| SGF Hartlepool Ltd | Hospitality | 2020 |
| SGF Newcastle Ltd | Hospitality | 2020 |
| SGT Landscapes Ltd | Manufacturing | 2014 |
| SH & Co Properties Ltd | Hospitality | 2010 |
| SH Askew | Administrative & support | 2011 |
| SH Property Developments Limited | Real estate | 2016 |
| SHA Global Ltd | Professional & scientific | 2012 |
| Shaban Khan Rental Limited | Transport & logistics | 2014 |
| Shack Properties Limited | Real estate | 2022 |
| Shadow Health Ltd | Information & communication | 2026 |
| Shadow Nutrients Limited | Wholesale & retail | 2026 |
| Shafi Investments Leeds Limited | Real estate | 2023 |
| Shafi Ventures Ltd | Hospitality | 2018 |
| Shahjalal Asian Food Store Ltd | Wholesale & retail | 2024 |
| Sham & Co NE Ltd | Wholesale & retail | 2025 |
| Shameran Market (NE) Limited | Wholesale & retail | 2025 |
| Shamrocks Micro Bar Ltd | Hospitality | 2025 |
| Shane Iceton Heating & Plumbing Ltd | Construction | 2021 |
| Shapen Limited | Financial services | 2015 |
| Sharazur Ltd | Hospitality | 2019 |
| Shareef Protection Solution Ltd | Administrative & support | 2025 |
| Shaun Okelly Limited | Other services | 2022 |
| Shaw Estates (Holdings) Ltd | Professional & scientific | 2022 |
| Shaw Manufacturing Limited | Professional & scientific | 2022 |
| Shaw Property Developments Ltd | Construction | 2016 |
| Shawarma Jacks Ltd | Hospitality | 2022 |
| Shawarma Village Limited | Hospitality | 2024 |
| SHD Cleaners Ltd | Administrative & support | 2025 |
| SHE Hair Retail Ltd | Other services | 2022 |
| SHE OIL & GAS Limited | Administrative & support | 2013 |
| Shearwater Management Ltd | Agriculture & fishing | 2023 |
| Sheela Hair Beauty Ltd | Other services | 2024 |
| Shehab Commercial Kitchens Limited | Construction | 2021 |
| Shehab Extraction System Ltd | Other services | 2026 |
| Shehroz Tanveer Logistics Ltd | Transport & logistics | 2025 |
| Sheila May's Carpets of Teesside Limited | Construction | 2012 |
| Shekinah Properties Limited | Real estate | 2023 |
| Shell View Limited | Real estate | 2025 |
| Shelton Minimarket Ltd | Wholesale & retail | 2023 |
| Shera Auto Ltd | Wholesale & retail | 2025 |
| Sheriden Limited | Wholesale & retail | 2006 |
| Sheriftrading Ltd | Wholesale & retail | 2019 |
| Sherland Property Opco Limited | Real estate | 2012 |
| Shetlandsprayservices Ltd | Construction | 2026 |
| Shevington Grove 1964 Limited | Extraterritorial | 2014 |
| Shexany Limited | Other services | 2026 |
| Shez Autos Limited | Wholesale & retail | 2021 |
| Shields Electrical Services Ltd | Construction | 2026 |
| Shifaazfashion Ltd | Wholesale & retail | 2025 |
| Shikoi Ltd | Information & communication | 2025 |
| Shinwari Catering and Events Ltd | Hospitality | 2023 |
| Ship's Butcher Ltd | Wholesale & retail | 2024 |
| Shipadvisor Limited | Transport & logistics | 2024 |
| Shipping Project Services Limited | Administrative & support | 2009 |
| Shippit Private Limited | Wholesale & retail | 2026 |
| Shire Aggregates Bulk Limited | Mining & quarrying | 2003 |
| Shiva Goods and Services Limited | Wholesale & retail | 2026 |
| Shiverbug Studios Ltd | Information & communication | 2025 |
| Shjf Properties Limited | Real estate | 2023 |
| Shoaib Painting and Decorations Limited | Construction | 2026 |
| SHOAIB29 Ltd | Transport & logistics | 2026 |
| Shopmax Limited | Wholesale & retail | 2025 |
| Shoprush Limited | Wholesale & retail | 2023 |
| Shreyamanat Desi Cuisine Limited | Hospitality | 2026 |
| SI Ventures LLP | | 2010 |
| Si-Tech Global Ltd | Professional & scientific | 2023 |
| SIA - Skin Inspired Aesthetics Ltd | Other services | 2024 |
| Sialtrove Ltd | Wholesale & retail | 2024 |
| Sibary Property Ltd | Real estate | 2017 |
| Sideshow Broadcasting Ltd | Information & communication | 2023 |
| Sido Development and Management Limited | Real estate | 2018 |
| Sido Engineering Services Limited | Professional & scientific | 2017 |
| SIG Global Holdings Ltd | Financial services | 2022 |
| Siglow Ltd | Administrative & support | 2020 |
| Sigma Plantfinder Limited | Wholesale & retail | 2014 |
| Sigma TEC Ltd | Wholesale & retail | 2025 |
| Sigma Training Ltd | Professional & scientific | 2021 |
| Signal Tech Limited | Construction | 2022 |
| Signature Products Limited | Wholesale & retail | 2024 |
| Signature Stitches Limited | Manufacturing | 2025 |
| Signet Tech Limited | Professional & scientific | 2015 |
| Signworx North East Limited | Professional & scientific | 2015 |
| Signwriter Films Limited | Information & communication | 2016 |
| Silent Spring Consultants Ltd | Professional & scientific | 2022 |
| Silver Dragon Cosplay Ltd | Wholesale & retail | 2023 |
| Silver Fern Global Traders Limited | Wholesale & retail | 2025 |
| Silver Lining Animation Ltd | Information & communication | 2017 |
| Silver Star Ykchow Ltd | Hospitality | 2021 |
| Silver Wolf Operations Ltd | Professional & scientific | 2024 |
| Silverline Global Property Market Ltd | Real estate | 2025 |
| Silvia Properties Limited | Real estate | 1988 |
| Simon Mcallen Lift Installations Ltd | Construction | 2003 |
| Simon Norman Limited | Professional & scientific | 2011 |
| Simon Welby Ltd | Agriculture & fishing | 2012 |
| Simos Pizzeria NE Ltd | Hospitality | 2024 |
| Simotickets Ltd | Wholesale & retail | 2025 |
| Simple Products Ltd | Wholesale & retail | 2016 |
| Simplex Global Solutions Ltd | Information & communication | 2012 |
| Simply Brickwork Ltd | Construction | 2008 |
| Simply Homes NE Limited | Real estate | 2021 |