| D.C. and C.P. Myers Limited | Real estate | 1998 |
| D.M. Hewson Joinery Limited | Construction | 2002 |
| D.U.A Inclusive Education Consultancy Ltd | Education | 2024 |
| D2CLEAN - Cleaning Services Ltd | Administrative & support | 2022 |
| D4S Partnership Limited | Education | 2024 |
| DA Industries Limited | Wholesale & retail | 2019 |
| DAB Premium Homes Ltd | Real estate | 2025 |
| Damselfly Living Limited | Wholesale & retail | 2012 |
| Dana Homes Ltd | Real estate | 2002 |
| Daniel Crane Sporting Art Limited | Arts & recreation | 2003 |
| Dark Armour (International) Limited | Professional & scientific | 2023 |
| Dark Armour (UK) Limited | Professional & scientific | 2023 |
| Dark Armour Ltd | Administrative & support | 2017 |
| Dave Skells Traffic Management Ltd | Professional & scientific | 2011 |
| Dave Ward Builders Limited | Construction | 2020 |
| Davey Close Limited | Other services | 2004 |
| David Blakey Vehicle Repairs Ltd | Other services | 2003 |
| David Elston Associates Limited | Education | 2014 |
| DAVIESGLENN2 Ltd | Professional & scientific | 2023 |
| DC Nail Bar Limited | Other services | 2021 |
| Deedar Express Ltd | Hospitality | 2025 |
| Deedar Louth Ltd | Hospitality | 2023 |
| Deedar Spice Ltd | Hospitality | 2026 |
| Delicious Happiness Limited | Manufacturing | 2024 |
| Denby Forestry Limited | Real estate | 2021 |
| Denby Trawlers Limited | Financial services | 1973 |
| Denniss & Marwood Developments Limited | Construction | 1988 |
| Designqube by Steven Brown Limited | Professional & scientific | 2006 |
| Destiny Reading’S Ltd | Arts & recreation | 2022 |
| Diesequip Ltd | Professional & scientific | 2004 |
| Digicube Limited | Information & communication | 2008 |
| Digimised Limited | Other services | 2026 |
| Digital Armour (International) Limited | Information & communication | 2023 |
| Digital Armour Ltd | Administrative & support | 2017 |
| Directional Drilling Design & Management Ltd | Professional & scientific | 2013 |
| Dirty Bear Ltd | Water & waste | 2025 |
| DLR Online Ltd | Wholesale & retail | 2026 |
| DM Thomas ENT Services Limited | Health & social care | 2011 |
| Dodge Designs Ltd | Arts & recreation | 2023 |
| Donald Humberstone & Company Limited | Real estate | 1947 |
| Douglas Electronic Industries Limited | Manufacturing | 1946 |
| Dragonville Cars Ltd | Wholesale & retail | 2014 |
| Dream Destination Travels UK Limited | Wholesale & retail | 2025 |
| Drplamen Care Ltd | Health & social care | 2013 |
| Dunn Clayton Holdings Ltd | Information & communication | 2025 |
| E and T Consultancy Limited | Education | 2024 |
| Easifence UK Ltd | Manufacturing | 2024 |
| East Anglia Holdings Limited | Construction | 1964 |
| East Coast Carpets (Lincs) Limited | Wholesale & retail | 2006 |
| East Coast Commercial Limited | Wholesale & retail | 2013 |
| East Coast Flooring Holdings Limited | Financial services | 2021 |
| East Coast Padel Cleethorpes Limited | Arts & recreation | 2026 |
| East Gate Haircut Ltd | Other services | 2025 |
| East Lincs Recycling Solutions Limited | Water & waste | 2010 |
| East Lindsey Information Technology Centre | Education | 1984 |
| East Mids Limited | Administrative & support | 2012 |
| East River Insight Company Limited | Professional & scientific | 2013 |
| Eastfield Road Holdings Ltd | Construction | 2020 |
| Eastgate Developments Limited | Construction | 2017 |
| Eastgate OIL & GAS Limited | Professional & scientific | 2013 |
| Eastside Developments Lincs Ltd | Construction | 2019 |
| Eco Green Manure Limited | Water & waste | 2023 |
| ED Stubbs Next Generation Investments Ltd | Financial services | 2024 |
| Edge Surveying Ltd | Professional & scientific | 2020 |
| Einreb Ltd | Manufacturing | 2002 |
| EJ Building & Groundworks Ltd | Construction | 2019 |
| Elinx Physiotherapy Limited | Other services | 2016 |
| Elisabeth Ortigia Limited | Other services | 2011 |
| Elysium Beauty Salon Limited | Extraterritorial | 2003 |
| EMA Louth Ltd | Wholesale & retail | 2025 |
| EN Engineering Ltd | Manufacturing | 2025 |
| Encore Shipping Limited | Transport & logistics | 1992 |
| English Wine Producers Limited | Other services | 2000 |
| Entertaining Activities (Lincs) Ltd | Other services | 2016 |
| Equable Legal Compliance and Investigations Limited | Professional & scientific | 2023 |
| Erik Pelham Limited | Extraterritorial | 2019 |
| ERJ Holdings Limited | Professional & scientific | 2021 |
| ERJ Investments Limited | Professional & scientific | 2010 |
| Eskar Strategic Limited | Professional & scientific | 2021 |
| ESL Assets Ltd | Financial services | 2024 |
| Essentiago Ltd | Wholesale & retail | 2025 |
| Estuary Media Group Ltd | Information & communication | 2018 |
| ETC Stores Limited | Wholesale & retail | 2005 |
| Etfrix Ltd | Real estate | 2021 |
| Europa Industries Limited | Manufacturing | 1987 |
| Evandths Financial Ltd | Financial services | 2017 |
| EVE & Ranshaw Limited | Real estate | 1950 |
| Evebrook Properties Limited | Real estate | 2021 |
| Eventum Ltd | Professional & scientific | 2026 |
| Everyday Essential Products Ltd | Wholesale & retail | 2021 |
| Ewing Plumbing Limited | Construction | 2005 |
| Extraordinary Travel Company Limited | Administrative & support | 2025 |
| Faber Architecture Ltd | Professional & scientific | 2017 |
| Fabriform Engineering Limited | Manufacturing | 2002 |
| Fabulous Gifts Ltd | Wholesale & retail | 2021 |
| FAC2ORY Limited | Administrative & support | 2019 |
| Fairbairn Telecom Ltd | Information & communication | 2017 |
| Fairfax Industries Limited | Professional & scientific | 2020 |
| Fairway Autos Limited | Wholesale & retail | 2021 |
| Faithful Hound Media Limited | Information & communication | 2023 |