| Soleil Salons Limited | Other services | 2023 |
| Solidground Build Services Ltd | Construction | 2026 |
| Something Holdings Ltd | Wholesale & retail | 2026 |
| Something Live Ltd | Wholesale & retail | 2026 |
| Something Organisation Ltd | Wholesale & retail | 2026 |
| Sonder Spirits Ltd | Manufacturing | 2025 |
| SOS Lettings Limited | Real estate | 2017 |
| South Kilworth Riding Club Ltd | Arts & recreation | 2008 |
| South Kilworth Road 2021 Management Company Ltd | Households | 2021 |
| Southern Bear Ltd. | Arts & recreation | 2014 |
| Southern Logic Limited | Information & communication | 1987 |
| Spark Strategy Ltd | Administrative & support | 2018 |
| Sparrow Hall Trading Limited | Real estate | 2002 |
| Speake Heating & Building Ltd | Construction | 2017 |
| Specialised Preparation and Finishing Limited | Manufacturing | 2017 |
| Specialist Flight Training Limited | Education | 2014 |
| Spectrum Estates & Property Management Ltd | Real estate | 2018 |
| Spectrum Ltd | Information & communication | 2016 |
| Sphere Logistics Consulting Ltd | Extraterritorial | 2023 |
| Spiers@Clipsham Limited | Professional & scientific | 2005 |
| SPIN7 Limited | Professional & scientific | 2022 |
| Spinneys Consulting Limited | Administrative & support | 2010 |
| Spoerry Consulting Ltd | Administrative & support | 2013 |
| Sportapply Limited | Wholesale & retail | 1996 |
| Sprayhub Ltd | Construction | 2020 |
| Squires of Southwold Ltd | Wholesale & retail | 2021 |
| SRJ Car and Commercial Repairs Ltd | Wholesale & retail | 2025 |
| Srsl Holdings Ltd | Financial services | 2019 |
| Ssmk Dulloo Limited | Health & social care | 2023 |
| ST Johns Road Dental Practice (Leicester) Limited | Health & social care | 2020 |
| ST Johns Road Medical Practice Limited | Health & social care | 2019 |
| Stable Hands Equine Massage Ltd | Agriculture & fishing | 2023 |
| Stack Zero Limited | Administrative & support | 2015 |
| STAFF4YOU Ltd | Administrative & support | 2025 |
| Staffbase Recruitment Limited | Administrative & support | 2014 |
| Starlite Properties Ltd | Real estate | 2020 |
| Stemma Ventures Ltd | Financial services | 2025 |
| Stephenson Medical Services Ltd | Health & social care | 2018 |
| Stewart Quality Engineering Ltd | Professional & scientific | 2018 |
| Sticks Meadows Ltd | Other services | 2022 |
| Stinkysaurus Limited | Professional & scientific | 2007 |
| Stjohn Krog Enterprises Limited | Professional & scientific | 2026 |
| Stockport Power Tools Limited | Professional & scientific | 1996 |
| Stodola Consulting Ltd | Professional & scientific | 2020 |
| Stomp Digital Ltd | Professional & scientific | 2022 |
| Stonepave UK Limited | Wholesale & retail | 2000 |
| Stretch Electrical Limited | Construction | 2012 |
| Strong O'Meara Limited | Construction | 2003 |
| Studio Admire Ltd | Information & communication | 2018 |
| Studio Figura London TW7 Ltd | Health & social care | 2014 |
| Studio Figura UK Brand Ltd | Administrative & support | 2019 |
| Studio Jaine Limited | Professional & scientific | 2012 |
| Stylish Living Group Limited | Real estate | 2020 |
| Sublime Binary Limited | Information & communication | 2015 |
| Summers Associates Limited | Professional & scientific | 2014 |
| Summit Direct Solutions Ltd | Administrative & support | 2019 |
| Summit Scaffold Solutions Limited | Construction | 2017 |
| Sun Imaging Limited | Health & social care | 2010 |
| Sunkart IND Prativik Ltd | Health & social care | 2023 |
| Sunningdale Timber (Mouldings) Ltd | Manufacturing | 2009 |
| Superbo Limited | Professional & scientific | 2018 |
| Suresafe Technical Limited | Administrative & support | 2009 |
| Suryadeep Ltd | Other services | 2014 |
| Susan Burgin Limited | Administrative & support | 2004 |
| SW Precision Engineering Ltd | Manufacturing | 2025 |
| Swan & Co Ltd | Other services | 2014 |
| Swanline Paper & Board Limited | Manufacturing | 2017 |
| Swarna Limited | Real estate | 2021 |
| Sweet Desires (UK) Limited | Manufacturing | 2017 |
| Sweet Retreat Wholesale Limited | Wholesale & retail | 2023 |
| Sweet Sisters Sweet Shop Ltd | Wholesale & retail | 2022 |
| Swift Energy Consultants Limited | Wholesale & retail | 2009 |
| Swift Flash Limited | Administrative & support | 2018 |
| SY ENG Ltd | Professional & scientific | 2020 |
| Syentra Consultancy Limited | Information & communication | 2026 |
| Synergy Healthcare Partnerships Ltd | Health & social care | 2021 |
| Synergy in Trade Consultancy LLP | | 2013 |
| Synergy in Trade Ltd | Financial services | 2007 |
| Synogram Ltd | Information & communication | 2008 |
| Synsent Ltd | Information & communication | 2022 |
| Szekler Ltd | Transport & logistics | 2022 |
| T & M Developments Midlands Ltd | Construction | 2020 |
| T & T Construction (Coalville) Limited | Other services | 2011 |
| T & W Construction Solutions Ltd | Construction | 2019 |
| T Bayliff Consulting Ltd | Professional & scientific | 2013 |
| T H B Monitoring Ltd | Professional & scientific | 2022 |
| T R L Commercials Limited | Transport & logistics | 1998 |
| T S Components Ltd | Wholesale & retail | 2009 |
| T S Home Improvements Limited | Other services | 2004 |
| T. MAC Enterprises Limited | Information & communication | 1997 |
| T.R.F. Moulds & Joinery Limited | Manufacturing | 2008 |
| T.Rudkin Air Conditioning Services Ltd | Energy | 2023 |
| Tablind Limited | Health & social care | 2019 |
| Tailored Grain Ltd | Manufacturing | 2020 |
| Talbot Dreams Limited | Real estate | 2024 |
| Talentorder Limited | Administrative & support | 2018 |
| Tanish Off-Licence Ltd | Wholesale & retail | 2025 |
| Tasktrack Limited | Professional & scientific | 2025 |
| Tate Rowlands Ltd | Real estate | 2015 |
| Taylor's Groundworks Limited | Other services | 2009 |