| Empire Petroleum Ltd | Administrative & support | 2011 |
| Empire Scaffolding Group Ltd | Construction | 2016 |
| Emporiom Store Ltd | Wholesale & retail | 2026 |
| Emporium Embroidery Ltd | Manufacturing | 2019 |
| Emporium Mart Ltd | Wholesale & retail | 2025 |
| Empowera Ltd | Health & social care | 2022 |
| Empowering Education C.I.C. | Education | 2017 |
| Empowering Minds Coaching Ltd | Health & social care | 2023 |
| Empowering Women CIC | Education | 2024 |
| Empray Limited | Administrative & support | 2025 |
| Emran Enterprise Ltd | Hospitality | 2014 |
| Emron Properties Limited | Real estate | 2020 |
| EMS Aesthetics Ltd | Other services | 2026 |
| EMS Incorporated Limited | Energy | 2026 |
| EMS Letting Solutions Limited | Real estate | 2007 |
| Emsrayne Limited | Construction | 1992 |
| Emy&B Ltd | Transport & logistics | 2016 |
| Enabling Care Services Ltd | Health & social care | 2020 |
| ENB Tiling Limited | Construction | 2022 |
| Enbrook Construction Ltd | Construction | 2013 |
| Enchanted Magic Mirror Ltd | Other services | 2018 |
| Encore Machinery Limited | Manufacturing | 2001 |
| Encore Machines Limited | Financial services | 2016 |
| Encore Prod Limited | Information & communication | 2025 |
| Encryptus Limited | Financial services | 2020 |
| END Property Limited | Wholesale & retail | 2018 |
| Endcroft Property Limited | Construction | 2014 |
| Endeavour Assets Ltd | Real estate | 2017 |
| Endeavour Care Limited | Health & social care | 2024 |
| Endurance Solutions Ltd | Information & communication | 2018 |
| Enduring Care Limited | Administrative & support | 2023 |
| Endymion Investments Limited | Real estate | 2017 |
| Endz Autos Ltd | Wholesale & retail | 2026 |
| Enerco Doors & Loading Bay Solutions Limited | Wholesale & retail | 2000 |
| Enerco Doors Holdings Ltd | Financial services | 2013 |
| Enerco Properties Limited | Real estate | 2017 |
| Energent Ltd | Construction | 2025 |
| Energy Care Holdings Limited | Real estate | 2022 |
| Energy Efficient Limited | Construction | 2025 |
| Energy Engineering - UK & Europe Ltd | Professional & scientific | 2020 |
| Energy FIX Limited | Construction | 2022 |
| Energy Green Insulation Limited | Construction | 2018 |
| Energy Solution Essex Ltd. | Transport & logistics | 2014 |
| Energybot Limited | Other services | 2024 |
| Enerj Smart Ltd | Wholesale & retail | 2017 |
| ENF Homes Ltd | Real estate | 2024 |
| Enfenete Energy Solutions Ltd | Other services | 2015 |
| Enfria Ltd | Wholesale & retail | 2019 |
| Engb Ltd | Transport & logistics | 2015 |
| Engims Ltd | Professional & scientific | 2020 |
| Engine HQ Limited | Manufacturing | 2018 |
| Engineering Compliance Group Ltd | Professional & scientific | 2025 |
| Engineers Consulting Limited | Professional & scientific | 2012 |
| Engiwise Ltd | Construction | 2018 |
| Enhanced Brows & Beauty Bedfordshire Ltd | Other services | 2017 |
| Enhanced Consulting Limited | Professional & scientific | 2013 |
| ENI Ltd UK Ltd | Extraterritorial | 2025 |
| Enigma Enterprise Limited | Administrative & support | 2021 |
| Enisco Ltd | Financial services | 2017 |
| ENK Couriers Ltd | Transport & logistics | 2018 |
| Enlent Ltd | Information & communication | 2026 |
| ENN Projects Limited | Administrative & support | 2015 |
| Enroute Education Services Limited | Education | 2023 |
| Entech Consultancy Ltd | Information & communication | 2016 |
| Entegra Limited | Administrative & support | 2013 |
| Enter REG Limited | Information & communication | 2021 |
| Enterprise Energy Solutions Ltd | Professional & scientific | 2018 |
| Enterprise Integrated Solutions Limited | Construction | 2010 |
| Enterprise Optical Limited | Health & social care | 2006 |
| Enterprise Systems Advisors UK Ltd | Information & communication | 2023 |
| Enterprise Unified Consultancy Ltd | Information & communication | 2023 |
| Entrust Business Services Limited | Information & communication | 2013 |
| ENV Capital Ltd | Financial services | 2025 |
| Enven Limited | Professional & scientific | 2017 |
| Enviable Occasions Ltd | Hospitality | 2025 |
| Envira Investments Limited | Financial services | 2013 |
| Envira Limited | Water & waste | 2001 |
| Envira Packaging Ltd | Administrative & support | 2008 |
| Envira Property Limited | Financial services | 2013 |
| Envira Waste Services Limited | Professional & scientific | 2014 |
| Enviro Cleaning Supplies Ltd | Wholesale & retail | 2012 |
| Enzo Traders Limited | Transport & logistics | 2006 |
| Enzo's Auto Deals Ltd | Wholesale & retail | 2024 |
| Enzoroy Construction Services Ltd | Administrative & support | 2025 |
| Enzose Ltd | Construction | 2025 |
| EON Global Services Ltd | Wholesale & retail | 2016 |
| EP Capital Holdings Ltd | Real estate | 2021 |
| EP Commercial Ltd | Real estate | 2024 |
| EP Couriers Ltd | Transport & logistics | 2018 |
| EP Electrical & Mechanical Services Limited | Construction | 2017 |
| EP HCW Ltd | Wholesale & retail | 2023 |
| EP Property Holdings Ltd | Real estate | 2023 |
| EPC GAS Specialist Ltd | Administrative & support | 2021 |
| EPC Specialist Luton Ltd | Construction | 2023 |
| Epexcart Ltd | Wholesale & retail | 2026 |
| Ephraim and Sons . Ltd | Health & social care | 2022 |
| Epic Deals (UK) Limited | Wholesale & retail | 2022 |
| Epic Equip Ltd. | Other services | 2021 |
| Epic Luton Parent Carer Forum CIC | Information & communication | 2023 |
| Epic Malabari Limited | Administrative & support | 2025 |