| Driven Futures CIC | Education | 2026 |
| Driven Minds CIC | Arts & recreation | 2024 |
| Driven Retreat Ltd | Wholesale & retail | 2025 |
| Drivenium Limited | Administrative & support | 2024 |
| Driver Crew Logistics Ltd | Transport & logistics | 2021 |
| Driver Delivery KVN Limited | Information & communication | 2025 |
| Driver Jobs Ltd | Administrative & support | 2025 |
| Driver Wise Ltd | Extraterritorial | 2022 |
| DRIVER4DRIVERS Recruitment Limited | Transport & logistics | 2013 |
| Drivergonomics Limited | Health & social care | 2025 |
| Drivers Only Club Ltd | Administrative & support | 2023 |
| Drives 4 U (North West) Ltd | Water & waste | 2021 |
| Drives to Success Driving School Manchester Ltd | Education | 2026 |
| Drivesq Ltd | Education | 2025 |
| Drivetime Rentals Ltd | Transport & logistics | 2023 |
| Driveto YOU Ltd | Other services | 2021 |
| Driveusuk Ltd | Administrative & support | 2021 |
| Drivevalia PVT Ltd | Wholesale & retail | 2026 |
| Driving Rite Ltd | Information & communication | 2022 |
| Driving Seat Group Limited | Financial services | 2020 |
| Drivr Ltd | Information & communication | 2019 |
| Drivv Limited | Administrative & support | 2024 |
| DRJ Medispa Ltd | Health & social care | 2026 |
| Drjoracosmeticos Ltd | Wholesale & retail | 2025 |
| Drkohli Limited | Health & social care | 2023 |
| Drmg Properties Limited | Real estate | 2025 |
| Drnalla Ltd | Education | 2022 |
| Drnco Limited | Administrative & support | 2026 |
| Dromos Mobility Limited | Transport & logistics | 2022 |
| Dronfield Estates Limited | Extraterritorial | 2020 |
| Dronfield Estates NO.2 Limited | Extraterritorial | 2026 |
| Dronsfield Holdings Limited | Real estate | 2018 |
| Droopy's Ventures Limited | Health & social care | 2023 |
| Drop a Gear Ltd | Wholesale & retail | 2026 |
| Drop BAG Global Limited | Wholesale & retail | 2018 |
| Drop City Ltd | Information & communication | 2011 |
| Drop Day Ltd | Professional & scientific | 2020 |
| Drop the Beet Ltd | Hospitality | 2020 |
| Dropco Ltd | Extraterritorial | 2023 |
| Dropout Market Limited | Wholesale & retail | 2025 |
| Droptoou Ltd | Wholesale & retail | 2024 |
| Dropvia Limited | Wholesale & retail | 2025 |
| Dropwear Limited | Wholesale & retail | 2025 |
| Drought Secret Ltd | Wholesale & retail | 2023 |
| Droylsden Appliances Ltd | Wholesale & retail | 2024 |
| Droylsden Bargain Limited | Wholesale & retail | 2025 |
| Droylsden Big Wash Ltd | Administrative & support | 2022 |
| Droylsden Discount Store Limited | Wholesale & retail | 2024 |
| Droylsden Engineering Services Ltd | Professional & scientific | 2019 |
| Droylsden Estate Elite Limited | Real estate | 2023 |
| Droylsden Glass Limited | Construction | 2010 |
| Droylsden Market Ltd | Wholesale & retail | 2025 |
| Droylsden OFF License Limited | Wholesale & retail | 2024 |
| Droylsden Road Management Co. Limited | Real estate | 2012 |
| Droylsden Training & Compliance Ltd | Administrative & support | 2026 |
| Droylsgin Limited | Manufacturing | 2020 |
| DRP Asset Management Limited | Real estate | 2022 |
| DRP Capital Ltd | Financial services | 2020 |
| DRP Truck Wash Ltd | Other services | 2015 |
| DRS CHA Ltd | Hospitality | 2022 |
| DRS Coldwell and Horrocks Ltd | Health & social care | 2026 |
| DRS Mclaren Limited | Health & social care | 2017 |
| DRS Mechanical Contractors Ltd | Construction | 2018 |
| DRS MH & SA Davies Ltd | Health & social care | 2016 |
| DRS Realisations Limited | Professional & scientific | 2001 |
| DRS16 Ltd | Construction | 2016 |
| Drsb Ltd | Health & social care | 2015 |
| Drsg Future Installations Ltd | Administrative & support | 2022 |
| Drsm Ltd | Financial services | 2023 |
| DRT Kitchens Limited | Construction | 2026 |
| DRT Manchester Ltd | Transport & logistics | 2026 |
| Drts Web Works Ltd | Information & communication | 2024 |
| DRU Sourcing Ltd | Households | 2025 |
| Drugasar Limited | Wholesale & retail | 1972 |
| Drum Roots Workshop Limited | Education | 2018 |
| Drum Therapy Collective CIC | Health & social care | 2024 |
| Drumacre Interiors Limited | Construction | 2025 |
| Drumacross Limited | Professional & scientific | 2018 |
| Drummond Ventures Ltd | Real estate | 2022 |
| Drummonds Limited | Financial services | 2004 |
| Drummonds of Manchester Limited | Construction | 1997 |
| Drumsilla Property Provision Ltd | Real estate | 2021 |
| Drunk Panda Ltd | Financial services | 2020 |
| Drushduds Ltd | Wholesale & retail | 2023 |
| Drvi Ltd | Information & communication | 2016 |
| DRW Property Management Ltd | Real estate | 2021 |
| DRY Developments Limited | Construction | 2023 |
| DRY Driveway Solution Ltd | Construction | 2024 |
| DRY Group Limited | Financial services | 2023 |
| DRY Properties Limited | Hospitality | 2016 |
| Dryday Damp Proofing Ltd | Construction | 2025 |
| Drydry Ltd | Construction | 2025 |
| Drying Ground Residents Limited | Real estate | 1996 |
| Drylining Management Ltd | Construction | 2025 |
| Drylining Standard Ltd | Construction | 2025 |
| Dryroof Services Limited | Construction | 2015 |
| Dryview Ltd | Real estate | 2023 |
| DS & AS Investments Limited | Real estate | 2009 |
| DS & SON Ltd | Transport & logistics | 2017 |
| DS and JP Holdings Ltd | Real estate | 2025 |