| Dorasuk Ltd | Manufacturing | 2024 |
| Dotwall Web Design Ltd | Professional & scientific | 2020 |
| Double a Automotives Limited | Wholesale & retail | 2015 |
| Double Glazing Supplies (Glasgow) Limited | Wholesale & retail | 1985 |
| Double Glazing Supplies (Leeds) Limited | Wholesale & retail | 1984 |
| Double Glazing Supplies (Northern Ireland) Limited | Wholesale & retail | 1988 |
| Double Glazing Supplies (South West) Limited | Wholesale & retail | 1987 |
| Double Glazing Supplies (Southern) Limited | Wholesale & retail | 1981 |
| Dough City Ltd | Wholesale & retail | 2025 |
| Doughcrust Ltd | Manufacturing | 2021 |
| Doughty Sports Pubs Ltd | Hospitality | 2025 |
| Dowding Solicitors Limited | Professional & scientific | 2019 |
| Dozen Oranges Limited | Real estate | 2018 |
| DR Mazid Ltd | Health & social care | 2023 |
| DR Michael Nandakumar & DR Shamina Tayub Ltd | Health & social care | 2018 |
| DR Michelle Ltd | Health & social care | 2025 |
| DR NRQ Limited | Health & social care | 2024 |
| DR Prasad Limited | Health & social care | 2019 |
| DR R J Robinson Ltd | Health & social care | 2016 |
| DR Simon Ltd | Health & social care | 2025 |
| DR YOU Ltd | Health & social care | 2018 |
| Drainclear (Leicester) Limited | Administrative & support | 1999 |
| Draw Construction Limited | Construction | 1998 |
| DRB Recovery and Transport Ltd | Transport & logistics | 2023 |
| Dream Coat Restorations Limited | Construction | 2019 |
| Dreamfrog Media Ltd | Information & communication | 2016 |
| Dresses 2 Impress U Ltd | Wholesale & retail | 2011 |
| DRIVE4IT Limited | Transport & logistics | 2023 |
| DRJ Crew Limited | Other services | 2018 |
| DRJ Recruitment Ltd | Administrative & support | 2015 |
| DRM Asset Management Limited | Real estate | 2021 |
| Drop-Off Services Ltd | Transport & logistics | 2024 |
| Drug Discovery Solutions Limited | Professional & scientific | 2022 |
| Drugs Audit Limited | Information & communication | 2021 |
| Drury and Drury Limited | Health & social care | 2017 |
| DS Trade Motors Limited | Wholesale & retail | 2023 |
| Dscm Limited | Professional & scientific | 2006 |
| DSD Loughborough Ltd | Hospitality | 2023 |
| DSE Consulting Limited | Extraterritorial | 2007 |
| DSR (Loughborough) Limited | Financial services | 2016 |
| DSW IT Services Limited | Information & communication | 2007 |
| DSY Management Services Ltd | Professional & scientific | 2025 |
| DTA Consulting Services Limited | Professional & scientific | 2017 |
| Dual Plumbing Heating Ltd | Construction | 2026 |
| Duckworth Property Group Limited | Real estate | 2023 |
| Ducky Ltd | Wholesale & retail | 2022 |
| Dueltitan Limited | Real estate | 2003 |
| Dulverton Properties Ltd | Real estate | 2016 |
| Dumpling Hood Lough Limited | Hospitality | 2026 |
| Dumtu Ltd | Wholesale & retail | 2025 |
| Dunning Property Group Ltd | Real estate | 2026 |
| Dusk Nails & Beauty Ltd | Other services | 2024 |
| Dust Parts Limited | Water & waste | 2023 |
| Dutysheet Limited | Professional & scientific | 2006 |
| DW Kitchens and Interiors Ltd | Construction | 2021 |
| DWG Infraco Limited | Construction | 2010 |
| DWG Investments Limited | Real estate | 2025 |
| DWG Plans East Midlands Limited | Professional & scientific | 2025 |
| DWG Timber Components Limited | Professional & scientific | 2016 |
| Dw’S Motor Service’S Limited | Wholesale & retail | 2024 |
| DX Logistics Ltd | Transport & logistics | 2023 |
| Dynamech Technical Services Ltd | Construction | 2023 |
| Dynamic INT Ltd | Administrative & support | 2016 |
| Dynamite Construction Limited | Construction | 2025 |
| Dynemonics Limited | Professional & scientific | 2008 |
| E & W Langley Limited | Hospitality | 2021 |
| E a Financial Services Ltd | Professional & scientific | 2026 |
| E C Executive Search Limited | Administrative & support | 2003 |
| E James Consultancy Limited | Education | 2013 |
| E Lockwood Ltd | Professional & scientific | 2022 |
| E Mewies Consulting Ltd | Professional & scientific | 2023 |
| E S P Services Loughborough Ltd | Administrative & support | 2021 |
| E Vohra Limited | Wholesale & retail | 2016 |
| E W Healthcare Services Ltd | Health & social care | 2019 |
| E&G Drylining Ltd | Construction | 2021 |
| E-Cargo Vehicles Limited | Wholesale & retail | 2019 |
| E-Power Solutions Ltd | Wholesale & retail | 2026 |
| E.W.C Limited | Construction | 2022 |
| E3 Performance Partnership Ltd | Administrative & support | 2009 |
| Eaglets Haven Childcare Ltd | Health & social care | 2026 |
| Earcare Plus Ltd | Wholesale & retail | 2026 |
| Earwego&Co Limited | Health & social care | 2025 |
| East Goscote Fish Bar Limited | Hospitality | 2024 |
| East Leake Funeral Service Limited | Other services | 2018 |
| East Midlands Access Limited | Administrative & support | 2018 |
| East Midlands Construction & Development Limited | Construction | 2015 |
| East Midlands Driver Training Limited | Education | 2018 |
| East Midlands Drum Tuition Ltd | Education | 2026 |
| East Midlands Electrical Contractors Limited | Construction | 2004 |
| East Midlands Forklifts Limited | Professional & scientific | 2008 |
| East Midlands Property Management Limited | Real estate | 2003 |
| East Midlands Service Centre Ltd | Wholesale & retail | 2012 |
| East Midlands Site Engineers Ltd | Administrative & support | 2014 |
| East Midlands Transport Ltd | Transport & logistics | 2021 |
| East West Link (UK) Limited | Administrative & support | 2009 |
| East, Harris & Burton Properties Limited | Real estate | 2017 |
| Eastco Construction Limited | Extraterritorial | 2016 |
| Eastco Developments Limited | Construction | 2003 |
| Eastco Homes Ltd | Construction | 2016 |
| Eastern Spice Restaurant Ltd | Hospitality | 2025 |