| Show NO Mercy Ltd | Wholesale & retail | 2026 |
| Show-Dex Ltd | Wholesale & retail | 2021 |
| Showbiz Products Collective Ltd | Manufacturing | 2025 |
| Showrate Limited | Administrative & support | 2026 |
| Showroom Slumber Ltd | Wholesale & retail | 2025 |
| Showtime Entertainment & Event Management Limited | Other services | 2009 |
| SHP Ashford Limited | Financial services | 2021 |
| SHP Bancroft Ltd | Real estate | 2018 |
| SHP Brockwell Ltd | Real estate | 2021 |
| SHP Hire & Sales Ltd | Manufacturing | 2025 |
| SHP Livingstone Ltd | Real estate | 2019 |
| SHP Wavertree Ltd | Real estate | 2021 |
| SHP Wellington Ltd | Real estate | 2021 |
| SHP2 Ltd | Information & communication | 2019 |
| SHPROP1 Ltd | Information & communication | 2024 |
| Shredfast Programme Ltd | Health & social care | 2020 |
| Shredfast Vocational Training Ltd | Education | 2025 |
| Shreejii Ltd | Hospitality | 2025 |
| Shrewsbury Properties Ltd | Professional & scientific | 2015 |
| Shri Drinks Ltd | Hospitality | 2025 |
| Shri Kula Vidyalaya Ltd | Education | 2026 |
| Shrimp Products Ltd | Wholesale & retail | 2021 |
| Shua Limited | Arts & recreation | 2015 |
| Shua Online Ltd | Information & communication | 2020 |
| Shua Properties Ltd | Real estate | 2021 |
| Shubox Ltd | Wholesale & retail | 2008 |
| Shubyatri Foods Ltd | Hospitality | 2025 |
| Shubyatri Imports Ltd | Other services | 2025 |
| Shubyatri Media Ltd | Professional & scientific | 2025 |
| Shucos Ltd | Hospitality | 2016 |
| Shudehill Hotel Company Limited | Hospitality | 2005 |
| Shuffleding Limited | Wholesale & retail | 2022 |
| Shuga Shuga Liverpool Ltd | Hospitality | 2022 |
| Shukjai Thai Massage Limited | Health & social care | 2025 |
| Shun Feng Express Limited | Wholesale & retail | 2019 |
| Shunfa 168 Ltd | Hospitality | 2026 |
| Shut OUT the Light Films Ltd | Information & communication | 2020 |
| Shuteye Ltd | Hospitality | 2026 |
| Shutterblades Limited | Professional & scientific | 2022 |
| Shuttleworth Consultancy Limited | Financial services | 2011 |
| Shuyuan Limited | Hospitality | 2024 |
| SI LA Parella Limited | Hospitality | 2017 |
| Si's General Store Ltd | Wholesale & retail | 2023 |
| Siae Microelettronica Limited | Information & communication | 1995 |
| Siam Assetco Ltd | Professional & scientific | 2020 |
| SIB Associates Ltd | Professional & scientific | 2009 |
| Sibidi Ltd | Information & communication | 2024 |
| Sibsey Lifestyle Ltd | Construction | 2014 |
| Sibsmart Mortgages Ltd | Financial services | 2026 |
| Sicilian Concept Limited | Hospitality | 2026 |
| Sidarlo Limited | Construction | 2020 |
| Siddhi Properties Limited | Real estate | 2017 |
| Siddiki Liverpool Ltd | Hospitality | 2024 |
| Sidekickers CIC | Arts & recreation | 2024 |
| Sidemersey Livings Limited | Real estate | 2023 |
| Sidequest Enterprises Ltd | Information & communication | 2026 |
| Sidlighting Ltd | Other services | 2009 |
| Sidney George Products Ltd | Wholesale & retail | 2024 |
| Sidney H. Hooper & Company Limited | Financial services | 1995 |
| Sidney&Co Limited | Real estate | 2014 |
| Sidor Logistics Limited | Transport & logistics | 2014 |
| Sidra Liverpool Ltd | Real estate | 2023 |
| Siechan Events Ltd | Administrative & support | 2024 |
| Siedleccy Properties Ltd | Real estate | 2025 |
| Sieltza Limited | Professional & scientific | 2018 |
| Sienna Gelling Limited | Administrative & support | 2025 |
| Sienna Mound Limited | Real estate | 2003 |
| SIERA45 Ltd | Wholesale & retail | 2023 |
| Sierra Blinds Limited | Manufacturing | 2003 |
| Siform Ltd | Information & communication | 2023 |
| Sight and Mind CIC | Education | 2016 |
| Sighthill Limited | Real estate | 2006 |
| Sigma Critical Insights Limited | Professional & scientific | 2023 |
| Sigma Educational Consultancy Ltd | Education | 2014 |
| Sigma Homes NW Limited | Construction | 2025 |
| Sigma Property Services Limited | Real estate | 2017 |
| Sign 2K Limited | Construction | 2006 |
| Sign Centre (North West) Limited | Manufacturing | 2010 |
| Sign Clarity Ltd | Professional & scientific | 2026 |
| Sign Loft Ltd | Manufacturing | 2025 |
| Signal and Shape Ltd | Professional & scientific | 2026 |
| Signal Music Tuition Ltd | Education | 2022 |
| Signature (APH) Ltd | Construction | 2017 |
| Signature Apartments Bold Street Limited | Hospitality | 2016 |
| Signature Apartments Matthew Street Limited | Hospitality | 2016 |
| Signature Bespoke Barber Ltd | Other services | 2024 |
| Signature Bespoke Holdings Ltd | Wholesale & retail | 2020 |
| Signature Bespoke Limited | Manufacturing | 2019 |
| Signature Bespoke London Limited | Wholesale & retail | 2023 |
| Signature Campus Limited | Hospitality | 2015 |
| Signature Cards & Gifts Limited | Administrative & support | 2004 |
| Signature City Ltd | Administrative & support | 2025 |
| Signature Community Events Community Interest Company | Education | 2026 |
| Signature Futures Limited | Health & social care | 2025 |
| Signature Home Improvements (North West) Ltd | Construction | 2019 |
| Signature Homes North West Limited | Health & social care | 2025 |
| Signature LED Lighting Ltd | Wholesale & retail | 2017 |
| Signature Living Arthouse Square Limited | Hospitality | 2015 |
| Signature Property Group Ltd | Real estate | 2019 |
| Signature Shankly Apartments Limited | Hospitality | 2016 |