| Santuary Cleaning Limited | Transport & logistics | 2025 |
| Saoo Medical Limited | Health & social care | 2025 |
| Saot Limited | Professional & scientific | 2024 |
| Saoud Constructions Ltd | Construction | 2024 |
| SAP Clothing Ltd | Wholesale & retail | 2025 |
| SAP Joinery (NW) Limited | Construction | 2025 |
| SAP Joinery Limited | Construction | 2014 |
| SAP Project Solutions Ltd | Construction | 2023 |
| SAP Projects NW Limited | Construction | 2025 |
| Saphire Electrical Services Limited | Construction | 2002 |
| Sapien 2.0 Limited | Health & social care | 2016 |
| Sapira Media Ltd | Information & communication | 2026 |
| Sapphire Aesthetics and Body Contouring Ltd | Other services | 2024 |
| Sapphire Design Ltd | Professional & scientific | 2022 |
| Sapphire Futures Ltd | Health & social care | 2024 |
| Sapphire Properties Liverpool Limited | Real estate | 2024 |
| Sapphire Stays Ltd | Real estate | 2019 |
| Sapphire Way Consulting Ltd | Information & communication | 2024 |
| Sapphirina Limited | Wholesale & retail | 2015 |
| Sapporo Teppanyaki (Manchester) Limited | Hospitality | 2004 |
| Sapporo Teppanyaki Limited | Hospitality | 2003 |
| Sapre Medicolegal Ltd | Health & social care | 2024 |
| Sara Arora Skin Consultant Ltd | Other services | 2022 |
| Sara Leigh Properties Ltd | Real estate | 1978 |
| Sarah Denise Studio Ltd | Professional & scientific | 2019 |
| Sarah Farrelly Spmu Ltd | Other services | 2025 |
| Sarah KAY Vinyls Ltd | Wholesale & retail | 2017 |
| Sarah Louise Properties Ltd | Real estate | 2025 |
| Sarah Mcbride Consultancy Ltd | Professional & scientific | 2019 |
| Sarah Morris Communications Ltd | Professional & scientific | 2024 |
| Sarah Satchell Ltd | Other services | 2014 |
| Sarah Stevenson Inspires Limited | Real estate | 2009 |
| Sarah the VET Ltd | Professional & scientific | 2025 |
| Sarah Welton Ltd | Information & communication | 2022 |
| Sarah White Laser & Aesthetics Limited | Other services | 2015 |
| Sarah White Wellness Limited | Other services | 2018 |
| Sarahayan Ltd | Wholesale & retail | 2023 |
| Sarahlouise Lashes Limited | Wholesale & retail | 2021 |
| Sarahpaedsot Limited | Health & social care | 2025 |
| Saran Management Ltd | Real estate | 2011 |
| Saratov Engineering Ltd | Real estate | 2020 |
| Saray Meat Ltd | Wholesale & retail | 2023 |
| Sarbkar NW Ltd. | Wholesale & retail | 1998 |
| Sarcat Ltd | Hospitality | 2024 |
| Sardam & Hardam Ltd | Other services | 2021 |
| Sarigama Dance Studio Ltd | Arts & recreation | 2022 |
| Sarnaz Holdings Company Ltd | Financial services | 2025 |
| Sarpedon Limited | Professional & scientific | 2017 |
| Sarpolo L6 Ltd | Hospitality | 2025 |
| Sarrah Limited | Transport & logistics | 2016 |
| Sarrush Limited | Wholesale & retail | 2025 |
| Sarto Luxury Tailoring Limited | Wholesale & retail | 2016 |
| Sartuk Ltd | Arts & recreation | 2026 |
| Sarujan Limited | Wholesale & retail | 2023 |
| Sarvin Global Limited | Wholesale & retail | 2026 |
| Sarvin Properties Ltd | Real estate | 2024 |
| Sarwar&Sons Ltd | Wholesale & retail | 2025 |
| SAS (N.W.) Limited | Construction | 2016 |
| SAS (N.W.) Security Services Limited | Administrative & support | 2023 |
| SAS Analytics Ltd | Information & communication | 2015 |
| SAS Lasers Ltd | Other services | 2017 |
| SAS Property Services (Crosby) Ltd | Real estate | 2025 |
| Saspay Ltd | Other services | 2024 |
| Sass Properties J Ltd | Households | 2024 |
| Sasscass Ltd | Hospitality | 2025 |
| Sassy by SBN Limited | Professional & scientific | 2022 |
| Sasu London Limited | Wholesale & retail | 2011 |
| SAT Properties Limited | Other services | 2004 |
| Satar Properties Ltd | Households | 2020 |
| Satchell Moran Solicitors Limited | Professional & scientific | 2015 |
| Satelfy Limited | Information & communication | 2023 |
| Satellite Solutions NW Ltd | Other services | 2011 |
| Satherton Ltd | Wholesale & retail | 2010 |
| Satis Group Limited | Real estate | 2018 |
| Satmor Investments Limited | Real estate | 2013 |
| Satomo Security Services Ltd | Administrative & support | 2024 |
| Satori Property Limited | Real estate | 2017 |
| Satriale's Liverpool Ltd | Hospitality | 2019 |
| Satron Loci Technologies Limited | Information & communication | 2026 |
| Satsstrategy Education Ltd | Information & communication | 2025 |
| Saturio Limited | Information & communication | 2025 |
| Saturn Beauty Ltd | Other services | 2022 |
| Saturn Fire & Security Ltd | Administrative & support | 2021 |
| Saturn Land and Building Limited | Real estate | 2019 |
| Saturn Premier Care Home Limited | Health & social care | 2026 |
| Saturn Premier Care Limited | Health & social care | 2024 |
| Saturn Security Installations Limited | Administrative & support | 1999 |
| Saturn V Properties Ltd | Real estate | 2023 |
| Satyawati Limited | Hospitality | 2018 |
| Sauceinvest Limited | Professional & scientific | 2000 |
| Saunders Associates Limited | Administrative & support | 2001 |
| Saunders Financial Management Limited | Professional & scientific | 2021 |
| Sauternescatering Ltd | Hospitality | 2025 |
| Savage Construction Ltd | Construction | 2018 |
| Savage Dolls Ltd | Wholesale & retail | 2022 |
| Savalan Butchery Ltd | Wholesale & retail | 2025 |
| Savalan Grill Ltd | Hospitality | 2025 |
| Savanna Pool and Snooker Limited | Arts & recreation | 2014 |
| Savannah Heating & Plumbing Ltd | Construction | 2015 |
| Savannah Landscaping Limited | Administrative & support | 2021 |