social Worker Limited | Professional & scientific | 2008 |
| Sakuracorp Ltd | Information & communication | 2018 |
| Salerise Ltd | Wholesale & retail | 2025 |
| Sales Automation Ltd | Information & communication | 2026 |
| Sales Compass Ltd | Wholesale & retail | 2025 |
| Sales Force Technology Ltd | Wholesale & retail | 2024 |
| Sales Forge Digital Ltd | Professional & scientific | 2025 |
| Sales Pro Consulting Services Ltd | Information & communication | 2024 |
| Sales Sparki Ltd | Agriculture & fishing | 2025 |
| Salient Ventures Limited | Professional & scientific | 2021 |
| Sally-Anne Energetics Ltd | Health & social care | 2026 |
| Salma Chiffon Ltd | Wholesale & retail | 2025 |
| Salopian Mini Digger Hire Ltd | Administrative & support | 2025 |
| Salt PIG Studios Ltd | Information & communication | 2026 |
| Salter Engineering Services Ltd | Professional & scientific | 2024 |
| Salva Properties Ltd | Real estate | 2024 |
| Sameenandco Ltd | Wholesale & retail | 2024 |
| Samiecom Ltd | Wholesale & retail | 2025 |
| Samosas Haus Ltd | Wholesale & retail | 2025 |
| Samphire & Morel Limited | Extraterritorial | 2020 |
| Samt Group Ltd | Other services | 2024 |
| Samtron Cloud Limited | Information & communication | 2024 |
| Sanaina Ltd | Wholesale & retail | 2025 |
| Sanctuary Garden Designs Ltd | Professional & scientific | 2024 |
| Sand Energy Consulting Ltd | Mining & quarrying | 2023 |
| Sandav Limited | Real estate | 2013 |
| Sanjay Sharma Limited | Health & social care | 2018 |
| Sanoosi Limited | Wholesale & retail | 2026 |
| Santha Investments Limited | Real estate | 2021 |
| Sanvieira Properties Ltd | Real estate | 2025 |
| Sanvieira Publishing Ltd | Information & communication | 2025 |
| Sapienti Limited | Construction | 2011 |
| Sapphire Dwellings Ltd | Real estate | 2024 |
| Sapphire Homes (Midlands) Ltd | Health & social care | 2024 |
| SAR (Sourcing and Researching) Europe Co. Ltd | Hospitality | 2020 |
| Sardar Global Services Ltd | Wholesale & retail | 2025 |
| Sardulela Limited | Financial services | 2026 |
| Sarkraft Ltd | Construction | 2023 |
| Satisfying Lips Ltd | Information & communication | 2024 |
| Satosha Ltd. | Administrative & support | 2014 |
| Satya Devi Enterprise Ltd | Wholesale & retail | 2025 |
| Sava-Group Company L.P. | | 2017 |
| Savage Daughter Jewellery Ltd | Manufacturing | 2024 |
| Savin on Call Limited | Other services | 2011 |
| Savio Visione Ltd | Professional & scientific | 2014 |
| Savlamar Ltd | Wholesale & retail | 2023 |
| Savvy Babe Network Ltd | Other services | 2024 |
| Savvy Competitions Limited | Other services | 2025 |
| Savvy Helpers Ltd | Professional & scientific | 2023 |
| Savvy Squirrels Limited | Wholesale & retail | 2025 |
| Savvy Works Ltd | Manufacturing | 2025 |
| Savyora Solutions Ltd | Information & communication | 2026 |
| Sawaam Ltd | Wholesale & retail | 2022 |
| Saxon & Mesh Group Ltd | Financial services | 2026 |
| Saygames Ltd | Information & communication | 2026 |
| Sayooj & Brothers Trading Company Ltd | Wholesale & retail | 2025 |
| SB Aircraft Ltd | Manufacturing | 2025 |
| SB Forty Ltd | Administrative & support | 2025 |
| SB Media Inc Ltd | Professional & scientific | 2012 |
| SB Partenaire Ltd | Financial services | 2025 |
| SBS Commerce Ltd | Wholesale & retail | 2025 |
| Scalepoint Digital Solutions Limited | Wholesale & retail | 2026 |
| Scaleup Marketing Ltd | Wholesale & retail | 2024 |
| Scaliseditor Ltd | Other services | 2012 |
| Scapin Ltd | Information & communication | 2025 |
| Scargill Health Forest Ltd | Manufacturing | 2026 |
| Scented Diamonds LEX Consult Ltd | Professional & scientific | 2024 |
| SCH Acoustic Solutions Limited | Professional & scientific | 2016 |