| Silvaco Ltd | Agriculture & fishing | 2012 |
| Simand Consultancy Ltd | Information & communication | 2016 |
| Simmons IT Services Limited | Information & communication | 2018 |
| Simo’S 2 Barber Ltd | Other services | 2025 |
| Simply EAR WAX Removal Ltd | Health & social care | 2022 |
| Simply Magical Ltd | Manufacturing | 2019 |
| Site Specialists Ltd | Construction | 2025 |
| SJ Logistics Group Limited | Transport & logistics | 2023 |
| Sketchley Consulting Limited | Professional & scientific | 2025 |
| Skin Expert Direct Ltd | Wholesale & retail | 2023 |
| SL Tax Solutions Limited | Professional & scientific | 2024 |
| Slic Electrical Ltd | Energy | 2020 |
| Smart Commercial Ventures Limited | Professional & scientific | 2008 |
| Smartech Engineering Solutions Ltd | Real estate | 2025 |
| Smarter Heating Solutions Limited | Construction | 2019 |
| Smartissh Ltd | Construction | 2024 |
| Smile Harmony Ltd | Health & social care | 2024 |
| SN10 Ltd | Financial services | 2021 |
| Snapdragons (Holdings) Ltd | Real estate | 2021 |
| Snapdragons Nurseries Limited | Education | 2002 |
| Snapshot Rentals Ltd | Administrative & support | 2023 |
| Snee Fish Limited | Hospitality | 2026 |
| SNY Convenience Stores Ltd | Wholesale & retail | 2023 |
| Sofa Brands International Limited | Professional & scientific | 2005 |
| Soil Hub International Ltd | Professional & scientific | 2014 |
| Soil Hub Ltd | Professional & scientific | 2016 |
| Soilbiolab Ltd | Professional & scientific | 2014 |
| Solarsolutionswilts Ltd | Administrative & support | 2025 |
| Sound Marketing (South-West) Limited | Professional & scientific | 1997 |
| Sound Networks (SW) Limited | Administrative & support | 2017 |
| Sound Wheels Ltd | Transport & logistics | 2019 |
| Soundm Ltd | Information & communication | 2011 |
| South Downs Sailing Ltd | Arts & recreation | 2017 |
| South of Heaven Body Art Limited | Other services | 2010 |
| South West Auto Trimming Limited | Wholesale & retail | 2015 |
| South West Fallen Stock Ltd | Agriculture & fishing | 2026 |
| South West General Building & Landscape Services Ltd | Construction | 2026 |
| Southern Counties Honey Ltd | Manufacturing | 2023 |
| Southern Safari Co. Ltd | Hospitality | 2025 |
| Spring Education Ltd | Education | 2025 |
| Squid Marketing Limited | Other services | 2020 |
| SS Carpentry & Building Solutions Limited | Construction | 2016 |
| Starlight Beauty Ltd | Other services | 2019 |
| Start Management Consulting Limited | Professional & scientific | 2018 |
| Stashgeo Ltd | Professional & scientific | 2025 |
| Staunchsecuritymanagement Ltd | Administrative & support | 2020 |
| Stay Dialled Run Ltd | Wholesale & retail | 2026 |
| Stephen J Hale Building Contractor Limited | Construction | 2000 |
| Stepthroughthedoor Limited | Other services | 2023 |
| Stonehenge Self Storage Ltd | Transport & logistics | 2025 |
| Stranger Nights Paranormal Ltd | Other services | 2020 |
| Studio 2012 Limited | Information & communication | 2020 |
| Studio Nalu Limited | Arts & recreation | 2026 |
| Succeed With Dyslexia Limited | Education | 2022 |
| Sundial Management Limited | Professional & scientific | 2000 |
| Super Gift Market Ltd | Wholesale & retail | 2025 |
| Swan Decorating Limited | Construction | 2013 |
| Swan Renovations Ltd | Construction | 2014 |
| Sweetpea Catering Ltd | Hospitality | 2018 |
| Switch Tyre Ltd | Wholesale & retail | 2012 |
| Syhol Limited | Information & communication | 2015 |
| T & B Properties Limited | Real estate | 2014 |
| T J Professional Builders Ltd | Construction | 2012 |
| T J Regler Limited | Wholesale & retail | 2018 |
| T&S LUX Electrical Ltd. | Administrative & support | 2001 |
| T&S Rentals Ltd | Hospitality | 2015 |
| Tabitha Properties Limited | Real estate | 2022 |
| Taco Turco Ltd | Hospitality | 2025 |
| Tailleur-Made Ltd | Professional & scientific | 2012 |
| Talbot Mills Limited | Real estate | 2017 |
| Talkwire Holdings Limited | Information & communication | 2025 |
| Talkwire Limited | Information & communication | 2001 |
| Tang & Fussell Ltd | Health & social care | 2019 |
| Tasty by T Ltd | Hospitality | 2025 |
| Tate Accounting Services LLP | | 2016 |
| Taurus Industrial Services Limited | Wholesale & retail | 2006 |
| TAV18 Company Ltd | Hospitality | 2022 |
| TAZ Consulting Ltd | Professional & scientific | 2010 |
| TDP Thatching Ltd | Construction | 2025 |
| Tea Inc. Limited | Wholesale & retail | 2013 |
| Teamsyncalliance Limited | Professional & scientific | 2024 |
| Tech Crossing Limited | Information & communication | 2021 |
| Teep Properties Ltd | Real estate | 2018 |
| TEN Hides Distillery Ltd | Manufacturing | 2020 |
| TF Electrics Limited | Construction | 2021 |
| TG Cooper Contracting Limited | Administrative & support | 2006 |
| Thames Medical Limited | Manufacturing | 1994 |
| THE Carpenters Workshop Limited | Manufacturing | 2024 |
| THE Contemporary Furniture Company Limited | Extraterritorial | 2005 |
| THE Finest Kind Roofing and Building Limited | Construction | 2024 |
| THE Fire Alarm Consultancy Limited | Public administration | 1998 |
| THE Golf Bar Ltd | Wholesale & retail | 2024 |
| THE Growth Flywheel Limited | Professional & scientific | 2021 |
| THE Ivoirie Clinic Ltd | Wholesale & retail | 2023 |
| THE Laycock PUB Company Ltd | Hospitality | 2024 |
| THE Lighting Superstore Limited | Wholesale & retail | 2011 |
| THE Lounge Co. (Furniture) Limited | Wholesale & retail | 2016 |
| THE Markem Partnership Ltd | Professional & scientific | 2004 |
| THE Market Tavern Melksham Ltd | Hospitality | 2026 |
| THE Natural Stone Tile Gallery Limited | Wholesale & retail | 2008 |