| DA Houses Limited | Real estate | 2026 |
| DA Venezia Limited | Hospitality | 2022 |
| Dacnet Limited | Financial services | 2014 |
| DAE Tech Ltd | Information & communication | 2020 |
| Dagobah Industries Limited | Health & social care | 2017 |
| Dainex Limited | Transport & logistics | 2017 |
| Daizies Publishing Ltd | Information & communication | 2021 |
| Dalex Holdings Ltd | Real estate | 2026 |
| Danalise Properties Limited | Real estate | 2019 |
| Darcey's Interiors Ltd | Wholesale & retail | 2022 |
| Darius&Iva Ltd | Transport & logistics | 2016 |
| Darlings Property Ltd | Households | 2025 |
| David Brunt & Associates Limited | Professional & scientific | 2007 |
| David Jones (Solicitors) Limited | Professional & scientific | 2008 |
| Davwen Limited | Wholesale & retail | 2006 |
| Dawsons Legal Services Limited | Professional & scientific | 2015 |
| DC Autos Llandudno Ltd | Wholesale & retail | 2025 |
| DCA HV Services Ltd | Construction | 2024 |
| Ddraig Goch Developments Ltd | Real estate | 2019 |
| Dealmeout CIC | Other services | 2020 |
| Designed Housing Solutions CYF | Hospitality | 2025 |
| DHI Group Limited | Financial services | 2023 |
| Dialeat Ltd | Information & communication | 2023 |
| Diamond Weightlifting Ltd | Arts & recreation | 2025 |
| Digitally Focused Limited | Professional & scientific | 2017 |
| Direct Developments & Construction Ltd | Construction | 2024 |
| Direct Price Ltd | Wholesale & retail | 2024 |
| Diretgoods Ltd | Wholesale & retail | 2025 |
| DJI Properties Limited | Real estate | 2020 |
| Djsjt Solutions Ltd | Professional & scientific | 2021 |
| DK Barbers Shop Ltd | Other services | 2023 |
| DLH Property Solutions & Maintenance NW Ltd | Construction | 2022 |
| Doctor UZ Medical Ltd | Health & social care | 2021 |
| Dollop! Ice Cream Parlour Ltd | Wholesale & retail | 2022 |
| Dotona Ltd | Professional & scientific | 2023 |
| DPA Properties Ltd | Construction | 2015 |
| Dpggriff Ltd | Hospitality | 2026 |
| DR S Nagaraj Limited | Health & social care | 2012 |
| DR Stacey Hunter Behaviour Consultancy Ltd | Education | 2024 |
| Dragonden Properties Ltd | Real estate | 2023 |
| Draig Interactive Ltd | Information & communication | 2025 |
| Drapers Carpets Ltd | Administrative & support | 2016 |
| Drapers Contracts Ltd | Wholesale & retail | 2018 |
| DRB Plastering & Joinery Ltd | Construction | 2022 |
| Driveway Specialist Ltd | Professional & scientific | 2025 |
| Drjali Limited | Health & social care | 2024 |
| Drjsm Limited | Health & social care | 2022 |
| Dudley and George's Limited | Wholesale & retail | 2022 |
| Dudley's Kitchen Limited | Hospitality | 2025 |
| Dunoon Hotels Limited | Hospitality | 2002 |
| Duty to Create Ltd | Extraterritorial | 2014 |
| E & C Property Management Limited | Households | 2018 |
| E & H Griffith Ltd | Construction | 2024 |
| E-Geo Solutions Limited | Professional & scientific | 2005 |
| Eagle EYE Cellular Pathology Diagnostics Limited | Extraterritorial | 2015 |
| East Restaurant (Gwynedd) Limited | Hospitality | 2016 |
| Easy Shop @ Ltd | Wholesale & retail | 2024 |
| Ecdjb Limited | Administrative & support | 2017 |
| Ecospark Energy Ltd | Manufacturing | 2025 |
| Eddisbury Homes Ltd | Real estate | 2018 |
| Edwards-Hughes Limited | Other services | 2016 |
| EGM Consulting Limited | Mining & quarrying | 2026 |
| Eira Engineering Ltd | Information & communication | 2015 |
| Eira Project Ltd | Administrative & support | 2024 |
| Electroquest (UK) Limited | Wholesale & retail | 2013 |
| Elevate Your Sole Ltd | Wholesale & retail | 2013 |
| Elite Travel Llandudno Ltd | Transport & logistics | 2026 |
| Elixir Agency Ltd | Professional & scientific | 2017 |
| Ellsdiani Limited | Wholesale & retail | 2023 |
| Elphick Studios Limited | Arts & recreation | 2024 |
| Elysium Chocolates Limited | Manufacturing | 2019 |
| EM Wind Ltd | Administrative & support | 2018 |
| Emerge Recruiting Ltd | Administrative & support | 2003 |
| Emperor KAI Ltd | Hospitality | 2020 |
| Empire Hotel (Llandudno) Limited | Hospitality | 1947 |
| Empire Hotel Holdings Limited | Hospitality | 2015 |
| Enfys Estates Ltd | Real estate | 2021 |
| Enlightened ERP Limited | Information & communication | 2017 |
| Enlli Medical Limited | Health & social care | 2024 |
| ENT Surgical Limited | Health & social care | 2026 |
| Enviro Wind (NW) Ltd | Manufacturing | 2025 |
| Enviro-Wind Limited | Manufacturing | 2015 |
| Equine Podiatry Training Ltd | Professional & scientific | 2008 |
| Esedra LR Limited | Professional & scientific | 2012 |
| Esposito Hospitality Limited | Hospitality | 2017 |
| European Mini Marke Limited | Wholesale & retail | 2026 |
| EV8 Consulting Limited | Professional & scientific | 2020 |
| Event Cooks Ltd | Hospitality | 2025 |
| Event Data Technologies Limited | Administrative & support | 2023 |
| Everything North Wales Limited | Information & communication | 2014 |
| Excalibur Petroleum Limited | Mining & quarrying | 2012 |
| Extraordinaryness Ltd | Administrative & support | 2025 |
| Exvanta Ltd | Other services | 2022 |
| Eyas Properties Ltd | Real estate | 2026 |
| Faenol Garage Limited | Wholesale & retail | 2004 |
| Fairways (North Wales) Limited | Real estate | 2023 |
| Family Mediation North West Ltd | Professional & scientific | 2025 |
| Fastlane Parcels Ltd | Transport & logistics | 2026 |
| FD Paint Services Limited | Construction | 2012 |
| Ffarm Vintners Limited | Wholesale & retail | 2011 |