| OUT of Town Artworker Limited | Professional & scientific | 2019 |
| Outdoor Games Company Ltd | Arts & recreation | 2025 |
| Overton Properties (Malpas) Limited | Professional & scientific | 2010 |
| PAH Systems Limited | Administrative & support | 2013 |
| Parkfields Foods Limited | Extraterritorial | 2003 |
| Paul Keeley Building Services Limited | Construction | 2014 |
| Paul Wynne Antiques Limited | Professional & scientific | 2002 |
| Payne Solutions UK Limited | Information & communication | 2025 |
| PD Craggs Ltd | Transport & logistics | 2021 |
| Pheasantsnye Holidays Ltd | Real estate | 2019 |
| Philip Proudlove & SON Limited | Manufacturing | 2009 |
| PHJ Property Limited | Real estate | 2016 |
| Pippa's Cleaning Services Ltd | Administrative & support | 2025 |
| PJW Trading Limited | Information & communication | 2016 |
| Plant & Robinson Construction Limited | Construction | 2014 |
| Poppy Permanent Makeup Artist Ltd | Other services | 2023 |
| Porterbrook Solutions Ltd | Professional & scientific | 2021 |
| POW Events Ltd | Other services | 2021 |
| Pratik Bhaii Ltd | Transport & logistics | 2025 |
| Preston Hall Farm Management Company Limited | Extraterritorial | 1997 |
| Professional Golf Accountant Ltd | Professional & scientific | 2026 |
| Puremedical (UK) Limited | Wholesale & retail | 2009 |
| Queens Road Property Management Limited | Households | 2001 |
| R J Spruce Limited | Construction | 2011 |
| Rachel Strong Interpreting Limited | Professional & scientific | 2024 |
| Rachel Wilkins BSL Interpreting Ltd | Professional & scientific | 2025 |
| Radero Limited | Real estate | 2013 |
| Rambl Outdoors Ltd | Wholesale & retail | 2021 |
| Really Engaging Marketing Ltd | Professional & scientific | 2026 |
| Red Lake Training Ltd | Professional & scientific | 2026 |
| Red LEG Consultancy Ltd | Professional & scientific | 2023 |
| Red RUM Racing Ltd | Arts & recreation | 1997 |
| Rejuvo Limited | Construction | 2006 |
| Rejuvo Products Ltd | Construction | 2006 |
| Repute Systems Limited | Professional & scientific | 2025 |
| Richmer Ltd | Real estate | 2018 |
| RME Cheshire Veterinary Services Ltd | Professional & scientific | 2024 |
| Robat Griffiths CYF | Agriculture & fishing | 2016 |
| ROE Products Limited | Manufacturing | 2014 |
| Rooted Signs Ltd | Professional & scientific | 2024 |
| Roshannah Phillips Interpreting Limited | Professional & scientific | 2019 |
| Rosto Trading Ltd | Hospitality | 2020 |
| RP Development Holdings Ltd | Financial services | 2021 |
| RPM Interpreting Services Ltd | Professional & scientific | 2025 |
| Rupert Gunstone Mrcvs Ltd. | Professional & scientific | 2015 |
| S. J. Hales Limited | Professional & scientific | 1999 |
| SAB Carpentry and Landscaping Ltd | Manufacturing | 2025 |
| Safeshade Limited | Manufacturing | 2025 |
| Safeworkuk Ltd | Professional & scientific | 2026 |
| Sandy Bears Nursery + PRE School Cholmondeley Ltd | Education | 2017 |
| Sanisen Ltd | Wholesale & retail | 2022 |
| Saratoga Holdings Ltd | Administrative & support | 2026 |
| Scott Cooper Construction Ltd | Administrative & support | 2022 |
| Sensor Security Holdings Ltd | Administrative & support | 2022 |
| SG Interpreting Limited | Health & social care | 2015 |
| Shajahan Indian Restaurant 37 Ltd | Hospitality | 2026 |
| Shajahan Indian Restaurant Ltd | Hospitality | 2024 |
| Shakti Shanti UK Limited | Wholesale & retail | 2017 |
| Signal Estates Limited | Real estate | 2017 |
| Silaba Crafts Ltd | Wholesale & retail | 2025 |
| Silver Lining Design and Build Ltd | Construction | 2024 |
| SJD Environmental Ltd | Water & waste | 2023 |
| SJS Biocommunications Ltd | Professional & scientific | 2020 |
| Smart Avionics Limited | Manufacturing | 2002 |
| Smith and Whiston Limited | Administrative & support | 2018 |
| Smithy Bank Management Company Limited | Households | 2004 |
| Sokasignlanguage Ltd | Professional & scientific | 2025 |
| Solo Movers Ltd | Transport & logistics | 2023 |
| Specs Consultancy Limited | Administrative & support | 2021 |
| SSM Investments Ltd | Professional & scientific | 2003 |
| Stable Door Ltd | Real estate | 2021 |
| Staged by Design Ltd | Professional & scientific | 2024 |
| Starsearch Developments Limited | Real estate | 1998 |
| Stockton Hall Farm Racing LLP | | 2021 |
| Strands Limited | Wholesale & retail | 1988 |
| Surface Technicians Ltd | Construction | 2012 |
| Sweetheart Productions Limited | Arts & recreation | 2003 |
| T & S Branch Limited | Wholesale & retail | 2017 |
| T S Pritchard Construction Ltd | Construction | 2024 |
| T Woodworth Ltd | Construction | 2022 |
| Tarfam Services Ltd | Administrative & support | 2013 |
| Technical Farm Services Limited | Agriculture & fishing | 2010 |
| Thanu Retail Limited | Wholesale & retail | 2016 |
| THE BIO Agents Ltd | Administrative & support | 2025 |
| THE Blue Event Group Ltd | Administrative & support | 2015 |
| THE Cheshire Wildlife Trust Limited | Professional & scientific | 1962 |
| THE Cholmondeley Pageant of Power Company Limited | Professional & scientific | 2007 |
| THE Crown Y Goron Limited | Hospitality | 2018 |
| THE Event Station Limited | Other services | 2012 |
| THE Farmers Field LLP | | 2020 |
| THE Hamptons Management Company Limited | Real estate | 2015 |
| THE Hough Development Management Company Limited | Households | 1998 |
| THE Long Barn S5 Holdings Limited | Financial services | 2026 |
| THE Lost Barn Ltd | Hospitality | 2024 |
| THE Paddocks Oldcastle Limited | Real estate | 2022 |
| THE Remarkable Bathroom Company Ltd | Wholesale & retail | 2018 |
| THE SMITH5 Limited | Extraterritorial | 2022 |
| THE Solutions Business (UK) Limited | Professional & scientific | 2006 |
| THE Tax Hive Limited | Professional & scientific | 2019 |
| Tikvah Doodles Ltd | Agriculture & fishing | 2014 |