| Darwin Topco Limited | Professional & scientific | 2016 |
| Daryl Lucy Properties Ltd | Real estate | 2021 |
| Daryll Neita Athletics Community Limited | Education | 2024 |
| Dasbro Limited | Professional & scientific | 1993 |
| Dash Brews Limited | Hospitality | 2024 |
| Dash Cars Limited | Wholesale & retail | 2003 |
| Dashkeep Limited | Information & communication | 2025 |
| Data One Limited | Information & communication | 1992 |
| Datalink Design Limited | Extraterritorial | 2005 |
| Datamove Cloud Limited | Information & communication | 2013 |
| Datavaluepeople LLP | | 2020 |
| Datex Fabrics Limited | Professional & scientific | 1987 |
| Datum Engineering & Consultancy Ltd | Professional & scientific | 2024 |
| Dave Abbott Audio Limited | Manufacturing | 2024 |
| Dave Beresford Ltd | Professional & scientific | 2016 |
| Dave Mann Music Limited | Wholesale & retail | 2014 |
| Dave Watson Film Ltd | Extraterritorial | 2024 |
| David Grace Estate Agents Limited | Real estate | 2025 |
| David J Barker Ltd | Agriculture & fishing | 2003 |
| David J Barnett Limited | Professional & scientific | 2002 |
| David Lancaster Software Limited | Information & communication | 2024 |
| David Lowe Garage Services Limited | Wholesale & retail | 2003 |
| David Pycroft Architectural Services Limited | Other services | 2007 |
| David Ross Education Services Ltd | Education | 2014 |
| David Stanley Commercials Limited | Real estate | 1983 |
| David Stanley Sales Limited | Wholesale & retail | 1981 |
| David Sturgis Limited | Real estate | 2018 |
| David, Thomas & Waring Ltd | Financial services | 2018 |
| Davie Developments Ltd | Real estate | 2024 |
| Davies & Stevens Automobile Engineers Limited | Wholesale & retail | 2008 |
| Davis Westbridge Limited | Construction | 1995 |
| Davis(Forest Field)Limited | Professional & scientific | 1949 |
| Davy Designs Limited | Professional & scientific | 2007 |
| Dawes Capital Limited | Information & communication | 2019 |
| Day Van Conversions Ltd | Manufacturing | 2023 |
| Day,Son & Hewitt | Wholesale & retail | 1995 |
| Daziya Limited | Wholesale & retail | 2007 |
| Dazzlers Cleaning Services Limited | Administrative & support | 2019 |
| DB Acoustic Products Ltd | Other services | 2022 |
| DB Safety Training Ltd | Professional & scientific | 2026 |
| Dbcerigo Ltd | Information & communication | 2017 |
| DBL Echo Limited | Health & social care | 2022 |
| DC Loughborough Limited | Hospitality | 2026 |
| DCI (Kitchens) Ltd | Construction | 2003 |
| DCR Assets Ltd | Real estate | 2024 |
| DCR Financial Services Ltd | Financial services | 2023 |
| Dcro Properties Limited | Real estate | 2018 |
| Dcrt | Other services | 2017 |
| DD Associates Limited | Professional & scientific | 2005 |
| DD Inc Ltd | Wholesale & retail | 2024 |
| DE Duve Drinks Limited | Wholesale & retail | 2018 |
| DE Grill Ltd | Hospitality | 2020 |
| DE Luxe Short Stays Ltd | Hospitality | 2019 |
| DE Novo Auto Ltd | Wholesale & retail | 2023 |
| DE Rijk & Sons Limited | Professional & scientific | 1984 |
| DE Rijk Limited | Wholesale & retail | 1977 |
| De-La-Rue Consultancy Ltd | Professional & scientific | 2024 |
| Dead on the Vine Limited | Extraterritorial | 2020 |
| Dead Profit Clothing Company Limited | Wholesale & retail | 2012 |
| Deadlock Limited | Real estate | 1998 |
| Deal Dome Ltd | Wholesale & retail | 2025 |
| Dealflow Property Sourcing Ltd | Administrative & support | 2026 |
| Dean Burbidge Ltd | Construction | 2012 |
| Deane Solutions Ltd | Professional & scientific | 2020 |
| Debtco One Limited | Financial services | 2002 |
| Deca Beams Ltd | Manufacturing | 2024 |
| Decem Projects Limited | Construction | 2022 |
| Decipher Consultancy Limited | Information & communication | 2015 |
| Decision LAB Ltd | Professional & scientific | 2011 |
| Decision Maker Services Ltd | Professional & scientific | 2008 |
| Decklin's Domain Ltd | Information & communication | 2025 |
| Decoded Limited | Education | 2011 |
| Decon Consultancy Services Ltd | Professional & scientific | 2021 |
| Decorum Projects Ltd | Construction | 2019 |
| Decotel Group Limited | Professional & scientific | 1980 |
| Decotel Limited | Wholesale & retail | 1946 |
| Deep Veer Ltd | Real estate | 2023 |
| Deer Orchard Retreats Limited | Other services | 2020 |
| Deeserve Limited | Information & communication | 2007 |
| Defacto Searches Limited | Professional & scientific | 2016 |
| Defend Animals Ltd | Information & communication | 2022 |
| Degvisa Investments Limited | Real estate | 2025 |
| Deliveraki Ltd | Hospitality | 2019 |
| Dell Leisure Limited | Professional & scientific | 2016 |
| Delphinus TMC Limited | Professional & scientific | 2010 |
| Delta Coaching Limited | Education | 2015 |
| Delta Power Commissioning Limited | Other services | 2008 |
| Delta Technical Consulting Limited | Information & communication | 2010 |
| Demand Excellence Ltd | Health & social care | 2024 |
| Demelo Wine Services Ltd | Wholesale & retail | 2024 |
| Den's Plumbing & Heating Ltd | Construction | 2024 |
| Denali Properties Limited | Real estate | 2017 |
| Denmark Ward Limited | Other services | 2018 |
| Dental Devices and Supplies Limited | Manufacturing | 2003 |
| Dental Xlnc Laboratory Ltd | Health & social care | 2022 |
| Derby Road Convenience Store Ltd | Wholesale & retail | 2025 |
| Derby Road General Store Ltd | Wholesale & retail | 2020 |
| Dermiology Aesthetics Clinic Ltd | Health & social care | 2023 |
| Derms Development Limited | Manufacturing | 2004 |
| Design for People Limited | Information & communication | 2013 |