| Saxby Hatfield Limited | Professional & scientific | 2021 |
| Saxby Road COB Shop Ltd | Wholesale & retail | 2017 |
| Saxelbye Finance Ltd | Health & social care | 2005 |
| Saxondale Doggy Daycare Ltd | Agriculture & fishing | 2026 |
| SB and BB Properties (UK) Limited | Real estate | 2024 |
| SB Hospitality T/A Apurba Limited | Hospitality | 2023 |
| Scalford Brook Property Ltd | Real estate | 2016 |
| Scalford Country House Ltd | Hospitality | 2018 |
| Scalford Property Development Limited | Construction | 2014 |
| Schroeder Farms Limited | Agriculture & fishing | 1997 |
| Scotsborough Castle Limited | Extraterritorial | 1994 |
| Scott and Parsons Limited | Wholesale & retail | 2024 |
| Scott Greet & 2 VEG Limited | Wholesale & retail | 2014 |
| Secco UK Limited | Professional & scientific | 2024 |
| Secure Containers Limited | Manufacturing | 2020 |
| Security Governance Limited | Extraterritorial | 2024 |
| Sedgewick Stone Limited | Construction | 2018 |
| Seeds Day Service Ltd | Health & social care | 2024 |
| Seedse Ltd | Education | 2015 |
| Seewell Mobile Eyecare Limited | Health & social care | 2025 |
| Sennet Professional Indemnity Limited | Financial services | 1997 |
| Sensopart UK Limited | Administrative & support | 1997 |
| SER & JMT Limited | Administrative & support | 2024 |
| SFB Land Limited | Real estate | 2019 |
| SFE Chetwode Limited | Administrative & support | 2021 |
| SG Pipeline Services Limited | Construction | 2016 |
| SGA Courier Ltd | Manufacturing | 2018 |
| SH & CS Ltd | Real estate | 2012 |
| Shane Mousley & SON Ltd | Extraterritorial | 2021 |
| Shapeform Limited | Real estate | 1996 |
| Shapeform New Property Limited | Real estate | 2019 |
| Sharkey Forestry Limited | Agriculture & fishing | 2014 |
| Sharper Future Ltd | Information & communication | 2025 |
| Shaw & Simonsen Limited | Professional & scientific | 2024 |
| Shdw Ltd. | Information & communication | 2021 |
| SHE Sparks Ltd | Construction | 2016 |
| Sheikh Consultancy Ltd | Financial services | 2020 |
| Sheldan Services Ltd | Professional & scientific | 2025 |
| Sherbrook Agricultural Ltd | Agriculture & fishing | 2014 |
| Sheridon UK Limited | Transport & logistics | 2000 |
| Sherrard ST Bar & Food Ltd | Hospitality | 2025 |
| Sherrenham Ltd. | Financial services | 2020 |
| Sherwood Farms Holdings Limited | Financial services | 2023 |
| Sherwood Farms,Limited | Agriculture & fishing | 1940 |
| Shetland Line Limited | | 1975 |
| Shilohrich Limited | Manufacturing | 2018 |
| Shoddy & Mungo Limited | Professional & scientific | 2012 |
| Shoomaker Ltd | Wholesale & retail | 2007 |
| Shoulers Auctions Limited | Wholesale & retail | 2026 |
| Shree Shivkrupanand Swami Trust UK | Health & social care | 2012 |
| Siark Ltd | Information & communication | 2007 |
| Signature Auto Service Ltd | Wholesale & retail | 2025 |
| Silverdale Lettings Ltd | Real estate | 2016 |
| SIM Landscapes Limited | Administrative & support | 2018 |
| Simmonds Vehicles & Repairs Limited | Wholesale & retail | 2024 |
| Simon Jeffreys Ltd | Agriculture & fishing | 2009 |
| Simons & Simons Properties Limited | Real estate | 2025 |
| Simons Electrical Services Ltd | Construction | 2018 |
| Simply Morzine Limited | Administrative & support | 1997 |
| Simtec Distribution Limited | Administrative & support | 2007 |
| Simtec Solutions Limited | Administrative & support | 2001 |
| Sitelens Ltd | Information & communication | 2026 |
| SJG Impact Ltd | Professional & scientific | 2025 |
| SJP Jerseywear Ltd | Manufacturing | 2015 |
| SK Stamford Co Ltd | Other services | 2023 |
| SKB Catering Limited | Hospitality | 2024 |
| Skills Division Ltd | Construction | 2025 |
| Skinova Aesthetics Clinic Limited | Information & communication | 2022 |
| Sktb Limited | Transport & logistics | 2016 |
| Skyblu Solutions Limited | Administrative & support | 2012 |
| Skyla Farrell Limited | Other services | 2023 |
| Skylark Farm Ltd | Agriculture & fishing | 2024 |
| Skysoft IT Solutions Ltd | Wholesale & retail | 2012 |
| Slam Clothing Ltd | Financial services | 2021 |
| Sleepy Sheep Limited | Other services | 2000 |
| SLF Commercial Limited | Wholesale & retail | 2017 |
| SLP Property Consultancy Ltd | Professional & scientific | 2026 |
| SLS Business Solutions Ltd | Professional & scientific | 2010 |
| SM Marshall Management Ltd | Wholesale & retail | 2021 |
| Smallpork Holdings Limited | Financial services | 2023 |
| Smart Fire Safety Ltd | Professional & scientific | 2022 |
| Smart Works Civils Ltd | Construction | 2026 |
| SMH Haulage Ltd | Transport & logistics | 2014 |
| Smiley-Jones Limited | Professional & scientific | 2013 |
| Smith & Dough Ltd | Hospitality | 2005 |
| Smith and Christian Pubs Limited | Hospitality | 2018 |
| SMS Events Ltd | Education | 2021 |
| Snap POD Ltd | Manufacturing | 2025 |
| Snowdrop Group Ltd | Extraterritorial | 2017 |
| SNP Medical Transport Ltd | Other services | 2017 |
| Sockista Limited | Wholesale & retail | 2020 |
| Softwarebox Solutions Limited | Information & communication | 2019 |
| Solex Associates Limited | Professional & scientific | 2009 |
| Solve for ALL Ltd | Professional & scientific | 2024 |
| Solving Construction Ltd | Information & communication | 2024 |
| Somerby Equestrian Centre Limited | Arts & recreation | 1999 |
| Somerby Riding Centre LLP | | 2018 |
| SON Investment Ltd | Real estate | 2026 |
| Sophie Cullumbine Ltd | Professional & scientific | 2020 |
| Soreen Limited | Extraterritorial | 2014 |