| Sco-Comm Limited | Information & communication | 2006 |
| Scolaris Elite Group Ltd | Education | 2024 |
| Scooby K9 Limited | Other services | 2021 |
| Scope Events Ltd | Administrative & support | 2022 |
| Scopemajor Exhibitions Limited | Professional & scientific | 1993 |
| SCORPIO786 Limited | Wholesale & retail | 2026 |
| Scos Smart Homes Limited | Real estate | 2022 |
| Scott & Turner Limited | Real estate | 2019 |
| Scott Riddoch Digital Ltd | Information & communication | 2022 |
| Scott Taylor Movemore Ltd | Health & social care | 2026 |
| Scottj Engineering Ltd | Professional & scientific | 2025 |
| Scotty's Travel Ltd | Administrative & support | 2025 |
| SCR Mechanical Services Limited | Administrative & support | 2013 |
| Screening and Vetting Limited | Information & communication | 2026 |
| Scuff 'N' Chips Ltd | Wholesale & retail | 2009 |
| Scullion Consulting Ltd | Professional & scientific | 2019 |
| Sculpt Pilates Ltd | Health & social care | 2022 |
| Sculptwithsherree Ltd | Other services | 2026 |
| Scuzzy Limited | Hospitality | 2025 |
| SD Medical Limited | Health & social care | 2023 |
| SD Uddin Limited | Hospitality | 2019 |
| SDC Healthcare Services Limited | Health & social care | 2025 |
| SDC Motor Consultants Ltd | Administrative & support | 2026 |
| SDC Motor Trade Ltd | Wholesale & retail | 2026 |
| SDC Real Estate Ltd | Real estate | 2025 |
| SDE Environmental Limited | Extraterritorial | 2008 |
| SDE Holdings Limited | Extraterritorial | 2008 |
| SDHB110 Ltd | Health & social care | 2018 |
| SDL (Sundon) Limited | Construction | 2014 |
| SDL Drylining Limited | Construction | 2020 |
| SDL7 Limited | Real estate | 2021 |
| SDM Healthcare Limited | Extraterritorial | 2016 |
| Sdvs Electrical Ltd | Construction | 2021 |
| SDW3 Ltd | Administrative & support | 2016 |
| SDZ Care Limited | Health & social care | 2022 |
| Sea Villa Ltd | Hospitality | 2019 |
| Seab Independent Services Ltd | Health & social care | 2026 |
| Seabel Ltd | Wholesale & retail | 2013 |
| Seamless Cargo Limited | Transport & logistics | 2024 |
| Seamless Solutions Ltd | Professional & scientific | 2024 |
| Sean Wood Consulting Limited | Information & communication | 2025 |
| Seastrand Limited | Wholesale & retail | 2026 |
| Seath Services Ltd | Construction | 2021 |
| Seaxes Travel Limited | Transport & logistics | 2013 |
| SEB Building Ltd | Construction | 2018 |
| SEB Landscaping Limited | Administrative & support | 2024 |
| SEB UK Transport Limited | Transport & logistics | 2022 |
| Seba Care Services UK Limited | Health & social care | 2023 |
| Sebastian GAS Services Limited | Professional & scientific | 2015 |
| Sebb Ltd. | Wholesale & retail | 2013 |
| Seby Decoration Ltd | Construction | 2025 |
| Sebzz Electrics Limited | Construction | 2024 |
| Secit Infrastructure Limited | Information & communication | 2009 |
| Second Life Refinishing Ltd | Construction | 2024 |
| Secretangels Integrated Care & Community Support Services Ltd | Public administration | 2018 |
| Secrets (Euston) Ltd | Other services | 2001 |
| Secular Property Solutions Limited Liability Partnership | | 2022 |
| Secur Global Limited | Wholesale & retail | 2012 |
| Secure Community Services Limited | Administrative & support | 2020 |
| Secure House Ltd | Administrative & support | 2015 |
| Secure K9 Limited | Administrative & support | 2026 |
| Secure Link Holdings Limited | Financial services | 2023 |
| Secure Link Security Limited | Administrative & support | 2025 |
| Secure Networking Solutions Ltd | Information & communication | 2010 |
| Secure Security Lifesafety Systems Ltd | Administrative & support | 2020 |
| Secure Security Services Ltd | Administrative & support | 2020 |
| Secure Tax Centre Ltd | Professional & scientific | 2018 |
| SECURE2STAFF Ltd | Financial services | 2024 |
| Secured Asset Services Limited | Administrative & support | 2022 |
| Secureroute Visa Services Ltd | Administrative & support | 2026 |
| Securiteam Limited | Administrative & support | 2021 |
| Security Training Solutions Ltd | Other services | 2012 |
| Seduire London Beauty Clinic Limited | Other services | 2013 |
| Seduire Property Limited | Real estate | 2018 |
| Seedling Insights & Strategy Limited | Professional & scientific | 2020 |
| Seensave Ltd | Wholesale & retail | 2024 |
| Seerat Construction Limited | Construction | 2025 |
| Segconstruct Ltd | Construction | 2025 |
| Sege to Grace Limited | Public administration | 2019 |
| Segula Technologies Limited | Professional & scientific | 2003 |
| Segur Limited | Construction | 2014 |
| Sehaj Construction Services Ltd | Construction | 2023 |
| Sehamuddin Ltd | Wholesale & retail | 2025 |
| Sehri Holdings Ltd | Financial services | 2025 |
| Sehri Properties Ltd | Real estate | 2023 |
| Seht Limited | Manufacturing | 2012 |
| Sein Holdings Ltd | Real estate | 2022 |
| Sein Services Ltd | Transport & logistics | 2020 |
| Sejkin Limited | Wholesale & retail | 2024 |
| Sekanda Nasar Consulting Ltd | Financial services | 2025 |
| Seke IT Solutions Ltd | Information & communication | 2025 |
| Selbourne Storage Ltd. | Transport & logistics | 2017 |
| Select a Services Limited | Administrative & support | 2021 |
| Select Dream Car Limited | Wholesale & retail | 2024 |
| Select SK Ltd | Professional & scientific | 2020 |
| Select Sports Limited | Arts & recreation | 2013 |
| Self Driven Couriers Limited | Transport & logistics | 2018 |
| Self Hire Retail Ltd | Other services | 2025 |
| Self Reliant Limited | Information & communication | 2026 |
| Self-Uk C.I.C. | Information & communication | 2022 |