| Enfys Windows & Roofs Ltd | Construction | 2009 |
| ENG Automation and Controls Ltd | Manufacturing | 2019 |
| Entwined by Sarah Ltd | Manufacturing | 2026 |
| Enviresource Consulting Ltd. | Water & waste | 2011 |
| Envirotreat (Wales) Ltd | Administrative & support | 2010 |
| Envph Ltd | Health & social care | 2023 |
| Equi-Swim Therapy Ltd | Professional & scientific | 2024 |
| Equinox Physiotherapy Partnership Limited | Arts & recreation | 2011 |
| Equitable Financial Solutions Limited | Administrative & support | 2019 |
| Erbdmpk Ltd | Professional & scientific | 2022 |
| ERW Developments Limited | Wholesale & retail | 2002 |
| Estuary Properties Limited | Real estate | 2000 |
| Etto's Coffee Shop Limited | Hospitality | 2017 |
| Euro Kubus Ltd | Wholesale & retail | 2025 |
| Euro Market SW Ltd | Wholesale & retail | 2024 |
| European Telecom Solutions Limited | Real estate | 2017 |
| EV Marine Ltd | Professional & scientific | 2019 |
| EV Recycling Ltd | Water & waste | 2019 |
| Evacore Solutions Ltd | Professional & scientific | 2025 |
| Evans & Sons Recovery and Transportation Ltd | Transport & logistics | 2020 |
| Evans Aviation Consultancy Limited | Manufacturing | 2023 |
| Evans Lush Lawns Ltd | Administrative & support | 2025 |
| Evertrust Maintenance Solutions Limited | Administrative & support | 2025 |
| Everything Motors Limited | Wholesale & retail | 2016 |
| EVS Motors Ltd | Wholesale & retail | 2017 |
| EWM Financial Consultancy Ltd | Financial services | 2014 |
| EX Stasis Games Ltd | Manufacturing | 2017 |
| EX Stock Steels Limited | Wholesale & retail | 2001 |
| EX1 - Digital Forensic Services Ltd | Information & communication | 2019 |
| Excel (Steel Stock) Limited | Wholesale & retail | 1978 |
| Excel Precision Engineering Services Limited | Professional & scientific | 1994 |
| Exhale 1 Vape Ltd | Wholesale & retail | 2025 |
| Exhale Llanelli Vape Ltd | Wholesale & retail | 2025 |
| Exodac Ltd | Wholesale & retail | 2025 |
| Expa Limited | Construction | 2004 |
| Exquisite by Design Ltd | Professional & scientific | 2013 |
| Extend Planning Ltd | Professional & scientific | 2026 |
| Fabcity Global Ltd | Wholesale & retail | 2025 |
| FACILIT8 Business Support Ltd | Administrative & support | 2018 |
| FACILIT8 Systems Ltd | Administrative & support | 2025 |
| Fairway Coastal Holdings Limited | Hospitality | 2026 |
| Falconer Removals Limited | Transport & logistics | 2015 |
| Farmtricity Ltd | Construction | 2012 |
| Felden Engineering Limited | Professional & scientific | 2020 |
| Felin Geri Activity Centre Limited | Extraterritorial | 2012 |
| Felinfoel Business Hub Limited | Real estate | 2024 |
| Felinfoel Executive Committee Ltd | Other services | 2011 |
| Felinfoel RFC Ltd | Arts & recreation | 2023 |
| Fellowship of Animal Behaviour Clinicians CIC | Other services | 2020 |
| Ferenstone Optometry Limited | Health & social care | 2022 |
| Ffenestri Cleaning Services Ltd | Administrative & support | 2024 |
| Fflêr Limited | Construction | 2017 |
| Ffordd Werdd Management Gorslas Ltd | Real estate | 2018 |
| Ffynnon Carreg Limited | Manufacturing | 2012 |
| Fibrelux Ltd | Wholesale & retail | 2026 |
| Fiction Factory Limited | Information & communication | 2002 |
| Field & Forest Game Limited | Wholesale & retail | 2026 |
| Field 2 Fork Cutting Services Ltd | Manufacturing | 2023 |
| Fight Project BJJ C.I.C. | Arts & recreation | 2025 |
| Final Coat Ltd | Construction | 2018 |
| Finishing Touches Cleaning Ltd | Other services | 2014 |
| Finishing Touches Developments Ltd | Real estate | 2018 |
| Finishing Touches Enterprises Ltd | Financial services | 2026 |
| Finishing Touches Properties Ltd | Real estate | 2024 |
| Finishing Touches Rentals Ltd | Hospitality | 2022 |
| Fire Safety (West Wales) Ltd | Administrative & support | 2015 |
| Firecracker Films I Ltd | Information & communication | 2022 |
| Firecracker Films Limited | Information & communication | 2002 |
| First CMS Limited | Information & communication | 2003 |
| First of March Limited | Wholesale & retail | 2019 |
| Fischetti Services Limited | Information & communication | 2008 |
| Fishgen Limited | Agriculture & fishing | 1996 |
| Fitter Body Ladies Llanelli Limited | Arts & recreation | 2019 |
| FJL Tanning Ltd | Administrative & support | 2025 |
| Flavaz ENT Ltd | Hospitality | 2025 |
| Flear Marketing Ltd | Professional & scientific | 2018 |
| Flip Development Limited | Real estate | 2018 |
| Flooring the Competition Limited | Construction | 2009 |
| Floxiam Ltd | Professional & scientific | 2025 |
| Focus Strategy Limited | Professional & scientific | 2020 |
| Foodables Ltd | Wholesale & retail | 2023 |
| Football FUN Factory (Community 049) Limited | Arts & recreation | 2022 |
| Foothold Cymru | Education | 1991 |
| Foothold Limited | Professional & scientific | 2018 |
| Ford Property Management Ltd | Construction | 2020 |
| Forge Brewing Company Ltd | Manufacturing | 2025 |
| Foster Communications Limited | Wholesale & retail | 2000 |
| Foster Electrical Limited | Information & communication | 2020 |
| Four Elements Learning & Development Ltd | Other services | 2023 |
| Four Roads Property Ltd | Real estate | 2021 |
| Fourtwentees Ltd | Wholesale & retail | 2020 |
| FR13 Properties Group Ltd | Households | 2026 |
| Francis Lettings & Management Limited | Households | 2025 |
| Frankie’S Eyewear Ltd | Wholesale & retail | 2024 |
| Fratley Consulting Limited | Information & communication | 2019 |
| Freds Garage Limited | Wholesale & retail | 2013 |
| Freedom From Tedium Limited | Administrative & support | 2018 |
| Fresh Food Packaging Limited | Wholesale & retail | 2024 |
| Frinje Ltd. | Manufacturing | 2016 |
| Frosty Electrical Ltd | Construction | 2020 |