| Dirty Northern Town Limited | Manufacturing | 2014 |
| Dirty Old Town UK. Ltd. | Administrative & support | 2026 |
| Dirty Rascals Ltd | Hospitality | 2009 |
| DIS Independent Financial Planning Limited | Financial services | 2012 |
| Disa DOO Ltd. | Other services | 2025 |
| Disability Enterprise Ltd | Health & social care | 2020 |
| Disabled Living | Health & social care | 1943 |
| Disabled Living (Training & Exhibitions) Limited | Administrative & support | 2009 |
| Disarm Corporation Ltd | Professional & scientific | 2025 |
| Disassemble.App Ltd | Professional & scientific | 2018 |
| Disbelieved Apparel Limited | Wholesale & retail | 2024 |
| Discern Software Limited | Information & communication | 2018 |
| Disco Puss Ltd | Arts & recreation | 2023 |
| Discofan Ltd | Wholesale & retail | 2022 |
| Discount Artificial Grass Ltd | Other services | 2020 |
| Discount Daves Carpets Limited | Wholesale & retail | 2015 |
| Discount Distribution Ltd | Wholesale & retail | 2025 |
| Discount Furniture Warehouse Ltd | Wholesale & retail | 2018 |
| Discount House Electronic UK Limited | Wholesale & retail | 2023 |
| Discount House UK Ltd | Other services | 2018 |
| Discount Hub Gorton Ltd | Wholesale & retail | 2023 |
| Discount HUT Ltd | Wholesale & retail | 2024 |
| Discount Locker Ltd | Wholesale & retail | 2024 |
| Discount Mania Ltd | Wholesale & retail | 2024 |
| Discount Masters Ltd | Wholesale & retail | 2019 |
| Discount Paradize Ltd | Wholesale & retail | 2025 |
| Discount Sales Online Ltd | Wholesale & retail | 2021 |
| Discount Sportswear Ltd | Wholesale & retail | 2019 |
| Discount Wallpapers Limited | Wholesale & retail | 1993 |
| Discounted Plastics Holdings Limited | Professional & scientific | 2019 |
| Discounted Stores Limited | Real estate | 2019 |
| Discounted Ticket Limited | Wholesale & retail | 2025 |
| Discover Enneagram Ltd | Professional & scientific | 2026 |
| Discover Mortgage Ltd | Financial services | 2023 |
| Discoverend Group Ltd | Construction | 2025 |
| Discoverer Computing Ltd | Information & communication | 1999 |
| Discovery Acquisitions Limited | Administrative & support | 2018 |
| Discovery Legend Company Limited | Real estate | 2020 |
| Discreteheat Distribution Limited | Extraterritorial | 2013 |
| Diseno Forever Ltd | Wholesale & retail | 2022 |
| Disgital Ltd | Wholesale & retail | 2026 |
| Dish and Spoon Food Limited | Hospitality | 2014 |
| Dish Corporate Catering Limited | Hospitality | 2025 |
| Dish Events and Catering Limited | Hospitality | 2025 |
| Disha Homes Ltd | Real estate | 2024 |
| Disk Medical Services Limited | Health & social care | 2020 |
| Disley Trading Subsidiary Limited | Administrative & support | 2020 |
| Disleytrader Ltd | Professional & scientific | 2024 |
| Dispatch Out.Com Ltd | Administrative & support | 2025 |
| Display Sales Consulting Ltd | Administrative & support | 2023 |
| Disposables Direct Manchester Ltd | Wholesale & retail | 2005 |
| Disrepair Surveyors Limited | Professional & scientific | 2025 |
| Disruptr Resilience Ltd | Professional & scientific | 2026 |
| Distant Properties Limited | Real estate | 2005 |
| Distinct Consultancy Group Ltd | Administrative & support | 2021 |
| Distinct Vibes Ltd | Wholesale & retail | 2025 |
| Distinction Performance Wear Limited | Wholesale & retail | 2026 |
| Distinction Wrapping Ltd | Construction | 2024 |
| Distinctive Trading Ltd | Wholesale & retail | 2012 |
| Distinctly Aware Limited | Arts & recreation | 2016 |
| Distinguished Creative Masterpieces for Investment Ltd | Wholesale & retail | 2026 |
| Distinguished KID for Learning and Training Ltd | Other services | 2024 |
| Distort Ltd | Information & communication | 2026 |
| Distract Space Ltd | Other services | 2014 |
| Distrelec Ltd | Wholesale & retail | 2017 |
| Distribution Finance Capital Holdings PLC | Professional & scientific | 2019 |
| District 101 Ltd | Professional & scientific | 2025 |
| District 28 Software Ltd | Information & communication | 2022 |
| District Travel Ltd | Administrative & support | 2023 |
| DISTRICT29 Ltd | Hospitality | 2026 |
| Disxplne Ltd | Wholesale & retail | 2021 |
| Dita Estates Ltd | Real estate | 2025 |
| Dita Innovations Limited | Information & communication | 2025 |
| Dita Living Ltd | Wholesale & retail | 2020 |
| Dithio Ltd | Professional & scientific | 2019 |
| Dito Services Limited | Information & communication | 2012 |
| Ditta Medical Ltd | Health & social care | 2012 |
| Diunw Ltd | Administrative & support | 2022 |
| Diva Fashions (Manchester) Limited | | 2006 |
| Diva Gemstone Limited | Real estate | 2026 |
| Diva Interiors Limited | Wholesale & retail | 2022 |
| Diva International Ltd | Wholesale & retail | 2020 |
| Diva Ladies LOW Cost Limited | Wholesale & retail | 2017 |
| Divachic Ltd | Wholesale & retail | 2024 |
| Divak Ltd | Construction | 2022 |
| Divas World Limited | Wholesale & retail | 2019 |
| Divbracket Ltd | Information & communication | 2026 |
| Dive & Deep Ltd | Hospitality | 2024 |
| Dive Bar Concept Ltd | Hospitality | 2015 |
| Dive Manchester Ltd | Arts & recreation | 2017 |
| Diveco Innovations Limited | Wholesale & retail | 2025 |
| Divelifeuk Ltd | Administrative & support | 2017 |
| Divergent UK Operations Ltd | Information & communication | 2013 |
| Diverse and Equal Ltd | Administrative & support | 2018 |
| Diverse Healthcare Ltd | Health & social care | 2022 |
| Diverse Integrated Solutions Ltd | Other services | 2009 |
| Diverse Metric Ltd | Administrative & support | 2020 |
| Diverse North Services Ltd | Health & social care | 2025 |
| Diverse Security Ltd | Professional & scientific | 2006 |
| Diverse Stars for Trading and Investment Ltd | Wholesale & retail | 2025 |