| Byley Freeman's Limited | Transport & logistics | 2000 |
| Byley Stores & Garage Limited | Transport & logistics | 1956 |
| C & N Wyatt Ltd | Health & social care | 2014 |
| C&B Management Ltd | Hospitality | 2024 |
| Cameron Agricultural (Cheshire) Limited | Wholesale & retail | 2008 |
| Camperholiday Limited | Wholesale & retail | 2019 |
| Carefree Cruising (Boatshare) Limited | Wholesale & retail | 2006 |
| Carter-Vision Limited | Professional & scientific | 2018 |
| Celebrant Services KJC Limited | Other services | 2021 |
| Celltech Embryo Transfer Limited | Agriculture & fishing | 1999 |
| Centec International Limited | Manufacturing | 1994 |
| Chalis Property Investments and Management Limited | Real estate | 2016 |
| Chalmers Holdings Limited | Wholesale & retail | 2009 |
| Chalmers Investments Limited | Real estate | 2016 |
| Chalmers Property Developments Limited | Construction | 2015 |
| Chalmers Services LLP | | 2025 |
| Changestream Limited | Professional & scientific | 2011 |
| Chaos Agency Ltd | Wholesale & retail | 2024 |
| Charlesworths of Crewe Limited | Wholesale & retail | 1961 |
| Cheers Global Drinks Ltd | Wholesale & retail | 2024 |
| Chemclean Limited | Manufacturing | 2024 |
| Cheshire Brow Bar Ltd | Other services | 2022 |
| Cheshire Cctv and Data Services Limited | Administrative & support | 2017 |
| Cheshire Cheese (Middlewich) Ltd | Hospitality | 2024 |
| Cheshire Civils & Construction Ltd | Construction | 2025 |
| Cheshire East Restaurant Ltd | Hospitality | 2026 |
| Cheshire Jetforce Ltd | Administrative & support | 2026 |
| Cheshire Lasers Limited | Other services | 2008 |
| Cheshire Lawn Care Company Limited | Administrative & support | 2018 |
| Cheshire TAP Ltd | Hospitality | 2015 |
| Cheshire Tree Services Limited | Agriculture & fishing | 2023 |
| Cheshlet Limited | Real estate | 2020 |
| Cheshtekk Ltd | Professional & scientific | 2019 |
| Chimis Mexican Ltd | Hospitality | 2022 |
| Cjls Contract Solutions Limited | Professional & scientific | 2020 |
| Cjls Property Investments Limited | Real estate | 2019 |
| Ckeg Limited | Construction | 2024 |
| Clarke Property and Consulting Ltd. | Professional & scientific | 2012 |
| Clerisy Medical Writing Ltd | Professional & scientific | 2024 |
| Clifton Pearl Limited | Wholesale & retail | 2025 |
| Cloud Aerial Arts Limited | Arts & recreation | 2017 |
| Cloud Constructions Ltd | Information & communication | 2022 |
| CM Farriery Ltd | Agriculture & fishing | 2023 |
| Cogent Marketing Solutions Ltd | Other services | 2016 |
| Columbus Trading Limited | Wholesale & retail | 2002 |
| Community Concessions Ltd | Professional & scientific | 2019 |
| Complete Dairy Services Ltd | Manufacturing | 2022 |
| Complete Surfacing Solutions Ltd | Construction | 2019 |
| Concept Tiling Solutions NW Limited | Construction | 2012 |
| Connected Flow Management Ltd | Professional & scientific | 2025 |
| Connected Managementuk Ltd | Professional & scientific | 2025 |
| Contour Showers Limited | Manufacturing | 1978 |
| County Renewables Ltd | Construction | 2020 |
| Cranage Trade Cars Limited | Wholesale & retail | 2019 |
| Cross Lanes Farm Limited | Agriculture & fishing | 2012 |
| Crownstone Home Improvements Ltd | Construction | 2026 |
| CRS Property Group Limited | Real estate | 2022 |
| CRX Safety Ltd | Professional & scientific | 2020 |
| Cultivate Conference Ltd | Administrative & support | 2019 |
| Culverhouse Limited | Real estate | 2019 |
| Cw-Construct Limited | Construction | 2025 |
| CW10 Fastfood Limited | Hospitality | 2026 |
| Cyber Framework Solutions Ltd | Administrative & support | 2023 |
| Cycling Cafe CIC | Professional & scientific | 2023 |
| D V Foam Ltd | Manufacturing | 2017 |
| D&D Autos Ltd | Wholesale & retail | 2008 |
| Daborne Developments Ltd | Construction | 2023 |
| Daly Concepts Ltd | Professional & scientific | 2022 |
| Daniel East Music Limited | Arts & recreation | 2017 |
| Dariusz Wieclaw Ltd | Construction | 2017 |
| Dawn Resin Ltd | Construction | 2025 |
| Dawn Roofing & Repairs Ltd | Construction | 2025 |
| Dawn Roofs Ltd | Construction | 2024 |
| Deans Landscape and Maintenance Ltd | Administrative & support | 2025 |
| Delayed Flights Compensation Limited | Administrative & support | 2014 |
| Demon Performance Centre Ltd | Wholesale & retail | 2014 |
| Devnet Limited | Information & communication | 2008 |
| Dexter Fire Ltd | Professional & scientific | 2024 |
| DEY Motor Company Limited | Wholesale & retail | 2003 |
| Divine Decorators of Cheshire Ltd | Construction | 2021 |
| DJL Property Rentals Limited | Real estate | 2025 |
| Domestic and Commercial Air Conditioning Ltd | Construction | 2021 |
| DON Richardson Limited | Wholesale & retail | 1997 |
| Dottie Dances Ltd | Education | 2025 |
| Drakelow Gorse Farm Limited | Real estate | 2017 |
| Dreamcoat Windows Limited | Construction | 2017 |
| Drumbrick Developments Limited | Real estate | 2004 |
| DS & SS Property Services Limited | Real estate | 2021 |
| DS Mortgage Services Limited | Financial services | 2019 |
| Duncan Fulfilment Ltd | Transport & logistics | 2023 |
| Dutton Builders Merchants Limited | Wholesale & retail | 2013 |
| Dutton Civils Limited | Construction | 2019 |
| Dutton Commercial Middlewich Limited | Real estate | 2023 |
| Dutton Commercial Services Limited | Real estate | 2014 |
| Dutton Infrastructure Limited | Construction | 2020 |
| Dutton Plant Holdings Limited | Financial services | 2025 |
| Dutton Traffic Management Holdings Limited | Construction | 2018 |
| Dutton Traffic Management Services Limited | Construction | 2016 |
| DWX Projects Ltd | Real estate | 2025 |
| E-Forensic Solutions Limited | Information & communication | 2010 |