| Deacons Martial Arts Lutterworth Ltd | Arts & recreation | 2024 |
| Deadpan Robot Ltd | Wholesale & retail | 2017 |
| Dealey Floor Preparation Limited | Construction | 2002 |
| Debdale Consultancy Limited | Professional & scientific | 1966 |
| Deborah Foong Limited | Health & social care | 2023 |
| Deer Close Management Company Limited | Households | 2016 |
| Delamata Ltd | Health & social care | 2016 |
| Deleso Limited | Professional & scientific | 2013 |
| Dell's FAB Ltd | Administrative & support | 2016 |
| Delvara Limited | Wholesale & retail | 1983 |
| Derby Access Scaffolding Ltd | Construction | 2017 |
| Design for Service Limited | Professional & scientific | 2007 |
| DESIGN4RETAIL Limited | Professional & scientific | 2002 |
| Detekt Ltd | Manufacturing | 2020 |
| Deti Ltd | Hospitality | 2023 |
| Development & Project Services (Southern) Ltd | Other services | 2013 |
| Devil's Peak Prop Ltd | Real estate | 2024 |
| DG Analytical Limited | Manufacturing | 2021 |
| DG Fencing Ltd | Construction | 2020 |
| Dhanvantri Healthcare Limited | Other services | 2019 |
| Dhanvantri Properties Limited | Real estate | 2011 |
| Diakosent Limited | Health & social care | 2023 |
| Diamond Fire Limited | Construction | 2000 |
| Dica Creative Ltd. | Professional & scientific | 2018 |
| Digital Advanced Control Limited | Manufacturing | 2009 |
| Digital Advanced Group Limited | Financial services | 2008 |
| Digital SEO Ltd | Information & communication | 2015 |
| Dignified Dining Limited | Professional & scientific | 2022 |
| Divorce Ltd | Professional & scientific | 2018 |
| DIY Done for YOU Ltd | Construction | 2022 |
| DJM Coaching & Consulting Limited | Administrative & support | 2019 |
| DK Autosolutions Ltd | Wholesale & retail | 2025 |
| Dlgn Limited | Professional & scientific | 1990 |
| DLP Design + Build Management Limited | Other services | 1983 |
| DLS Services (Leicester) Limited | Wholesale & retail | 2017 |
| DLZ Property Limited | Real estate | 2025 |
| DMB Homes Limited | Real estate | 2023 |
| Dmcuk Ltd | Transport & logistics | 2017 |
| DMH Building Contractors Ltd | Construction | 2016 |
| Dmlink Ltd | Administrative & support | 2009 |
| DO Differently Ltd | Professional & scientific | 2011 |
| Doft Limited | Financial services | 2015 |
| Doggy Swim & Splash Ltd | Other services | 2024 |
| Domi Digital Ltd | Information & communication | 2026 |
| DON Speake & Company Limited | Manufacturing | 1999 |
| Donaghy Restoration Ltd. | Construction | 2016 |
| Doodle Build Containers Ltd | Construction | 2019 |
| Doodle Build Ltd | Professional & scientific | 2016 |
| Dorset Property (Weymouth) Limited | Real estate | 2015 |
| Double Doodles Dog Care Limited | Other services | 2018 |
| Dovedata Limited | | 1979 |
| Dowbridge Investments Ltd | Real estate | 2023 |
| DR a Sriemevan Limited | Other services | 2009 |
| DR ALA Ltd | Health & social care | 2016 |
| DR Aparna Deshpande Ltd | Other services | 2014 |
| DR C Elton Ltd | Health & social care | 2016 |
| DR Iqbal Ltd | Other services | 2013 |
| DR J L Deloughry Anaesthetics Ltd | Health & social care | 2023 |
| DR Obloza's Rooms Ltd | Health & social care | 2021 |
| DR Olivia Barney Ltd | Health & social care | 2019 |
| DR P M Dalrymple Ltd | Other services | 2016 |
| DR R Mann Ltd | Health & social care | 2021 |
| DR003 Ltd | Administrative & support | 2023 |
| Dragonsticks Limited | Other services | 2009 |
| Draycote Technology Ltd | Manufacturing | 1989 |
| DRB Collection Ltd | Real estate | 2025 |
| Dream Express Ltd | Transport & logistics | 2021 |
| Dream-Ice Limited | Wholesale & retail | 2010 |
| Dreamfuel Films Ltd | Information & communication | 2024 |
| Drive on Time Limited | Extraterritorial | 2018 |
| Driven in Luxury Limited | Transport & logistics | 2017 |
| DRY Stone Walls Ltd | Construction | 2022 |
| DSA Leicester Limited | Information & communication | 2010 |
| DSH2 Limited | Real estate | 2024 |
| DSI Gastro Services Limited | Health & social care | 2024 |
| DSI2 Limited | Arts & recreation | 2022 |
| Dsjb Associates Ltd | Health & social care | 2006 |
| DT Central Limited | Construction | 2010 |
| DTB Motorsport Ltd | Wholesale & retail | 2018 |
| DTF Consultancy Limited | Hospitality | 2017 |
| DTM (Leicester) Limited | Administrative & support | 2010 |
| DTM Gardens & Landscapes Ltd | Construction | 2003 |
| Dudley Associates Limited | Manufacturing | 1990 |
| Dugmore Properties and Events Limited | Real estate | 2013 |
| Duke of UKE Limited | Wholesale & retail | 2005 |
| Dunton Bassett Cars Limited | Wholesale & retail | 2025 |
| Dunton Bassett Farms Ltd | Administrative & support | 2026 |
| Duracell E Charge Limited | Transport & logistics | 2025 |
| Dursleybull Ltd | Other services | 2013 |
| Durson Property Solutions Ltd | Real estate | 2024 |
| Durson Solutions Ltd | Hospitality | 2022 |
| Dusty Divas Cleaning Ltd | Administrative & support | 2026 |
| Dynamic Motion Detection Limited | Professional & scientific | 2011 |
| Dynamo Dents Limited | Wholesale & retail | 2018 |
| Dynodaze Performance Parts Ltd | Wholesale & retail | 2016 |
| E a Digital Limited | Manufacturing | 2011 |
| E Cowley Limited | Other services | 2010 |
| E&R Tearoom Ltd | Hospitality | 2019 |
| E.L. Cook Electrical Limited | | 1958 |
| EA Signs Ltd | Other services | 2009 |