| D & E Watson Properties Limited | Real estate | 2000 |
| D & L O'Neill Accountants Limited | Professional & scientific | 2003 |
| D & S O'Shea Limited | Wholesale & retail | 2026 |
| D L Farrell Ltd | Construction | 2019 |
| D Properties Limited | Construction | 2002 |
| D"N"A Construction Limited | Construction | 2001 |
| D. G. Joinery & Building Contractors Ltd | Construction | 2012 |
| D. MAC Plumbing & Heating (Wirral) Ltd | Administrative & support | 2009 |
| D. TEC International Limited | Other services | 1996 |
| D.V.R. Installations (1994) Limited | Construction | 1993 |
| Danmedix Aesthetics Limited | Health & social care | 2019 |
| Danwood Property Limited | Real estate | 2024 |
| Data CUT Engineering Limited | Manufacturing | 1980 |
| Dataunit Limited | Construction | 1998 |
| David Woods Plumbing & Heating Limited | Construction | 2005 |
| Daydreams Nursery Limited | Health & social care | 2007 |
| Daylocal Developments Limited | Real estate | 1998 |
| DCN Services NW Ltd | Real estate | 2018 |
| Denis Local Store Limited | Wholesale & retail | 2020 |
| Depo Wholesale UK Ltd | Wholesale & retail | 2020 |
| Derby Park Limited | Extraterritorial | 2006 |
| Desire Energy Solutions Limited | Other services | 2025 |
| Devil Chip Challenge Ltd | Manufacturing | 2020 |
| Devilred Limited | Information & communication | 2007 |
| Devonshire House Limited | Hospitality | 2000 |
| Dexlec Rewinds Limited | Manufacturing | 1990 |
| Digital Media Boutique Ltd | Professional & scientific | 2021 |
| Dingwall Autos Limited | Wholesale & retail | 1981 |
| Dirk Advanced Building Materials Limited | Transport & logistics | 1989 |
| DJB Medical Limited | Health & social care | 2017 |
| DMH Medical Ltd | Professional & scientific | 1999 |
| Dogan Elif Limited | Hospitality | 2026 |
| Doorway to Value Limited | Extraterritorial | 2005 |
| Dormus Apollo Ltd | Real estate | 2025 |
| Douglas Fairless Partnership Limited | Professional & scientific | 1999 |
| Downey & Nash Associates Limited | Professional & scientific | 2006 |
| Downland Bedding Company Limited(The) | Manufacturing | 1946 |
| DR C Young Limited | Health & social care | 2019 |
| DR Imran Rafi Limited | Health & social care | 2008 |
| DR R Parslew Partnership Limited | Hospitality | 2004 |
| DR SAM Medical Limited | Health & social care | 2025 |
| Droylsden Football Club Limited | Arts & recreation | 1975 |
| Drusin Limited | Wholesale & retail | 1983 |
| DS Repro Limited | Manufacturing | 2007 |
| DSR Independent Insurance Consultants Limited | Financial services | 2006 |
| Duty Barbers Ltd | Other services | 2020 |
| DWL Promotions Limited | Arts & recreation | 2003 |
| Dynamic Load Testing Limited | Manufacturing | 2007 |
| E & J Holdings Liverpool Limited | Financial services | 2026 |
| E. & E. Grossi Limited | Hospitality | 1977 |
| E.A. Clare & SON Limited | Manufacturing | 1974 |
| E.G. Seiglow Limited | | 1984 |
| E.H. Jones (Paints) Limited | Manufacturing | 1980 |
| E.K.Laurie Limited | Wholesale & retail | 1947 |
| E.M.H. International Limited | Manufacturing | 1979 |
| E.O. Cottam & Sons Limited | Construction | 1984 |
| EDB Fire Protection Limited | Construction | 2026 |
| Edgetime Properties Limited | Real estate | 2006 |
| Edgetime Services Limited | Water & waste | 2007 |
| Edmund a. Stephens Limited | Manufacturing | 1978 |
| Edmund Barton Limited | Manufacturing | 1961 |
| Edward & Chris Investments Limited | Real estate | 2006 |
| Edwards & Hampson Limited | Construction | 1985 |
| EFT Group Holdings Limited | Real estate | 2025 |
| Egan Architects Ltd | Professional & scientific | 2022 |
| Elbow Lane Commercial Limited | Real estate | 2021 |
| Eldapoint Limited | Other services | 1973 |
| Elerbanks Limited | Construction | 1950 |
| Elude Cafe Bar (Liverpool) Ltd | Hospitality | 2006 |
| Emani Software Limited | Information & communication | 2004 |
| Emerald SAM Properties Ltd | Real estate | 2022 |
| EMH Services Limited | Construction | 2003 |
| Emigen Limited | Information & communication | 2003 |
| Emporda Ltd | Real estate | 2004 |
| Entertainment Simulators Co. Limited | Arts & recreation | 1998 |
| Equipe Environmental Limited | Administrative & support | 1999 |
| Erin Care UK Ltd | Health & social care | 2014 |
| European Weld Inspection Services Limited | Professional & scientific | 2006 |
| Evans Bellhouse Limited | Wholesale & retail | 2001 |
| Evans Brothers (Southport) Limited | Construction | 1958 |
| Everett Commercial Limited | Professional & scientific | 2004 |
| Evergreen Produce Ltd | Wholesale & retail | 2006 |
| F. Chadwick Joinery Limited | Construction | 2002 |
| F.D.Hughes(Liverpool)Limited | Wholesale & retail | 1954 |
| FAB Life Properties Ltd | Real estate | 2024 |
| Fabbies Limited | Administrative & support | 2003 |
| Fact Liverpool | Arts & recreation | 1989 |
| Fact Trading Limited | Arts & recreation | 2003 |
| FAK Services Limited | Health & social care | 1997 |
| Falcon Green Limited | Real estate | 2002 |
| Falconer Chester Hall Limited | Professional & scientific | 2000 |
| Family Christmas Savings Club Limited | Administrative & support | 2006 |
| Fastlane Autocare Autocentres Limited | Wholesale & retail | 2024 |
| FAZ Ltd | Wholesale & retail | 2007 |
| Fennelly Art Limited | Arts & recreation | 2004 |
| Ferguson Pet Care Ltd | Agriculture & fishing | 2022 |
| Ferroday Limited | Information & communication | 1993 |
| Ffadland Property Ltd | Real estate | 2024 |
| Find Hypnosis Limited | Health & social care | 2004 |
| Finndoc Medical Services Limited | Health & social care | 2019 |