| SK Edifice Ltd | Construction | 2014 |
| SKA Music Limited | Arts & recreation | 2005 |
| Skerton & SON Limited | Construction | 1955 |
| Skialot Ltd | Hospitality | 2000 |
| Skoll Ltd. | Administrative & support | 1996 |
| SKP Systems Limited | Information & communication | 2003 |
| SKS Construction Services Limited | Other services | 2004 |
| SKS Ickenham Ltd | Wholesale & retail | 2006 |
| Sky Angel Ltd | Wholesale & retail | 2024 |
| Sky Comedy Limited | Professional & scientific | 1995 |
| Sky Electrical Limited | Construction | 1999 |
| Sky Group Finance Limited | Administrative & support | 2005 |
| Sky History Limited | Professional & scientific | 1995 |
| Sky Holdings Limited | Administrative & support | 2005 |
| Sky In-Home Service Limited | Information & communication | 1986 |
| Sky Limited | Professional & scientific | 1988 |
| Sky New Media Ventures Limited | Administrative & support | 1999 |
| Sky Operational Finance Limited | Financial services | 1994 |
| Sky Retail Stores Limited | Administrative & support | 2000 |
| Sky Subscribers Services Limited | Other services | 1989 |
| Sky Telecommunications Limited | Administrative & support | 2005 |
| Sky Telecommunications Services Limited | Administrative & support | 1993 |
| Sky Television Limited | Professional & scientific | 1980 |
| Sky UK Limited | Information & communication | 1994 |
| Sky Ventures Limited | Professional & scientific | 1995 |
| Skyblue Property Limited | Real estate | 2000 |
| Skye Estates Limited | Construction | 2003 |
| Skyline Building Ltd | Construction | 2025 |
| Skyline Homes & Developments Limited | Real estate | 2004 |
| Skytrak Travel Limited | Administrative & support | 2003 |
| Slap-Dash Designs Limited | Administrative & support | 2002 |
| SLB Props Ltd | Information & communication | 2025 |
| Slee Engineering Construction Limited | Construction | 2002 |
| Slime Hub Bagshot Ltd | Health & social care | 2026 |
| Slime Hub Basingstoke Ltd | Health & social care | 2026 |
| Slime Hub Wokingham Ltd | Health & social care | 2026 |
| SLJ Consultancy Hub Limited | Professional & scientific | 2024 |
| Slns Infotech Limited | Information & communication | 2016 |
| SM Computer Consultants Limited | Information & communication | 1993 |
| Small Business Support Services Limited | Professional & scientific | 2001 |
| Small Emerging Entrepreneur Division Limited | Extraterritorial | 1997 |
| Smart Electrical&Design Ltd | Construction | 2018 |
| Smart-Tactics Limited | Information & communication | 2001 |
| Smartc Limited | Information & communication | 2002 |
| Smartech Systems Limited | Financial services | 1999 |
| Smartsoft (UK) Ltd | Hospitality | 2000 |
| Smash and Peach Limited | Professional & scientific | 2014 |
| SMB Networks Limited | Construction | 2002 |
| SME Properties Holding Ltd | Hospitality | 2020 |
| Smith, Taylor & Potter International Limited | Transport & logistics | 2000 |
| SMO Consultants Limited | Professional & scientific | 2006 |
| Smyth Properties Ltd | Real estate | 2017 |
| Snipe Investment Ltd | Real estate | 2018 |
| SNJ Link Properties Limited | Real estate | 2018 |
| Snowshield Limited | Real estate | 1992 |
| Snpk Management Limited | Professional & scientific | 2003 |
| Soberano Estates Limited | Real estate | 2014 |
| Software Team Limited | | 1987 |
| Sokhi Construction (UK) Limited | Construction | 1996 |
| Sokhi Property London Limited | Real estate | 2024 |
| Solah Ltd | Wholesale & retail | 2020 |
| Solo Concepts Limited | Manufacturing | 2005 |
| Solutions Royale Ltd | Professional & scientific | 2007 |
| Solv Finance Limited | Financial services | 2004 |
| Something Moore Ltd | Financial services | 2023 |
| Somswe Ltd | Administrative & support | 2016 |
| Sondar UK Ltd | Construction | 2020 |
| Soneji and Co Limited | Professional & scientific | 2002 |
| Sonica Services Ltd | Manufacturing | 2003 |
| Sonik Products Limited | Wholesale & retail | 1996 |
| Soothing Touch Limited | Education | 2002 |
| Soul Foods Limited | Professional & scientific | 2002 |
| Soul-E Holistics Ltd. | Other services | 2007 |
| Sound Running Ltd | Information & communication | 2022 |
| Source Partners Limited | Information & communication | 2001 |
| South East Alexandra Avenue Limited | Real estate | 1996 |
| South Quay Plaza Management Limited | Real estate | 1989 |
| Southall Black Sisters | Health & social care | 1995 |
| Southall Halal Meat Limited | Hospitality | 1993 |
| Southall Heating Supplies Ltd | Wholesale & retail | 2000 |
| Southern Comfort Upholstery Limited | Manufacturing | 1982 |
| Southern Counties (Distributions) Limited | Real estate | 1971 |
| Southern Rebel Limited | Information & communication | 1999 |
| Southside Limited | Real estate | 1994 |
| Southwestern Consulting Services Limited | Information & communication | 2001 |
| SP Swindon Ltd | Hospitality | 2024 |
| Spa Accounting Limited | Professional & scientific | 2002 |
| Space SET Limited | Information & communication | 2011 |
| Space Studios (London) Limited | Arts & recreation | 1993 |
| Spacehold Limited | Administrative & support | 1995 |
| Spacers Tile and Wood Flooring Limited | Wholesale & retail | 1981 |
| Sparrow Properties Limited | Real estate | 2002 |
| Sparta Cleaning Contractors Ltd | Administrative & support | 2002 |
| Spartacus Enterprises Ltd. | Transport & logistics | 1993 |
| Spearhead Couriers Limited | Transport & logistics | 2002 |
| Spec Computers Ltd. | Information & communication | 1993 |
| Speclink Limited | Professional & scientific | 2007 |
| Spectrum Investments (UK) Limited | Real estate | 2009 |
| Speedbird Management Limited | Extraterritorial | 1997 |
| Speedy Radio Cars Limited | Transport & logistics | 2007 |