| Sandcat Technologies Limited | Administrative & support | 2016 |
| Sandsbyte Limited | Information & communication | 2021 |
| Sanskaari Designs Limited | Wholesale & retail | 2004 |
| Sansome Properties Limited | Real estate | 2001 |
| Sant' Elia Limited | Agriculture & fishing | 2013 |
| Sara Bhavani Ltd | Information & communication | 2025 |
| Sara DA Silva Limited | Wholesale & retail | 2015 |
| Sarah Emily Destinations Limited | Administrative & support | 2025 |
| Sarah Harvey Speck Consulting Ltd | Professional & scientific | 2006 |
| Sarah-Jane`S Interiors Limited | Wholesale & retail | 2003 |
| Sarik Hobbies Limited | Manufacturing | 1997 |
| Savage Cabbage Ltd | Wholesale & retail | 2016 |
| SB Properties (Wales) Limited | Real estate | 2003 |
| Sbgg Limited | Financial services | 2016 |
| SC & JB Consultancy Limited | Professional & scientific | 2025 |
| Scalably Ltd | Information & communication | 2021 |
| Scaled Development Ltd | Administrative & support | 2002 |
| Schmersal Limited | Wholesale & retail | 1997 |
| Schmidt&Co Limited | Professional & scientific | 2019 |
| Scisco Investigative and Legal Training Ltd | Education | 2022 |
| Scot' House Management Company Limited | Households | 2020 |
| Scott Evans Consulting Ltd | Information & communication | 2024 |
| Scout Yourself Ltd | Education | 2023 |
| Sean Jones Wealth Management Limited | Financial services | 2009 |
| Seaspell Management Company Ltd | Real estate | 2014 |
| Secret Bolthole Ltd | Hospitality | 2026 |
| Secure Food Services Limited | Professional & scientific | 2019 |
| Secure Project Management Ltd | Professional & scientific | 2019 |
| Secureinc Limited | Information & communication | 2013 |
| Security Dialogues Limited | Professional & scientific | 2016 |
| Seed and Source Ltd | Wholesale & retail | 2022 |
| Seedtech Studios Ltd | Information & communication | 1987 |
| Selcouth Engineering Ltd | Manufacturing | 2015 |
| Select Research Ltd. | Professional & scientific | 1994 |
| Select Scanning Limited | Professional & scientific | 2006 |
| Self Creators Ltd | Health & social care | 2021 |
| Self Storage Worcester Ltd | Transport & logistics | 2025 |
| Sell Your House Fast Ltd | Real estate | 2024 |
| Sense Adventures Ltd | Administrative & support | 2021 |
| Sensory Software International Ltd | Information & communication | 1998 |
| Seosocial Ltd | Professional & scientific | 2022 |
| SERVCLEANING2YOU Limited | Administrative & support | 2025 |
| Setala Limited | Professional & scientific | 2020 |
| Seven Knights Consulting Limited | Professional & scientific | 2020 |
| Seven Property Management Limited | Real estate | 2014 |
| Severn Builders Ltd | Construction | 2025 |
| Severn Fulfilment Ltd | Administrative & support | 2026 |
| Severn Packaging Ltd | Administrative & support | 2023 |
| Seward Joinery Limited | Construction | 2018 |
| SGA Group (Pershore) Limited | Professional & scientific | 2006 |
| SGA Project & Cost Management Limited | Administrative & support | 1999 |
| Shanti Shanti (Ledbury) Limited | Wholesale & retail | 2010 |
| Sharing Time Ltd | Information & communication | 2025 |
| Shaun Morris Builders Ltd | Construction | 2009 |
| Shaun's Tyres Limited | Wholesale & retail | 2014 |
| Shazzja Ltd | Real estate | 2026 |
| Sheppard Building and Project Consultancy Limited | Professional & scientific | 2010 |
| Sherlock Homes Developments Limited | Construction | 1999 |
| Shernacre Limited | Real estate | 2026 |
| Sherr Online Ltd | Health & social care | 2025 |
| Sherriff Street Garage Limited | Wholesale & retail | 2018 |
| Shifting Moon Limited | Professional & scientific | 2015 |
| Shining Star Home Care Limited | Health & social care | 2020 |
| Shining Stars Nursery & Preschool Ltd | Education | 2019 |
| Shire Property Surveys Limited | Professional & scientific | 2021 |
| Shires Group Limited | Hospitality | 2024 |
| Shon Enterprises Ltd | Wholesale & retail | 2023 |
| Shotover Ltd | Other services | 2026 |
| Show SIU SIU Ltd | Real estate | 2024 |
| Show UP Limited | Professional & scientific | 2013 |
| Shrawbeth Ltd | Hospitality | 2019 |
| Shuttersphere Ltd | Professional & scientific | 2014 |
| Sidbury House Management Company Limited | Households | 2000 |
| Sidmouth House Limited | Real estate | 1979 |
| Sight Designs Ltd. | Manufacturing | 1997 |
| Signature Assignments Ltd | Information & communication | 2014 |
| SIGNATURE86 Limited | Professional & scientific | 2008 |
| Silver Works Ltd | Information & communication | 2011 |
| Silverdawn Limited | Information & communication | 2017 |
| Silverdawn Software Limited | Information & communication | 2017 |
| Simon Child Associates Limited | Professional & scientific | 2010 |
| Simon Hughes Advisory Limited | Professional & scientific | 2021 |
| Simon Lewis IPI Ltd | Information & communication | 2012 |
| Simovate Limited | Information & communication | 2020 |
| Simpson Farm Partners Limited | Agriculture & fishing | 2012 |
| Simson Aggregate Solutions Ltd | Wholesale & retail | 2021 |
| Sinton WR13 Limited | Hospitality | 2025 |
| Sisuti Limited | Professional & scientific | 2014 |
| Site Mechanical Support Limited | Manufacturing | 2014 |
| Site Solutions (BW) Limited | Water & waste | 2009 |
| Site Solutions (FM) Limited | Construction | 2017 |
| Sixtier Limited | Real estate | 2023 |
| SJ & JW Evans Limited | Wholesale & retail | 2003 |
| SJ Marchant Associates Limited | Professional & scientific | 2015 |
| SJP Ryland Ltd | Professional & scientific | 2018 |
| SJT Services (Malvern) Ltd | Transport & logistics | 2021 |
| Skara Tattoo Limited | Other services | 2018 |
| Skaro Ltd | Information & communication | 2016 |
| Skelton Young Ltd | Real estate | 2009 |
| Skills Voice Ltd | Education | 2026 |