| S J Perry Capital Limited | Professional & scientific | 2014 |
| S&J Forecourt Limited Limited | Wholesale & retail | 2024 |
| Seven Earth Ltd | Professional & scientific | 2022 |
| Shah Holdings Ltd | Real estate | 2019 |
| Sharp Construction Limited | Information & communication | 2016 |
| Sharp EYE Instructional Design Ltd | Professional & scientific | 2024 |
| Sharps Mobile Bar Ltd | Hospitality | 2025 |
| Shuttlewood Clarke Trading Limited | Hospitality | 2011 |
| Shyamalam Limited | Health & social care | 2023 |
| Sign Direct Limited | Manufacturing | 2003 |
| Simon’S Courier Driver Ltd | Transport & logistics | 2026 |
| SJ Perry (Cauldcoats Farm) Limited | Professional & scientific | 2017 |
| Skin Health & Wellbeing Ltd | Other services | 2021 |
| SKS Engineering Limited | Professional & scientific | 2025 |
| SLB Cleaning Services Ltd | Administrative & support | 2019 |
| SMA Forecourt Ltd | Wholesale & retail | 2024 |
| Smoke and Bowl Ltd | Extraterritorial | 2024 |
| Snowball Community Ltd | Information & communication | 2022 |
| Soar Sound CIC | Information & communication | 2022 |
| South Charnwood High School | Education | 2013 |
| Spicenest Ltd | Hospitality | 2023 |
| Sporting Markfield Sports Club Ltd | Arts & recreation | 2021 |
| SSR Fashions Ltd | Manufacturing | 2013 |
| Stairlift and Mobility Solutions Ltd | Manufacturing | 2024 |
| Stanton Under Bardon Community Primary School | Education | 2013 |
| Steel Aquatics Ltd | Agriculture & fishing | 2025 |
| Stephen Howgill Design Ltd | Professional & scientific | 2010 |
| Straight Talkin' Records Ltd | Information & communication | 2013 |
| Sygnature Workwear Limited | Wholesale & retail | 2002 |
| T. Pearce Limited | Transport & logistics | 2003 |
| T.E.K. Test Station Limited | Wholesale & retail | 2012 |
| Tackout Ltd | Wholesale & retail | 2020 |
| Talent Cricket Limited | Wholesale & retail | 2026 |
| Temple Plant Hire Limited | Administrative & support | 2014 |
| THE Greyhound (Botcheston) Limited | Real estate | 2018 |
| THE Markfield Institute of Higher Education | Education | 2008 |
| THE Motor Medics (Midlands) Ltd | Wholesale & retail | 2020 |
| THE Studio Partnership Limited | Wholesale & retail | 2001 |
| THE Unlikely Landlord Ltd | Real estate | 2026 |
| Three Blind Mice Productions Ltd | Information & communication | 2020 |
| Tithe Farm Holdings Limited | Financial services | 2025 |
| Tollgate Design Limited | Administrative & support | 2015 |
| Tomlinsons Kennels Ltd | Other services | 2020 |
| Trade Price Windscreens Ltd | Wholesale & retail | 2000 |
| Tramps Limited | Extraterritorial | 1986 |
| Translation Link Ltd | Professional & scientific | 2016 |
| Trever Suhenly Limited | Wholesale & retail | 2023 |
| Twinkle Toes Treasures Ltd | Wholesale & retail | 2012 |
| Tyrebox Ltd | Wholesale & retail | 2026 |
| UK Bricktransport Ltd | Transport & logistics | 2020 |
| Uptonsteel Holdings Limited | Financial services | 2023 |
| Vascular Science Services Ltd | Health & social care | 2025 |
| Vienna Zero SIX Limited | Professional & scientific | 2006 |
| W.R. Cleaning and Maintenance Limited | Administrative & support | 2003 |
| Welovecarz Ltd | Wholesale & retail | 2019 |
| Whippycow Limited | Wholesale & retail | 2025 |
| Willows Cafe Marfield Ltd | Hospitality | 2025 |
| Wills Tech & Finance Ltd | Real estate | 2019 |
| WIN Marketing Europe Limited | Professional & scientific | 1989 |
| Wood Farm MLB Holdings Limited | Real estate | 2023 |
| World Products Ltd | Wholesale & retail | 2014 |
| Xira Ltd | Wholesale & retail | 2026 |