| Revision Recruitment Limited | Administrative & support | 2016 |
| Rhochi Architecture & Design Limited | Professional & scientific | 2018 |
| Rhonda Park Consulting Ltd | Administrative & support | 2015 |
| Rhonda Park Investments Ltd | Real estate | 2024 |
| Richard Moore Engineering Ltd | Extraterritorial | 2013 |
| Richard Yardy (2002) Limited | Construction | 2002 |
| Richmond & Vawser Ltd | Professional & scientific | 2024 |
| Ride Fenland Ltd | Arts & recreation | 2026 |
| Right Books Limited | Professional & scientific | 2001 |
| Rivertree Ltd | Information & communication | 2015 |
| RJW Construction Services Ltd | Construction | 2025 |
| RKA Glove UP CIC | Arts & recreation | 2023 |
| RME (Europe) Limited | Extraterritorial | 2013 |
| RN Energy Ltd | Construction | 2018 |
| ROB Lincoln Agencies Ltd | Extraterritorial | 2016 |
| Robinhood Car Wash Ltd | Administrative & support | 2019 |
| Roen Civils and Building Ltd | Construction | 2022 |
| Rowe Farming Limited | Agriculture & fishing | 2004 |
| Rowneytech Ltd | Education | 2020 |
| ROY Fisher Groundworks (March) Ltd | Construction | 2004 |
| RSA Property Developments Ltd | Construction | 2018 |
| RTS Trade Plastering Supplies Limited | Wholesale & retail | 2022 |
| Russell Investment Properties Ltd | Real estate | 2020 |
| Rutterford Construction Ltd | Construction | 2020 |
| S & W (Group) 2026 Limited | Professional & scientific | 2026 |
| S & W (Group) Holdco 2026 Limited | Financial services | 2026 |
| S & W (Group) Holdings Limited | Professional & scientific | 2026 |
| S & W (Group) Limited | Real estate | 2014 |
| S & W (Group) Properties Limited | Real estate | 2026 |
| S & W Design & Build (Group) Limited | Financial services | 2017 |
| S & W Process Engineering Limited | Manufacturing | 1984 |
| S G Miller Ltd | Manufacturing | 2021 |
| S J Wright Motors Limited | Wholesale & retail | 2010 |
| S V a Utilities Ltd | Real estate | 2024 |
| S.J. Surveying Services Ltd. | Professional & scientific | 2017 |
| Safe Secure Limited | Hospitality | 2024 |
| Safety First Training Limited | Administrative & support | 2016 |
| Sage Community CIC | Education | 2025 |
| Sage Education Provision Ltd | Education | 2024 |
| Sailrace Limited | Administrative & support | 2018 |
| SAM Harnett Ltd | Construction | 2025 |
| Sam's Bridal Boutique Ltd | Wholesale & retail | 2020 |
| Saminlu Ltd | Professional & scientific | 2022 |
| Saucer on the Hill Ltd | Manufacturing | 2021 |
| SB Cybersecurity Ltd | Information & communication | 2023 |
| Scarllet Kingsley Ltd | Wholesale & retail | 2015 |
| Schema Construction Services Limited | Administrative & support | 2024 |
| Scopetec Limited | Manufacturing | 2001 |
| Scout Intelligent Ltd | Wholesale & retail | 2020 |
| Scribe Engineering Limited | Professional & scientific | 2014 |
| SDR Tech Ltd | Wholesale & retail | 2021 |
| Sea SE Holding Ltd | Financial services | 2024 |
| Sea Structural Engineers Limited | Professional & scientific | 2017 |
| Sears Bros. Limited | Agriculture & fishing | 1944 |
| Seawave Services Limited | Transport & logistics | 2024 |
| SEE Fit Consulting Ltd | Professional & scientific | 2012 |
| Seedz Ltd | Wholesale & retail | 2023 |
| Selby & Taylor (Opticians) Limited | Health & social care | 2008 |
| Septdeux Ltd | Information & communication | 2025 |
| Sereen Nails & Beauty Limited | Other services | 2021 |
| SG Consulting + Planning Limited | Construction | 2003 |
| Shaping Behaviour Ltd | Other services | 2021 |
| Shaun Amps Plumbing & Heating Limited | Construction | 2008 |
| Shaun Amps Rentals Limited | Real estate | 2021 |
| Shgm Ltd | Other services | 2026 |
| Shift Sync Limited | Manufacturing | 2018 |
| Shine Cars Ltd | Transport & logistics | 2023 |
| Shinsen Limited | Hospitality | 2012 |
| Shire Homes & Building Services Ltd | Real estate | 2011 |
| Shire Homes Residents Hollow Road Ltd | Households | 2018 |
| Sialyork Ltd | Wholesale & retail | 2025 |
| Silver Hill in Notting Hill Limited | Wholesale & retail | 2022 |
| Siman Music Management Ltd | Arts & recreation | 2020 |
| Simply Reborn Limited | Manufacturing | 2008 |
| SJB Safety Ltd | Construction | 2022 |
| SJG Property Development & Investment Limited | Real estate | 2017 |
| Skribane Ltd | Wholesale & retail | 2022 |
| Skydive Chatteris Club Limited | Arts & recreation | 2013 |
| Skylark Garden Centre Limited | Wholesale & retail | 2003 |
| SLS Industrial Ltd | Manufacturing | 2026 |
| SLT Accountancy Ltd | Professional & scientific | 2026 |
| Smartnest Holdings Ltd | Real estate | 2024 |
| Smith-Wells Pubs Ltd | Hospitality | 2025 |
| Sobius Development Ltd | Other services | 2014 |
| Software Project Solutions Limited | Information & communication | 2006 |
| Sol-Gi Ltd | Extraterritorial | 2025 |
| Solar Gateway Ltd | Construction | 2017 |
| Solar Savings 4U Developments Limited | Construction | 2019 |
| Solar Savings 4U Limited | Real estate | 2011 |
| Solare Enterprises Limited | Administrative & support | 2018 |
| Sombrero Investments Ltd | Financial services | 2025 |
| Sosa’S House of Horror Ltd | Arts & recreation | 2025 |
| Specialised Bags Limited | Manufacturing | 2024 |
| Spice Valley Ltd | Hospitality | 2024 |
| Spot of Nature Ltd | Wholesale & retail | 2018 |
| Spotless Commercial Limited | Administrative & support | 2025 |
| Sprint 1124 Limited | Construction | 2006 |
| Spyder Tech RTK Ltd | Professional & scientific | 2023 |
| Squirrel Construction and Home Improvements Ltd | Construction | 2024 |
| ST. John's Chase (Freehold) Limited | Real estate | 2004 |